A5100607860- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Electrochemical sensors and biosensors
- RNA Interference and Gene Delivery
- Nanocluster Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Carbon and Quantum Dots Applications
- Electrochemical Analysis and Applications
- Molecular Sensors and Ion Detection
- Gold and Silver Nanoparticles Synthesis and Applications
- DNA and Nucleic Acid Chemistry
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Cancer-related gene regulation
- Bacteriophages and microbial interactions
- Nanocomposite Films for Food Packaging
- Advanced Biosensing Techniques and Applications
- Essential Oils and Antimicrobial Activity
- Luminescence and Fluorescent Materials
- SARS-CoV-2 detection and testing
- Analytical Chemistry and Sensors
- Conducting polymers and applications
- Plant Pathogens and Fungal Diseases
- Molecular Junctions and Nanostructures
Jiangsu Normal University
2016-2025
Hong Kong Baptist University
2016-2021
Xuzhou University of Technology
2016
Sun Yat-sen University
2011-2012
State Key Laboratory of Chemical Engineering
2011
Southwest University
2007-2008
Chongqing University
2007
A novel multifunctional polymeric micelle bearing a pH-tunable on-off module for programmed drug release, folate tumor targeting, and quantum dots fluorescent imaging is described. The can turn release off at neutral pH whereas on inside lysosomes. QD functionalization allows clear elucidation of facile visualization in vivo delivery event. Detailed facts importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset....
A novel strategy was developed for microRNA-155 (miRNA-155) detection based on the fluorescence quenching of positively charged gold nanoparticles [(+)AuNPs] to Ag nanoclusters (AgNCs). In designed system, DNA-stabilized (DNA/AgNCs) were introduced as fluorescent probes, and DNA–RNA heteroduplexes formed upon addition target miRNA-155. Meanwhile, (+)AuNPs could be electrostatically adsorbed negatively single-stranded DNA (ssDNA) or quench signal. presence duplex-specific nuclease (DSN),...
Lysine-specific demethylase 5A (KDM5A) has recently become a promising target for epigenetic therapy. In this study, we designed and synthesized metal complexes bearing ligands with reported p27 modulating activities. The Rh(III) complex 1 was identified as direct, selective potent inhibitor of KDM5A that directly abrogate activity via antagonizing the KDM5A-tri-/di-methylated histone 3 protein-protein interaction (PPI) in vitro cellulo. Complex induced accumulation H3K4me3 H3K4me2 levels...
A dynamic light scattering sensor for Pb(2+) was constructed with oligonucleotide-modified gold nanoparticles based upon its cleavage property DNAzyme.
Abstract Positively charged gold nanoparticles (+)AuNPs can adsorb onto the negatively surface of single-stranded DNA (ssDNA) or double-stranded (dsDNA). Herein, long-range dsDNA polymers could form based on hybridization chain reaction (HCR) two hairpin probes (H 1 and H 2 ) by using miRNA-21 as an initiator. such electrostatic adsorption, which directly resulted in precipitation decrease absorption spectra. Under optimal conditions, detection be realized range 20 pM-10 nM with a limit 6.8...
A fluorescent biosensor for sequence-specific recognition of double-stranded DNA (dsDNA) was developed based upon the hybridization between dye-labeled single-stranded (ssDNA) and DNA. The fluorescence FAM-labeled quenched when it adsorbed on surface graphene oxide (GO). Upon addition target dsDNA, a homopyrimidine·homopurine part dsDNA Simian virus 40 (SV40) (4424–4440, gp6), occurred which induced desorbed from GO, turned dye. Under optimum conditions, enhanced intensity proportional to...