A5100879164- Mesenchymal stem cell research
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Respiratory Support and Mechanisms
- Ferroptosis and cancer prognosis
- Liver Diseases and Immunity
- Organ Transplantation Techniques and Outcomes
- Heavy metals in environment
- Model Reduction and Neural Networks
- Liver physiology and pathology
- Neurological Disease Mechanisms and Treatments
- Flavonoids in Medical Research
- Video Surveillance and Tracking Methods
- Neonatal Respiratory Health Research
- Nanoplatforms for cancer theranostics
- Metabolomics and Mass Spectrometry Studies
- Advanced Measurement and Detection Methods
- Heat Transfer and Optimization
- Fire Detection and Safety Systems
- Non-Destructive Testing Techniques
- Phagocytosis and Immune Regulation
- COVID-19 Clinical Research Studies
- Thermal properties of materials
- Heavy Metal Exposure and Toxicity
First Affiliated Hospital Zhejiang University
2021-2024
Zhejiang University
2020-2024
National Clinical Research Center for Digestive Diseases
2021-2024
University of Notre Dame
2023-2024
North University of China
2024
University of Electronic Science and Technology of China
2022
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2021
Abstract Mesenchymal stem cells (MSCs) have attracted interest for their potential to alleviate liver injury. Here, the protective effect of MSCs on carbon tetrachloride (CCl 4 )-induced acute injury (ALI) was investigated. In this study, we illustrated a novel mechanism that ferroptosis, newly recognized form regulated cell death, contributed CCl -induced ALI. Subsequently, based in vitro and vivo evidence MSC-derived exosomes (MSC-Exo) treatment achieved pathological remission inhibited...
Primary sclerosing cholangitis (PSC) is an autoimmune cholangiopathy characterized by chronic inflammation of the biliary epithelium and periductal fibrosis, with no curative treatment available, liver transplantation inevitable for end-stage patients. Human placental mesenchymal stem cell (hpMSC)-derived exosomes have demonstrated ability to prevent inhibit collagen production possess immunomodulatory properties in disease. Here, we prepared hpMSC-derived (ExoMSC) further investigated...
Background and Aims: The immunomodulatory characteristics of mesenchymal stem cells (MSCs) make them a promising therapeutic approach for liver fibrosis (LF). Here, we postulated that MSCs could potentially suppress the pro-fibrotic activity intrahepatic B cells, thereby inhibiting LF progression. Approach Results: Administration significantly ameliorated as indicated by reduced myofibroblast activation, collagen deposition, inflammation. treatment efficacy can be attributed to decreased...
Abstract Acute lung injury (ALI) is an inflammatory disease associated with alveolar injury, subsequent macrophage activation, cell infiltration, and cytokine production. Mesenchymal stem cells (MSCs) are beneficial for application in the treatment of diseases due to their immunomodulatory effects. However, mechanisms regulatory effects by MSCs on macrophages ALI need more in-depth study. Lung tissues were collected from mice mouse organoid construction. Alveolar (AMs) derived...
Abstract Objectives Acute lung injury (ALI) not only affects pulmonary function but also leads to intestinal dysfunction, which in turn contributes ALI. Mesenchymal stem cell (MSC) transplantation can be a potential strategy the treatment of However, mechanisms synergistic regulatory effects by MSCs on and intestine ALI need more in‐depth study. Materials methods We evaluated therapeutic murine model lipopolysaccharide (LPS)‐induced through survival rate, histopathology bronchoalveolar...
Acute liver injury (ALI) is characterized by massive hepatocyte necrosis and subsequent recruitment of myeloid cells to liver. Mesenchymal stem (MSCs) have therapeutic potential for ALI through their immunoregulation on macrophages, but the mechanism not completely clear due heterogeneity controversy macrophages. Here, we detected survival rate, biochemical indexes, histopathology, inflammatory chemokine levels assess efficacy MSC treatment CCl4-induced C57BL/6 mice. Furthermore, flow...
Primary sclerosing cholangitis (PSC) is a biliary disease accompanied by chronic inflammation of the liver and stricture. Mesenchymal stem cells (MSCs) are used to treat diseases because their immune regulation regeneration-promoting functions. This study was performed explore therapeutic potential human placental MSCs (hP-MSCs) in PSC through Takeda G protein-coupled receptor 5 (TGR5) pathway. Liver tissues were collected from patients with healthy donors (n = 4) for RNA sequencing...
Rationale: Acute lung injury (ALI)-recruited mononuclear phagocytes play a pivotal role in and repair. This study investigated the types of recruited immunotherapeutic effects allograft mesenchymal stem cells (MSCs) mouse model lipopolysaccharide (LPS)-induced ALI. Methods: C57BL/6 mice were orotracheally instilled with LPS (20 mg/kg). Compact bone-derived MSCs administered 4 h after inhalation. Mononuclear tissues characterized at different timepoints by high-dimensional analysis including...
Abstract Non-diffusive phonon transport presents significant challenges in micro/nanoscale thermal characterization, compounded by the limitations of experimental-numerical techniques and presence measurement noise. Additionally, inverse modeling uncertainty quantification for submicron remain under-explored. In this study, we introduce a physics-informed Bayesian deep learning framework designed to address Boltzmann equation (BTE)-based forward problems leveraging limited noisy data. Our...
As human placenta-derived mesenchymal stem cells (hP-MSCs) exist in a physiologically hypoxic microenvironment, various studies have focused on the influence of hypoxia. However, underlying mechanisms remain to be further explored.The aim was reveal possible by which hypoxia enhances proliferation hP-MSCs.A cell incubator (2.5% O2) used mimic microenvironment. Cell counting kit-8 and 5-ethynyl-20-deoxyuridine incorporation assays were assay hP-MSCs. The cycle profiled flow cytometry....
With the rapid advancement of deep learning, this technique has also shown promise in single-object tracking, considerably enhancing algorithm's performance. This paper will summarize and analyze evaluation metrics, public datasets, state-of-the-art tracking methods, etc. It classify research status key technologies involved reveal mystery single object technology step by step. In addition, significant challenges problems are summarized.
The effect of hypoxia on mesenchymal stem cells (MSCs) is an emerging topic in MSC biology. Although long non-coding RNAs (lncRNAs) and messenger (mRNAs) are reported to play a critical role regulating the biological characteristics MSCs, their specific expression co-expression profiles human placenta-derived MSCs (hP-MSCs) under underlying mech anisms lncRNAs hP-MSC biology unknown.To reveal hP-MSCs initially explored possible mechanism biology.Here, we used multigas incubator (92.5% N2, 5%...
Baicalin and baicalein are the primary flavonoids derived from desiccated root of Scutellaria baicalensis, which is a member Lamiaceae family; these have diverse pharmacological properties show significant potential for management central nervous system disorders. Multiple studies indicated that substances effectively reduce severity illnesses such as depression, stroke, degenerative disorders disordersby exerting antioxidant anti-inflammatory effects, regulating programmed cell death,...
The tracker based on the Siamese network describes object-tracking task as a similarity-matching problem. is current mainstream model. It achieves similarity learning by applying correlation filters to target and search branches’ convolution features. However, because operation uses local linear matching process, semantic information lost, it simple run into issue of optimality. Transformer Tracking has recently been proposed using an attention-based feature fusion instead previous achieve...
Abstract Background: Ferroptosis, a newly recognized form of regulated cell death, was recently identified as novel therapeutic target in tissue injury. Various studies have shown that administration mesenchymal stem cells (MSC) is promising approach to repair liver However, the role ferroptosis acute injury (ALI) and MSC-based therapy unknown. Results: Here we found CCl 4 induced elevated lipid reactive oxygen species (lipid-ROS) mRNA levels putative molecular markers such Ptgs2 LOX genes....