A5039927863- Mesenchymal stem cell research
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Liver physiology and pathology
- Soybean genetics and cultivation
- Microbial Inactivation Methods
- Immune cells in cancer
- Endoplasmic Reticulum Stress and Disease
- Plant nutrient uptake and metabolism
- Advanced biosensing and bioanalysis techniques
- CRISPR and Genetic Engineering
- Autophagy in Disease and Therapy
- Genetics, Aging, and Longevity in Model Organisms
- Cancer-related molecular mechanisms research
- Fibroblast Growth Factor Research
- Hepatitis C virus research
- Biosensors and Analytical Detection
- Medical Imaging Techniques and Applications
- Microfluidic and Bio-sensing Technologies
- Plant responses to water stress
- Circular RNAs in diseases
- Cardiovascular Disease and Adiposity
- Cancer, Hypoxia, and Metabolism
- Gut microbiota and health
- Respiratory Support and Mechanisms
University of Leeds
2025
Shaoxing University
2024
Second Xiangya Hospital of Central South University
2021-2024
Central South University
2021-2024
Beijing Normal University
2009-2024
Chinese Academy of Sciences
2006-2024
Northwestern Polytechnical University
2021-2024
Henan Polytechnic University
2024
Sichuan University
2024
Beijing Sport University
2021-2024
Abstract The infusion of coronavirus disease 2019 (COVID-19) patients with mesenchymal stem cells (MSCs) potentially improves clinical symptoms, but the underlying mechanism remains unclear. We conducted a randomized, single-blind, placebo-controlled (29 patients/group) phase II trial to validate previous findings and explore potential mechanisms. Patients treated umbilical cord-derived MSCs exhibited shorter hospital stay ( P = 0.0198) less time required for symptoms remission 0.0194) than...
Endoplasmic reticulum (ER) stress activates the adaptive unfolded protein response (UPR) and represents a critical mechanism that underlies metabolic dysfunctions. Fibroblast growth factor 21 (FGF21), hormone is predominantly secreted by liver, exerts broad range of effects upon metabolism carbohydrates lipids. Although increased circulating levels FGF21 have been documented in animal models human subjects with obesity nonalcoholic fatty liver disease, functional interconnections between ER...
Abstract The effects of land‐use changes on the runoff process in midstream plain this arid inland river basin are a key factor rational allocation water resources to middle and lower reaches. question is whether by how much increasingly heavy land use impacts hydrological processes such an basin. catchment Heihe River, one largest rivers region northwest China, was chosen investigate responses change. Flow duration curves were used detect trends variations between upper Relationships among...
Abstract Abnormal aggregation of misfolded pathological proteins in neurons is a prominent feature neurodegenerative disorders including Parkinson’s disease (PD). Perturbations proteostasis at the endoplasmic reticulum (ER) triggers ER stress, activating unfolded protein response (UPR). Chronic stress thought to underlie death during progression, but precise mechanism by which UPR pathways regulate neuronal cell fate remains incompletely understood. Here we report critical role for...
Abstract Non‐alcoholic fatty liver disease ( NAFLD ) is associated with obesity and lifestyle, while exercise beneficial for . Dysregulated micro RNA s (miRs) control the pathogenesis of However, whether could prevent via targeting unknown. In this study, normal or high‐fat diet HF mice were either subjected to a 16‐week running program kept sedentary. Exercise attenuated steatosis in mice. Micro array qRT ‐ PCR demonstrated that miR‐212 was overexpressed liver, reduced by exercise. Next, we...
Abstract Systemic inflammatory processes, including alveolar injury, cytokine induction, and neutrophil accumulation, play key roles in the pathophysiology of acute lung injury (ALI). The immunomodulatory effects mesenchymal stem cells (MSCs) can contribute to treatment disorders. In previous studies, focus was on innate immune MSCs ALI through CD8 + T remain unclear. present study, lipopolysaccharide (LPS) used induce mice. mice were treated with via intratracheal instillation. Survival...
Abstract Objectives Acute lung injury (ALI) not only affects pulmonary function but also leads to intestinal dysfunction, which in turn contributes ALI. Mesenchymal stem cell (MSC) transplantation can be a potential strategy the treatment of However, mechanisms synergistic regulatory effects by MSCs on and intestine ALI need more in‐depth study. Materials methods We evaluated therapeutic murine model lipopolysaccharide (LPS)‐induced through survival rate, histopathology bronchoalveolar...
Abstract Background Loneliness in later life has been widely associated with poor mental and physical health. However, despite many reviews, current evidence does not provide a clear picture of how to tackle loneliness older adults through interventions. Research examining the contexts mechanisms for reducing interventions is required identify how, why, who work or do work. Methods A critical interpretive synthesis, review method designed rigorously reflexively re-examine existing...
// Yihua Bei 1,* , Yang Song 2,* Fei Wang 2 Jasmina Dimitrova-Shumkovska 1,3 Xiang 4 Yingying Zhao Jingqi Liu Junjie Xiao 1,5 and Changqing 1 Regeneration Ageing Lab, Experimental Center of Life Sciences, School Science, Shanghai University, Shanghai, China Division Gastroenterology Hepatology, Digestive Disease Institute, Tongji Hospital, University Medicine, 3 Department Biochemistry Physiology, Faculty Natural Sciences Mathematics, Ss Cyril Methodius, Skopje, Republic Macedonia State Key...
Background/Aims: MicroRNAs (miRNAs, miRs) have emerged as critical regulators of cancer cell proliferation. The effect miR-221 on growth could be significantly changeable in different lines. Although was reported to promote the pancreatic ductal adenocarcinoma (PDAC) cells, its role Capan-2 line is largely unknown. Methods: cells were transfected with mimics, inhibitors, or negative controls. Cell Counting Kit-8 used determine viability. EdU staining and cycle analysis measure Western...
The efficacy of mesenchymal stem cell (MSC)-based therapy for acute liver injury (ALI) involves coordination with the hepatic immune system, a complex and coordinated network immune-cell interactions. However, studies immunomodulatory effects MSCs have focused on limited number subsets rather than systematic assessment. Carbon tetrachloride (CCl4) was used to induce ALI in mice. To determine MSCs, mice were injected via tail vein, histopathological changes, survival rate, serum levels...
Abstract Background Immune system disorders play important roles in acute lung injury (ALI), and mesenchymal stem cell (MSC) treatment can reduce inflammation during ALI. In this study, we compared the changes B cells MSC treatment. Methods We investigated effects of MSCs on a mouse model lipopolysaccharide (LPS)-induced were administered intratracheally 4 h after LPS. As vehicle-treated controls, mice treated with phosphate-buffered saline (PBS) containing 2% C57BL/6 (PBS group)....
Rationale: Acute lung injury (ALI)-recruited mononuclear phagocytes play a pivotal role in and repair. This study investigated the types of recruited immunotherapeutic effects allograft mesenchymal stem cells (MSCs) mouse model lipopolysaccharide (LPS)-induced ALI. Methods: C57BL/6 mice were orotracheally instilled with LPS (20 mg/kg). Compact bone-derived MSCs administered 4 h after inhalation. Mononuclear tissues characterized at different timepoints by high-dimensional analysis including...
Nanosecond pulsed electric fields (nsPEFs) have emerged as a novel and effective strategy for the non-surgical minimally invasive removal of tumors. However, effects nsPEFs treatment on tumor immune microenvironment remain unknown. In this study, changes in morphology function pancreatic cancer cells after were assessed modifications profile models investigated. To end, electrodes inserted with different parameters applied to ablate targeted tissues. Tumor development was found be inhibited,...
Soil microorganisms are important components of agricultural ecosystems; they in soil nutrient cycle and easily affected by tillage. The response microbial community to tillage is very complex, the effect no residue mulching method on diversity remains unclear. In 2019, was collected from an experimental field after 10 years continuous cultivation black area Sanjiang Plain Northeastern China. this study, composition bacterial their relationship with properties were explored via...
Abstract Non‐alcoholic fatty liver disease ( NAFLD ), a lipid metabolism disorder characterized by the accumulation of intrahepatic fat, has emerged as global public health problem. However, its underlying molecular mechanism remains unclear. We previously have found that miR‐149 was elevated in induced high‐fat diet mice model, whereas decreased 16‐week running programme. Here, we reported increased HepG2 cells treated with long‐chain acid FFA ). In addition, able to promote lipogenesis...
Background . The mechanisms of mesenchymal stem cell (MSC) transplantation to protect against acute liver injury have been well studied within the liver. However, associated changes in intestinal microbiota during this process are poorly understood. Methods In study, compact bone-derived MSCs were injected into mice after carbon tetrachloride (CCl 4 ) administration. Potential curative effect MSC was evaluated by survival rate and biochemical pathological results. Overall structural...
Polymerase chain reaction (PCR) is the standard tool in genetic information analysis, and desirable detection merits of PCR have been extended to disease-related protein analysis. Recently, combination gold nanoparticles (AuNPs) construct colorimetric sensing platforms has received considerable attention due its high sensitivity, visual detection, capability for on-site low cost. However, it lacks a related review summarize discuss advances this area. This perspective gives an overview...
Drought severely affects the growth and yield of soybean plants especially during flowering period. To investigate effect 2-oxoglutarate (2OG) in combination with foliar nitrogen (N) at stage on drought resistance seed under stress. This experiment was conducted 2021 2022 drought-resistant variety (Hefeng 50) drought-sensitive 43) treated N (DS + N) 2OG) The results showed that stress significantly increased leaf malonaldehyde (MDA) content reduced per plant. However, superoxide dismutase...