As an alternative approach against multidrug-resistant bacterial infections, phages are now being increasingly investigated as effective therapeutic agents. Here, aiming to design efficient phage cocktail A. salmonicida we isolated and characterized five lytic phages, AS-szw, AS-yj, AS-zj, AS-sw, AS-gz. The results of morphological genomic analysis suggested that all these affiliated the T4virus genus Caudovirales order. Their heterogeneous capacities strains were demonstrated by...

Abstract The effects of land‐use changes on the runoff process in midstream plain this arid inland river basin are a key factor rational allocation water resources to middle and lower reaches. question is whether by how much increasingly heavy land use impacts hydrological processes such an basin. catchment Heihe River, one largest rivers region northwest China, was chosen investigate responses change. Flow duration curves were used detect trends variations between upper Relationships among...

Vibrio is one of the most detrimental agents shrimp premature death syndrome. Phage therapy for prevention and treatment infections has attracted increasing attentions due to emergence antibiotic-resistant bacterial variants. Here, we describe a workflow preparing phage cocktail against practical applications. Twenty strains were isolated from gut diseased aquaculture wastewater, five them identified as pathogens causing vibriosis. Twenty-two lytic phages then using above hosts, showed broad...

Colonization resistance is a fundamental mechanism by which microbiomes suppress pathogen invasion, yet the factors governing its efficacy remain unclear. By constructing defined microbial consortium and employing in vivo models, we provide evidence supporting that phage-mediated suppression interacts with competitive dynamics within communities to enhance colonization resistance. While individual species conferred limited protection, combining key taxa phage treatment extensively improved...

Phage therapy has been considered a potential alternative to antibiotic in treating bacterial infections. For controlling the vibriosis-causing pathogen Vibrio alginolyticus , well-documented phage candidates are still lacking. Here, we characterize novel lytic phage, ValSw3-3, based on its morphology, host range and infectivity, growth characteristics, stability under various conditions, genomic features. Our results show that ValSw3-3 could be potent candidate for treat V. infections due...

Comprehensive characterization of traditional Chinese medicine prescriptions has long been a hurdle due to the chemical complexity and lack analytical tools. Mahuang decoction is well-known prescription widely used for sweating relieving exterior, cough asthma, but it was insufficiently chemically scrutinized. In this study, component information investigated by ultrahigh-performance liquid chromatography tandem linear ion trap-Orbitrap mass spectrometry. A new data processing tool,...

With the increasing scale of applications and number users, we design a Self-organizing Cloud (SoC) which aims to make use distributed volunteer computers or dedicated machines provide powerful computing ability. These resources are provisioned elastically according user's specific demand, by leveraging virtual machine (VM) resource isolation technology. Based on such framework, propose social-optimized auction-based allocation scheme, mainly tackles two issues: (1) how full widely dispersed...

ABSTRACT OBJECTIVE Hyperproliferation of pulmonary artery smooth muscle cells (PASMCs) is one the essential features maladaptive inward remodeling arteries in arterial hypertension (PAH). In this study, we define mechanistic association between long-noncoding RNA: ENST00000495536 (Lnc-536) and anti-proliferative HOXB13 mediating hyperplasia. METHODS Antisense oligonucleotide-based GapmeRs or plasmid overexpressing lnc-536 were used to evaluate role hyperproliferation PDGF-treated idiopathic...

Rationale: The incidence of molar pregnancy in the cesarean scar is exceedingly low, however, disease may carry a high risk uncontrolled hemorrhage or uterine rupture. So far managements this were rarely reported literature. Patient concerns: We 28-year-old woman presented to our hospital with complaint amenorrhea for 48 days and vaginal bleeding 3 days. Diagnosis: Transvaginal ultrasonography, serum hCG pelvic MRI confirmed pregnancy. Interventions: patient underwent bilateral arterial...

Unit testing is a methodology for small parts of an application independently whatever uses them. It time consuming and tedious to write unit tests, it especially difficult tests that model the pattern usage application. Aspect-oriented programming (AOP) addresses problem separation concerns in programs which well suited test problems. What's more, should be made from different instead just functional assertions correctness or error. In this paper, we firstly present new concept,...

Vigorously developing nuclear power is the main development direction of current renewable energy. In environment, in order to avoid radiation damage maintenance personnel and improve efficiency reaction, it necessary urgent realize automatic replacement vulnerable parts electron gun. As key equipment for generation control reactions reactors, guns have been widely used plants traveling wave reactors. However, “high-voltage conductive ring” a part. It likely cause reactor accidents when part...

In recent years, the construction of Hercynian economic zone has been significantly paid attention by central government, as a whole developed rapidly, while condition competition and unbalanced development in different zones also appeared, become major obstacle for more healthy zone. Based on this background, article uses knowledge game theory to explore relationships between interest subjects zone, find out best model which all stakeholders can get maximum interests, then propose some...

Metaverse is one of the current hottest research fields, which not only requires rendering techniques such as path tracing but also engines Blender. However, scenes by a complex and computationally intensive process, especially for large scenes, causing catastrophically slow using single GPU.To improve performance, we use multiple GPUs to achieve parallel in Blender Cycles tracing. First, distribute workload based on pixel blocks. Each GPU renders image fragments finally combine results into...

Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Twitter Facebook Reddit LinkedIn Tools Reprints and Permissions Cite Search Site Citation Haiping Zhang, Qiuxiao Yin, Ling Chen; An Integrated Decision Support System for Water Quality Management of Songhua River Basin. AIP Conf. Proc. 24 November 2010; 1251 (1): 400–403. https://doi.org/10.1063/1.3529334 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote...

Exposure of bacterial populations to phage infection pressure is a significant driver phage-host co-evolution and diversification. However, the impact spatial organization population co-existence dynamics remains poorly understood. Here, we investigated how structure host affects interactions by co-cultivating Vibrio anguillarum strain with lytic T4-like vibriophage KVP40 under conditions that resulted in either homogenous, well-mixed or heterogeneous aggregates. We observed markedly...

Fetomaternal hemorrhage (FMH) result into severe, life-threatening fetal anemia and cause intrauterine death of the fetus. It is tough for an early diagnosis FMH before pregnancy few authors reported in a twin pregnancy. Therefore, we case massive FMH. The patient felt decrease movements at 33+5 gestational weeks. Cardiotocography showed sinusoidal heart rate patterns one hemoglobin level maternal blood was 6.4% (normal range single pregnancy, 0.0%-2.0%). Since diagnosed with distress,...