A5054423927- Advanced biosensing and bioanalysis techniques
- Molecular Sensors and Ion Detection
- Luminescence and Fluorescent Materials
- DNA and Nucleic Acid Chemistry
- Nanoplatforms for cancer theranostics
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Protein Degradation and Inhibitors
- RNA Interference and Gene Delivery
- Click Chemistry and Applications
- Sulfur Compounds in Biology
- Biosensors and Analytical Detection
- Metal complexes synthesis and properties
- Peptidase Inhibition and Analysis
- Ubiquitin and proteasome pathways
- Multiple Myeloma Research and Treatments
- Lanthanide and Transition Metal Complexes
- Cancer-related Molecular Pathways
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Cancer therapeutics and mechanisms
- Neuropeptides and Animal Physiology
- Cytokine Signaling Pathways and Interactions
Northwestern Polytechnical University
2020-2025
Hong Kong Baptist University
2015-2023
South China Institute of Collaborative Innovation
2021-2023
Jilin University
2013-2023
City University of Hong Kong
2020-2021
City University of Hong Kong, Shenzhen Research Institute
2020-2021
Kowloon Hospital
2016-2020
The People's Hospital of LinXia
2017
This review describes recent examples of cyclometalated iridium(<sc>iii</sc>) metal complexes that act as luminescent chemosensors for cations, anions or small molecules.
Abstract Impaired wound healing and ulcer complications are a leading cause of death in diabetic patients. In this study, we report the design synthesis cyclometalated iridium(III) metal complex 1a as stabilizer hypoxia-inducible factor-1α (HIF-1α). vitro biophysical cellular analyses demonstrate that compound binds to Von Hippel-Lindau (VHL) inhibits VHL–HIF-1α interaction. Furthermore, accumulates HIF-1α levels cellulo activates mediated gene expression, including VEGF , GLUT1 EPO . vivo...
β-Galactosidase (β-gal) is an important biomarker for ovarian cancers. In this work, we designed and synthesized a novel iridium(III)-based probe 1 discriminating carcinoma cell lines from normal lines. The could detect β-gal even in the presence of highly autofluorescent background. also showed good linear response to between 0 30 U/mL, with detection limit 0.51 U/mL. Importantly, complex selectively "light up" cells, while exhibiting negligible luminescence cells. Overall, be potentially...
Lysine-specific demethylase 5A (KDM5A) has recently become a promising target for epigenetic therapy. In this study, we designed and synthesized metal complexes bearing ligands with reported p27 modulating activities. The Rh(III) complex 1 was identified as direct, selective potent inhibitor of KDM5A that directly abrogate activity via antagonizing the KDM5A-tri-/di-methylated histone 3 protein-protein interaction (PPI) in vitro cellulo. Complex induced accumulation H3K4me3 H3K4me2 levels...
This study reports the first use of an iridium(<sc>iii</sc>) compound and its enantiomer to inhibit H-Ras/Raf-I PPI <italic>in vitro</italic> repress renal cancer xenografts vivo</italic>.
A novel luminescent cyclometalated iridium(III) complex was synthesized and employed as a chemosensor for the detection of Al(3+) ions. Compared with common organic chemosensors, displays larger Stokes shift long lifetime luminescence that allow to detect ions in fluorescent dye spiked strong fluorescence media potentially be used strongly autofluorescent biological samples.
In this study, an unreported Ir(III) complex 1 was identified by screening as a versatile G-quadruplex probe. It exhibited highly selective response for different DNA over double strand, single strand and triplex DNA. Compared with the organic probe thioflavin T, displays longer lifetime, larger Stokes shift, comparable G-quadruplex/ssDNA enhancement ratios, higher G-quadruplex/triplex ratios. consideration of encouraging performance 1, we employed to develop G-quadruplex-based detection...
Iridium(III) complexes are emerging as a promising tool in the area of detection and therapy due to their prominent photophysical properties, including higher photostability, tunable phosphorescence emission, long-lasting phosphorescence, high quantum yields. In recent years, much effort has been devoted develop novel near-infrared (NIR) iridium(III) improve signal-to-noise ratio enhance tissue penetration. this review, we summarize different classes organometallic NIR for therapy,...
We report herein the identification of rhodium(III) complex [Rh(phq)2(MOPIP)]+ (1) as a potent and selective ATP-competitive neural precursor cell expressed, developmentally down-regulated 8 (NEDD8)-activating enzyme (NAE) inhibitor. Structure–activity relationship analysis indicated that overall organometallic design 1 was important for anti-inflammatory activity. Complex showed promising activity in vivo potential treatment inflammatory bowel disease.
We report herein a novel rhodium(III) complex 1 as new LSD1 targeting agent and epigenetic modulator. Complex disrupted the interaction of LSD1-H3K4me2 in human prostate carcinoma cells enhanced amplification p21, FOXA2, BMP2 gene promoters. was selective for over other histone demethylases, such KDM2b, KDM7, MAO activities, also showed antiproliferative activity toward cancer cells. To date, is first metal-based inhibitor activity.
Formyl peptide receptors play important biological and therapeutic roles in wound repair inflammatory diseases.
Cyclin-dependent kinase 9 (CDK9) activity is correlated with worse outcomes of triple-negative breast cancer (TNBC) patients. The heterodimer between CDK9 cyclin T1 essential for maintaining the active state and targeting this protein–protein interaction (PPI) may offer promising avenues selective inhibition. Herein, we designed generated a library metal complexes bearing 7-chloro-2-phenylquinoline CˆN ligand tested their against CDK9–cyclin PPI. Complex 1 bound to via an...
Abstract Breast cancer (BC) is the most frequent malignant diagnosis and a primary factor for deaths in women. The clinical subtypes of BC include estrogen receptor (ER) positive, progesterone (PR) human epidermal growth 2 (HER2) triple-negative (TNBC). Based on stages BC, various treatment methods are available with variations rates progression-free disease overall survival patients. However, still faces challenges, particularly terms drug resistance recurrence. study epigenetics has...
In this work, the iridium(<sc>iii</sc>) complex <bold>1</bold> was synthesized and employed in constructing an assay which is based on a G-quadruplex for detecting arsenic ions aqueous solution.
Two luminescent iridium(iii) complexes, 1 and 2, were synthesized evaluated for their ability to probe COX-2 in human cancer cells. This is the first application of complexes as imaging agents COX-2. We demonstrate that complex differentiates cells from normal with high stability low cytotoxicity.
The novel iridium(III) complex 1 was verified as a potent inhibitor of the TNF-α-TNFR protein-protein interaction in vitro and cellulo. center plays critical role organizing structure bioactive metal complex, isolated ligands were found to be completely inactive. Both iridium enantiomers inhibited TNF-α-induced NF-κB activity binding. represents promising scaffold for further development more organometallic TNF-α inhibitors.
Gastrin-releasing peptide receptor (GRPr) plays proliferative and inflammatory roles in living systems. Here, we report a highly selective GRPr antagonist (JMV594)-tethered iridium(III) complex for probing cancer cells immune cells. This probe exhibited desirable photophysical properties also displayed negligible cytotoxicity, overcoming the inherent toxicity of complex. Its long emission lifetime enabled its luminescence signal to be readily distinguished from interfering fluorescence...
Hybrid upconversion nanosystems have been reported to improve the low absorption efficiency of lanthanide-doped nanoparticles (UCNPs). However, quantum yield and poor photostability NIR dyes pose challenges for practical uses. Here, we introduce a bulky moiety, 4-(1,2,2-triphenylvinyl)-1,1′-biphenyl (TPEO), enhance its by suppressing bond rotation stability deactivating photoinduced oxidization. Compared with conventional IR806, formed dye, TPEO-Cy, has characterized deliver three times...
Hepatotoxicity caused by an overdose of acetaminophen (APAP) is the leading reason for acute drug-related liver failure. Nuclear factor erythroid-2-related 2 (Nrf2) a protein that helps to regulate redox homeostasis and coordinate stress responses via binding Kelch-like ECH-associated 1 (Keap1). Targeting Keap1-Nrf2 interaction has recently emerged as potential strategy alleviate injury APAP. Here, we designed synthesized number iridium (III) rhodium complexes bearing ligands with reported...