A5100396824- Hippo pathway signaling and YAP/TAZ
- Liver Disease Diagnosis and Treatment
- Wnt/β-catenin signaling in development and cancer
- Liver physiology and pathology
- Endoplasmic Reticulum Stress and Disease
- Hepatitis B Virus Studies
- Natural Compound Pharmacology Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Natural product bioactivities and synthesis
- Genomics, phytochemicals, and oxidative stress
- Lipid metabolism and biosynthesis
- Carbohydrate Chemistry and Synthesis
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Drug Transport and Resistance Mechanisms
- Hedgehog Signaling Pathway Studies
- Bioactive natural compounds
- Sesquiterpenes and Asteraceae Studies
- Bioactive Compounds and Antitumor Agents
- RNA Research and Splicing
- Liver Diseases and Immunity
- Diet, Metabolism, and Disease
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Synthesis of Organic Compounds
Northwestern Polytechnical University
2025
Ministry of Education of the People's Republic of China
2025
China Pharmaceutical University
2012-2024
State Key Laboratory of Natural Medicine
2017-2024
Shenzhen University
2022-2024
Shanghai University
2022-2023
Third Xiangya Hospital
2023
Central South University
2023
Shenzhen Sixth People's Hospital
2020-2022
E Ink (South Korea)
2022
Systematic bone loss is commonly complicated with inflammatory bowel diseases (IBDs) unclear pathogenesis and uncertain treatment. In experimental colitis mouse models established by dextran sulfate sodium IL-10 knockout induced piroxicam, mass quality are significantly decreased. Colitis mice demonstrate a lower formation rate fewer osteoblasts in femur. Bone marrow mesenchymal stem/stromal cells (BMSCs) from tend to differentiate into adipocytes rather than osteoblasts. Serum patients IBD...
Dysregulation of Hippo/YAP signaling leads to aberrant cell growth and neoplasia. Although the roles regulation were extensively studied in cancer biology recently, study systematically checking expression pattern core components this pathway at tumor tissue level remains lacking. In study, we thoroughly examined profile patient specimens both mRNA protein levels. We found that YAP1/TAZ their target genes, CRY61, CTGF, BIRC5, was remarkably amplified glioma tissues. Consistently, increased...
As it is closely associated with tumor proliferation, metastasis, and the immunosuppressive microenvironment, dysfunctional Hippo pathway has become an extremely attractive target for treating multiple cancers. However, to date, corresponding chemotherapeutic nanomedicines have not been developed. Herein, a supramolecular self-delivery nanomedicine in situ transforming capacity was tailor-constructed Hippo-pathway restoration, its inhibitory effect against growth metastasis investigated...
Spaceflight and microgravity environments have been shown to cause significant health impairments, including bone loss, immune dysfunction, hematopoietic disorders. Hematopoietic stem cells (HSCs), as progenitors of the system, are critical for continuous renewal regulation cells. Therefore, elucidating regulatory mechanisms governing HSC fate differentiation in is paramount importance. In this study, hindlimb unloading (HU) was employed mice simulate conditions. After 28 days HU, were...
Abstract To systematically analyze CT imaging features of hepatic cystic echinococcosis (CE), explore radiological-pathological correlations, and develop a diagnostic algorithm for accurate disease classification. This retrospective study included 48 pathologically confirmed cases CE from two medical centers. were analyzed by experienced radiologists, evaluating lesion characteristics including location, morphology, wall features, calcification patterns. Imaging findings correlated with...
Aberrant activation of Wnt/β-catenin signalling is critical in the progression human cancers, especially colorectal cancer (CRC). Therefore, inhibition a significant potential target for CRC therapy. Here, we identified first time that Physalin F (PF), steroid derivative isolated from Physalis angulate, acts as an antagonist signalling. In vitro, PF decreased Wnt3a-induced TOPFlash reporter activity HEK293T cells and promoted formation β-catenin destruction complex. Importantly, also...
The first examples of type B polycyclic polyprenylated acylphloroglucinols with a bicyclo[5.3.1]hendecane core, hyperberins A (1) and (2), were isolated from Hypericum beanii, together three biosynthetic congeners. Their structures established by combination NMR, electric circular dichroism (ECD), X-ray diffraction analyses. These isolates indicated divergent cationic cyclization as key steps in the biosynthesis PPAPs diverse architectures. Compounds 1 2 moderately cytotoxic exhibited...
Sarglaromatics A-E (1-5, respectively), five unprecedented naphthalene-like architecture-fused norlindenane sesquiterpene dimers, were discovered from the roots of Sarcandra glabra. The unique naphthalene core skeleton was obtained classical lindenane [4 + 2] dimers via a free-radical-mediated C11-C11' bond formation reaction and 12'-decarboxylation. highly fused octonary ring elucidated by HRMS, NMR, ECD, quantum chemical calculations, biogenetic inspiration. Compounds 1 2 showed...
Background and Aims: Nonalcoholic fatty liver disease its progressive form, nonalcoholic steatohepatitis (NASH), are rapidly becoming the top causes of hepatocellular carcinoma (HCC). Currently, there no approved therapies for treatment NASH. DEAD‐box protein 5 (DDX5) plays important roles in different cellular processes. However, precise role DDX5 NASH remains unclear. Approach Results: expression was downregulated patients with NASH, mouse models diet‐induced (high‐fat diet [HFD],...
The emergence of secondary resistance is the main failure cause epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) as a targeted therapy for non-small cell lung cancer (NSCLC). EGFR mutations NSCLC cells can markedly increase glutamine transporter (SLC1A5) expression, thereby increasing metabolism. Glutamine metabolites activate downstream signals, including mTOR, ERK1/2, STAT3, etc., which an important decreased sensitivity to EGFR-TKIs. CCK8 and Annexin V/PI assays...
Gamma-Aminobutyric Acid Type B Receptor (GABABR) plays essential roles in tumor progression.However, the function of GABABR colorectal cancer (CRC) needs further clarification.As main part GABABR, GABABR1 expression was identified significantly lower tissues than those non-tumor normal and that CRC patients with high lived longer.Further studies indicated knockdown elevated cell proliferation, migration, invasion.Furthermore, activated epithelial-mesenchymal transition (EMT)-related proteins...
Limb and CNS expressed 1 like (LIX1L) is over-expressed in several types of tumors. However, the function LIX1L glucose metabolism hepatocellular carcinoma (HCC) progression remains elusive. Here we report that human HCC tissues, which predicts unfavorable prognosis. deficiency vivo significantly attenuated liver cancer initiation mice. Functional studies indicated overexpression elevated proliferation, migratory, invasive capacities cells vitro, promoted growth metastasis vivo. knockdown...
Liver fibrosis is one of the leading causes morbidity and mortality worldwide but lacks any acceptable therapy. The transcription factor glioma-associated oncogene homologue 1 (GLI1) a potentially important therapeutic target in liver fibrosis. This study investigates anti-fibrotic activities potential mechanisms phytochemical, physalin B.Two mouse models (CCl4 challenge bile duct ligation) were used to assess antifibrotic effects B vivo. Mouse primary hepatic stellate cells (pHSCs) human...
Previously, we have reported a withanolide-type steroid, named tubocapsenolide A (TA), which shows potent anti-proliferative activity in several cancer cell lines. However, its inhibitory effect on the Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) pathway therapeutic potential osteosarcoma not been reported.In present study, aimed to investigate molecular mechanism TA osteosarcoma.The biological functions U2OS cells were investigated using colony formation,...
Acquired resistance represents a critical clinical challenge to molecular targeted therapies such as tyrosine kinase inhibitors (TKIs) treatment in hepatocellular carcinoma (HCC). Therefore, it is urgent explore new mechanisms and therapeutics that can overcome or delay resistance. Here, US Food Drug Administration (FDA)-approved pleuromutilin antibiotic identified overcomes sorafenib HCC cell lines, line-derived xenograft (CDX) hydrodynamic injection mouse models. It demonstrated lefamulin...
Hance is a vegetative food and can be used as folk beverage or soup to clear liver toxins prevent damage. However, the components effects of
Hyperzrones A (