A5059820497- Cellular Mechanics and Interactions
- Cellular transport and secretion
- Functional Brain Connectivity Studies
- Developmental Biology and Gene Regulation
- RNA Research and Splicing
- Genomics and Phylogenetic Studies
- Machine Learning in Bioinformatics
- Neuroscience and Neuropharmacology Research
- Immune Response and Inflammation
- Muscle Physiology and Disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Metabolomics and Mass Spectrometry Studies
- Reproductive System and Pregnancy
- Attachment and Relationship Dynamics
- Reproductive Biology and Fertility
- Treatment of Major Depression
- Genomics and Chromatin Dynamics
- Pancreatic and Hepatic Oncology Research
- Advanced Neuroimaging Techniques and Applications
- Adenosine and Purinergic Signaling
- Gut microbiota and health
- Peptidase Inhibition and Analysis
- Wnt/β-catenin signaling in development and cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Hearing, Cochlea, Tinnitus, Genetics
Renji Hospital
2025
Shanghai Jiao Tong University
2025
Jiangxi Science and Technology Normal University
2015-2024
Zhumadian Central Hospital
2019-2024
First Affiliated Hospital of Jiangxi Medical College
2023-2024
Jiangxi Provincial People's Hospital
2022-2024
Beijing University of Agriculture
2010-2023
Southeast University
2021-2023
Nanchang University
2016-2022
People’s University
2022
The major environmental determinants of honeybee caste development come from larval nutrients: royal jelly stimulates the differentiation larvae into queens, whereas beebread leads to worker bee fate. However, these are not fully characterized. Here we report that plant RNAs, particularly miRNAs, which more enriched in than jelly, delay and decrease body ovary size honeybees, thereby preventing queens inducing bees. Mechanistic studies reveal amTOR, a stimulatory gene differentiation, is...
Abstract Background Obese and lean pig breeds show obvious differences in muscle growth; however, the molecular mechanism underlying phenotype variation remains unknown. Prenatal development programs postnatal performance. Here, we describe a genome-wide analysis of prenatal skeletal between Tongcheng (a typical indigenous Chinese breed) Landrace leaner Western pigs. Results We generated transcriptome profiles from pigs at 33, 65 90 days post coitus (dpc), using long serial gene expression...
Abstract Extracellular purinergic products, particularly ATP, have recently been implicated to regulate immune cell functions and contribute aberrant inflammatory responses of diseases. However, regulation colitis by extracellular ATP its main receptor, P2 × 7, remains be elucidated. In the study, we induced murine feeding mice with 4% dextran sulfate sodium (DSS) noted dramatically heightened levels in colon tissues during progression experimental colitis. Blockade release carbenoxolone...
Abstract As one of the Ras‐associated proteins, Rap1A has been linked to cancer initiation and development. However, precise function in ovarian is still not understood. Here, we show that promotes tumorigenesis metastasis via stimulating cell proliferation, migration invasion both vivo vitro. Mechanistic study showed activates extracellular signal‐regulated kinase ( ERK ), p38 mitogen‐activated protein MAPK ) Notch pathways, leading enhanced expression several epithelial‐mesenchymal...
Abstract Recently, a new coronavirus was isolated from the lung tissue of autopsy sample and nasal/throat swabs patients with Severe Acute Respiratory Syndrome (SARS) causative association SARS determined. To reveal further characteristics virus to provide insight about molecular mechanism etiology, proteomic strategy utilized identify structural proteins (SARS‐CoV) Vero E6 cells infected BJ‐01 strain virus. At first, Western blotting convalescent sera demonstrated that there were various...
During Drosophila oogenesis, two actin dynamics regulators, cofilin and Rac, are required for the collective migration of a coherent cluster cells called border cells. Cell culture data have shown that Rac both essential lamellipodium formation, but signaling results in phosphorylation hence inactivation cofilin. So it remains unclear whether plays promoting or inhibitory role during cell migration. We show here is F-actin turnover lamellipodial protrusion Interestingly, reducing dosage by...
Lipid nanoparticles (LNPs) have revolutionized nucleic acid delivery, enabling significant advances in mRNA-based therapeutics. While extensive research has focused on lipid composition, the impact of preparation solutions LNP performance remains underexplored. This study systematically investigated effects pH, salt type, and concentration across key solutions—mRNA aqueous, dilution, exchange, storage solutions—on physicochemical properties, stability, expression efficiency SM102-based...
To explore the contribution of single-gene defects to genetic cause cardiac left-sided lesions (LSLs), and evaluate incremental diagnostic yield whole-exome sequencing (WES) for in fetuses with LSLs without aneuploidy or a pathogenic copy-number variant (pCNV).Between 10 April 2015 30 October 2018, we recruited 80 pregnant women diagnosed LSL who had termination pregnancy testing. Eligible were aortic valve atresia stenosis, coarctation aorta, mitral stenosis hypoplastic left heart syndrome...
Background Schizophrenia is a complex mental disorder with high heritability and polygenic inheritance. Multimodal neuroimaging studies have also indicated that abnormalities of brain structure function are plausible neurobiological characterisation schizophrenia. However, the effects schizophrenia on these imaging endophenotypes not yet been fully elucidated. Aims To investigate risk for grey matter volume functional connectivity, which disrupted in Method Genomic data from large sample Han...
Although oligonucleotide chips, cDNA microarrays, differential display reverse transcription-PCR, and other approaches have been used to screen implantation-related molecules, the mechanism by which embryo implantation occurs is still unknown. The aim of this study was profile gene expression between interimplantation site in mouse uterus on day 5 pregnancy serial analysis (SAGE). In our two SAGE libraries 11-bp tags, total numbers tags sequenced were 48,121 for 50,227 site. There 1,039...
Abstract Kv2.1 as a voltage-gated potassium (Kv) channel subunit has pivotal role in the regulation of glucose-stimulated insulin secretion (GSIS) and pancreatic β -cell apoptosis, is believed to be promising target for anti-diabetic drug discovery, although mechanism underlying Kv2.1-mediated apoptosis obscure. Here, small molecular compound, ethyl 5-(3-ethoxy-4-methoxyphenyl)-2-(4-hydroxy-3-methoxybenzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2–a]pyrimidine-6-carboxylate...
Background: Major depressive disorder (MDD) is associated with a wide range of cognitive deficits. However, it remains unclear whether there will be major deficit independently caused by depression at acute episodes MDD. Methods: A comprehensive neurocognitive test battery was used to assess the executive function, processing speed, attention and memory in 162 MDD patients 142 healthy controls (HCs). multivariate analysis variance, hierarchical regression analyses general linear were explore...
Previous studies have shown the role of bacterial lipopolysaccharide (LPS) in promoting tumor progression. Our previous study found that community richness LPS-producing bacteria was significantly increased fresh stool samples esophageal cancer (EC) patients, but relative LPS levels and underlying mechanism EC progression remain unknown. In this study, an case-control content higher serum patients. Functional experiments CCK8 assay transwell showed contributed to proliferation, migration,...
During epithelial morphogenesis, cells not only maintain tight adhesion for integrity but also allow dynamic intercellular movement to take place within cell sheets. How these seemingly opposing processes are coordinated is well understood. Here, we report that the actin disassembly factors AIP1 and cofilin required remodeling of adherens junctions (AJs) during ommatidial precluster formation in Drosophila eye epithelium, a highly stereotyped rearrangement process which describe detail our...
Species identification via DNA barcodes is contributing greatly to current bioinventory efforts. The initial, and widely accepted, proposal was use the protein-coding cytochrome c oxidase subunit I (COI) region as standard barcode for animals, but recently non-coding internal transcribed spacer (ITS) genes have been proposed candidate both animals plants. However, achieving a robust alignment regions can be problematic. Here we propose two new methods (DV-RBF FJ-RBF) address this issue...
Abstract In mammals, spermatogonial stem cells (SSCs) arise from early germ called gonocytes, which are derived primordial during embryogenesis and remain quiescent until birth. After birth, these migrate the center of testicular cord, through Sertoli cells, toward basement membrane to form SSC pool establish niche architecture. However, molecular mechanisms underlying cell migration establishment largely unknown. Here, we show that actin disassembly factor interacting protein 1 (AIP1) is...
Multi-modality of pI distribution is a common feature in different whole proteomes. Some researchers considered it relate to the proteins with subcellular locations, indicating result natural selection. We explored predicted proteomes (including animals, plants, bacterium, archaeans) and random proteome [random protein sequences constructed according special amino acid composition molecular weight (MW) human proteome]. Our results suggest that multi-modality discrete pK(R) values for acids....
Edaravone was launched in Japan 2001 and the first neuroprotectant developed for treatment of acute cerebral infarction. is mainly eliminated as glucuronide conjugate human urine (approximately 70%), but mechanism involved elimination pathway remains unidentified. We investigated glucuronidation edaravone liver microsomes (HLM) kidney (HKM) identified major hepatic renal UDP-glucuronosyltransferases (UGTs) involved. As we observed, HLM HKM exhibited biphasic kinetics. The intrinsic clearance...
During collective migration, guidance receptors signal downstream to result in a polarized distribution of molecules, including cytoskeletal regulators and themselves, response an extracellular gradient chemotactic factors. However, the underlying mechanism asymmetry generation context migration group cells is not well understood. Using border Drosophila ovary as model system for we found that receptor tyrosine kinase (RTK) PDGF/VEGF (PVR) required recycling endosome exocyst leading cell...
The aim of the study was to develop a physiologically based pharmacokinetic (PBPK) model rhein predict human pharmacokinetics before dosing for first time in beings. After oral administration at doses 35, 70 and 140 mg/kg rat, had following mean plasma properties: t1/2 3.2, 3.6 4.3 hr, AUC∞ 69.5, 164.3 237.8 μg/h/ml CL/F 503.4, 426.1 588.8 ml/hr/kg, respectively. In vitro, intrinsic clearance (Clint) cytochrome P450 (CYP450), UDP-glucuronosyltransferase (UGT) sulfotransferase (SULT)...
Dysfunctional attitudes play a key role in the development and prognosis of depression. Gender also plays an important many clinical features major depressive disorder (MDD). This study is aimed at investigating gender differences dysfunctional patients with MDD.One hundred seventy-two MDD 159 healthy controls (HCs) were enrolled this study. assessed by Chinese version attitude scale-form A (C-DAS-A) depression severity was 24-item Hamilton rating scale for (HAMD24). The 14-item Anxiety...
Nontarget data acquisition for target analysis (nDATA) workflows using liquid chromatography-high-resolution accurate mass (LC-HRAM) spectrometry, spectral screening software, and a compound database have generated interest because of their potential pesticides in foods. However, these procedures particularly the instrument processing software need to be thoroughly evaluated before implementation routine analysis. In this work, 25 laboratories participated collaborative study evaluate an...