A5100428314- Prostate Cancer Treatment and Research
- Cancer, Lipids, and Metabolism
- Lung Cancer Treatments and Mutations
- Renal cell carcinoma treatment
- Prostate Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Radiopharmaceutical Chemistry and Applications
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Microtubule and mitosis dynamics
- Ubiquitin and proteasome pathways
- Estrogen and related hormone effects
- Biliary and Gastrointestinal Fistulas
- Pediatric Hepatobiliary Diseases and Treatments
- Wound Healing and Treatments
- Cancer-related molecular mechanisms research
- Urologic and reproductive health conditions
- Gallbladder and Bile Duct Disorders
- Renal and related cancers
- Orthopaedic implants and arthroplasty
- Cerebrovascular and Carotid Artery Diseases
- Hip disorders and treatments
- Radiomics and Machine Learning in Medical Imaging
- Angiogenesis and VEGF in Cancer
- Metastasis and carcinoma case studies
Nanjing Drum Tower Hospital
2017-2025
Shanxi Medical University
2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2023-2025
Chongqing Medical University
2023-2025
Renji Hospital
2025
Shaanxi Provincial People's Hospital
2025
Shanghai Jiao Tong University
2025
SUNY Upstate Medical University
2019-2024
Neurological Surgery
2024
Wenzhou Medical University
2017-2024
The tricarboxylic acid (TCA) cycle is capable of providing sufficient energy for the physiological activities under aerobic conditions. Although tumor metabolic reprogramming places glycolysis in a dominant position, TCA remains indispensable cells as hub linkage and interconversion glucose, lipids, certain amino acids. intermediates such citrate, α-ketoglutarate, succinate, fumarate are altered tumors, they regulate metabolism, signal transduction, immune environment to affect tumorigenesis...
Abstract Hormone therapy drugs, such as bicalutamide and enzalutamide, directed against prostate cancer focus on androgen receptor (AR) signaling are initially effective, but the disease progresses to lethality resistance these drugs develops. A method prolong drug response time improve efficacy is still unavailable. TRIM36 was reported a novel target gene upregulated in cancer. In this study, we found that 63.4% (64/95) of PCa TMA expressed protein. Interestingly, patients with negative...
Neuroendocrine prostate cancer (NEPC), the most lethal subtype of castration-resistant (PCa), may evolve from neuroendocrine differentiation (NED) PCa cells. However, molecular mechanism that triggers NED is unknown. Trigred motif 36 (TRIM36), a member TRIM protein family, exhibits oncogenic or anti-oncogenic roles in various cancers. We have previously reported TRIM36 highly expressed to inhibit invasion and proliferation PCa. In present study, we first found was lowly NEPC its...
Proximal junctional kyphosis (PJK) is a common complication of deformity correction for degenerative kyphoscoliosis (DKS) with an incidence between 20% and 40%. Multiple techniques have been proposed to prevent PJK, however, the clinical efficacy these remains unclear. Here, we investigate influence thoracic tri-cortical pedicle screw (TPS) in most cranial instrumented segment on PJK. To evaluate outcomes mechanical complications corrective surgery DKS at minimum 2-year follow-up using TPS...
To investigate the efficacy of endostar combined with simultaneous chemoradiotherapy versus conventional treatment methods for locally advanced cervical cancer (LACC) and assess prognosis these patients. A retrospective analysis was conducted on medical records 182 LACC patients treated at Shaanxi Provincial Cancer Hospital between January 2017 February 2021. Of these, 88 underwent synchronous (control group), while 94 received (combined group). Treatment efficacy, adverse reactions, tumor...
m6A, m5C and m7G are common types of RNA methylation modifications that widely involved in key mechanisms regulating malignancy. However, the role methylation-related genes immune microenvironment bladder cancer (BLCA) remains elusive. In this study, we established molecular subtypes by analyzing TCGA GEO datasets. Risk model nomogram were constructed LASSO multivariate Cox regression analysis validated external Genetic variations, functional enrichment cell infiltration analyzed. The...
Lipid nanoparticles (LNPs) have revolutionized nucleic acid delivery, enabling significant advances in mRNA-based therapeutics. While extensive research has focused on lipid composition, the impact of preparation solutions LNP performance remains underexplored. This study systematically investigated effects pH, salt type, and concentration across key solutions—mRNA aqueous, dilution, exchange, storage solutions—on physicochemical properties, stability, expression efficiency SM102-based...
Abstract Background Ubiquitylation modification is one of the multiple post-transcriptional process to regulate cellular physiology, including cell signaling, cycle regulation, DNA repair and transcriptional regulation. Members TRIM family proteins could be defined as E3 ubiquitin ligases they contain a RING-finger domain, alterations are involved into broad range diverse disorders cancer. TRIM37 novel discovered ligase acts oncoprotein in human neoplasms, however its biological role RCC...
Limb and CNS expressed 1 like (LIX1L) is over-expressed in several types of tumors. However, the function LIX1L glucose metabolism hepatocellular carcinoma (HCC) progression remains elusive. Here we report that human HCC tissues, which predicts unfavorable prognosis. deficiency vivo significantly attenuated liver cancer initiation mice. Functional studies indicated overexpression elevated proliferation, migratory, invasive capacities cells vitro, promoted growth metastasis vivo. knockdown...
This study investigated the effects of compound probiotics (CP) on AFB
Genetic variations in a PTEN/AKT/mTOR signaling axis may influence cellular functions including cell growth, proliferation and apoptosis, then increase the individual's risk of cancer. Accordingly, we explore association between single nucleotide polymorphisms (SNPs) these genes prostate cancer (PCa) our Chinese population.Subjects were recruited from 666 PCa patients 708 cancer-free controls, eight SNPs determined by TaqMan assay. Odds ratios (OR) 95% confidence intervals (95% CI) evaluated...
Abstract Combat injuries are associated with a high incidence of infection, and there is continuing need for improved approaches to control infection promote wound healing. Due the possible local systemic adverse effects standard 1% cream formulation (Silvadene), we had previously developed polyethylene glycol ( PEGylated ) fibrin hydrogel FPEG )‐based dressing controlled delivery silver sulfadiazine SSD entrapped in chitosan microspheres CSM ). In this study, have evaluated antimicrobial...
To compare the mid-long-term clinical and radiological outcomes between a combination of cortico-cancellous iliac bone graft with vascularized greater trochanter flap (Group A) isolate B) in treatment Osteonecrosis Femoral Head (ONFH).
The role of
The mRNA expression of CAPN2 was upregulated in CRPC cells (DU145 and PC3) than that non-CRPC cells. Silencing could inhibit DU145 PC3 proliferation by cell cycle arrest at G1 phase. Knockdown CPAN2 level suppressed the migration invasion capacity reducing matrix metalloproteinase-2 (MMP-2) MMP-9 activation, as well repressing phosphorylation protein AKT mTOR. In addition, we found elevated Pca tissues normal control tissues. Therefore, showed important roles development progression cells,...
Background The RhoA/ROCK pathway and Caveolin-1 (Cav-1) participate in the process of tumorigenesis numerous types cancer. Up-regulation Cav-1 expression is considered to be associated with development progression clear cell renal carcinoma (ccRCC). We investigated association between genetic variations risk ccRCC Chinese population. Methods Between May 2004 March 2014, a total 1,248 cases 1,440 cancer-free controls were enrolled this hospital-based case-control study. Nine SNPs genotyped...
We aimed to evaluate the clinical and radiological short-medium term outcomes for treatment of bilateral osteonecrosis femoral head (ONFH) with hip-preserving surgery core decompression followed by tightly impaction bone grafting combining non-vascularized fibular allografting in one hip concurrent one-stage total arthroplasty (THA) contralateral side. hypothesized aforementioned showed benefits protecting preserved from collapsing thereafter THA was delayed or avoided.We retrospectively...
BACKGROUND Worldwide, ovarian cancer has a high mortality rate due to the difficulty in diagnosing early-stage disease and resistance chemotherapy agents. Costunolide is plant-derived sesquiterpene lactone with anti-oxidant properties. This study aimed investigate effects of costunolide on cell growth, apoptosis, autophagy, production reactive oxygen species (ROS), cleaved caspase-3, caspase-9 multidrug-resistant line, OAW42-A. MATERIAL AND METHODS The MTT assay determined proliferation...
Prostate cancer is the most common male malignancies in United States. The specific characteristics of different disease stages have been deeply investigated. We present our data on ALDH1A3 as a potential therapeutic target for prostate based several functional investigations. Also, we used Cancer Genome Atlas datasets primary to detect relevance and luminal phenotype. found that correlated with androgen receptor signaling pathway cancer, which consistent its layer localization. Then, from...