A5101496356- Traumatic Brain Injury and Neurovascular Disturbances
- Spaceflight effects on biology
- Aquaculture disease management and microbiota
- Invertebrate Immune Response Mechanisms
- Neurosurgical Procedures and Complications
- Immune Cell Function and Interaction
- Hip and Femur Fractures
- Hematopoietic Stem Cell Transplantation
- Immunotherapy and Immune Responses
- Spinal Fractures and Fixation Techniques
- Immune cells in cancer
- Genetics, Aging, and Longevity in Model Organisms
- Glioma Diagnosis and Treatment
- Cancer Cells and Metastasis
- CNS Lymphoma Diagnosis and Treatment
- Trauma and Emergency Care Studies
- Cell Adhesion Molecules Research
- Intracranial Aneurysms: Treatment and Complications
- Microfluidic and Bio-sensing Technologies
- Erythrocyte Function and Pathophysiology
- High Altitude and Hypoxia
- Antimicrobial Peptides and Activities
- Acute Ischemic Stroke Management
- Inflammasome and immune disorders
- Bone fractures and treatments
Northwestern Polytechnical University
2020-2025
Ministry of Education of the People's Republic of China
2024-2025
The University of Texas Health Science Center at San Antonio
2024
Biomechanics Institute of Valencia
2022
Wenzhou Medical University
2012-2020
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2012-2020
University of Chinese Academy of Sciences
2015-2017
Institute of Hydrobiology
2015-2017
Chinese Academy of Sciences
2015-2017
Abstract For a virus to replicate efficiently, it must try and inhibit host IFN expression because is an important defense at early stages after viral infection. aquatic viruses, the mechanisms used escape hosts system are still unclear. In this study, we show that N protein of spring viremia carp (SVCV) inhibits zebrafish IFNφ1 production by degrading mitochondrial antiviral signaling (MAVS). First, upregulation promoter activity stimulated polyinosinic:polycytidylic acid, retinoic...
Abstract Cathelicidin antimicrobial peptides (CAMPs) represent a crucial component of the innate immune system in vertebrates. Although widely studied mammals, little is known about structure and function fish CAMPs. Further to previous findings, two more cathelicidin genes multiple transcripts from rainbow trout were identified present study. Interestingly, we found that have evolved energy-saving forms cathelicidins with total deletion characteristic cathelin-like domain. Sequence analysis...
B cells in fish were recently proven to have potent innate immune activities like macrophages. This inspired us further explore the nature of fish. Moreover, antimicrobial peptides (AMPs) are representative molecules immunity, and they can modulate functions These make an appropriate model study interactions between AMPs. Interestingly, results this revealed that IgM+ IgT+ rainbow trout could express multiple AMP genes, including four cathelicidin genes one β-defensin gene. The expression...
Spaceflight and microgravity environments have been shown to cause significant health impairments, including bone loss, immune dysfunction, hematopoietic disorders. Hematopoietic stem cells (HSCs), as progenitors of the system, are critical for continuous renewal regulation cells. Therefore, elucidating regulatory mechanisms governing HSC fate differentiation in is paramount importance. In this study, hindlimb unloading (HU) was employed mice simulate conditions. After 28 days HU, were...
Substantial controversy still exists regarding the use of surgical excision in treatment primary central nervous system lymphoma (PCNSL). This study was aimed to evaluate survival benefit PCNSL patients based on a US population. Using Surveillance, Epidemiology, and End Results (SEER) Program database, total 3,543 were identified from 2000 2014 for analysis. Surgical accessed via Kaplan-Meier multivariate Cox regression analyses. Coarsened exact matching (CEM) analysis additionally employed...
Abstract Atherosclerosis is one of the leading causes morbidity and mortality, mainly due to immune response triggered by recruitment monocytes/macrophages in artery wall. Accumulating evidence have shown that matrix stiffness oxidized low‐density lipoproteins (ox‐LDL) play important roles atherosclerosis through modulating cellular behaviors. However, whether there a synergistic effect for ox‐LDL on macrophages behavior has not been explored yet. In this study, we developed model system...
The bone marrow (BM) niches are the complex microenvironments that surround cells, providing various external stimuli to regulate a range of haematopoietic stem cell (HSC) behaviours. Recently, it has been proposed fate decision HSCs is often correlated with significantly altered biophysical signals BM niches. To thoroughly elucidate effect mechanical on fates, we constructed 2D and 3D culture hydrogels using polyacrylamide replicate properties heterogeneous sub-niches, including inherent...
Physical signals provided by the extracellular matrix (ECM) are key microenvironmental parameters for fate decision of hematopoietic stem and progenitor cells (HSPC) in bone marrow. Insights into cell-ECM interactions critical advancing HSC-based tissue engineering. Herein, we employed collagen hydrogels collagen-alginate defined stiffness to study behaviors (HPCs). Three-dimensional (3D) with a 45 Pa were found promote HPC maintenance colony formation monocyte/macrophage progenitors. Using...
Gender may be related with the outcome of patients acute traumatic brain injury (TBI). We explored effect gender on 7145 TBI. There was no statistical difference between male and female sex in causes trauma, age, Glasgow Coma Scale score, computed tomgraphy findings, surgical management. The mortality TBI males females 7.48% 7.22%, respectively, corresponding unfavorable outcomes 16.05% 17.23%, respectively (p > 0.05 both cases). 1626 severe 19.68% 20.72%, 46.96% 48.85%, Our data suggest...
Although technically regarded as a simple procedure, titanium mesh cranioplasty could lead to various surgical complications, including postoperative implant exposure. However, there is little data available on the occurrence and risk factors of this complication in pediatric population. Two male patients, one 12-year-old 7-year-old, had decompressive craniectomy after traumatic brain injuries subsequent with mesh. both patients skin defects developed gradually at scalp adjacent incisions,...
Posterior fossa epidural hematomas (PFEDH) are uncommon in children but usually require timely surgical intervention due to the risk of life-threatening brainstem compression. We attempt make procedure less invasive by treating selected pediatric patients with trephination mini-craniectomy.We retrospectively reviewed clinical courses, radiological findings, procedures, and prognoses who were treated our departments for traumatic PFEDH from January 2010 2015.During this period, a total 17...