A5060503737- Cancer-related molecular mechanisms research
- Angiogenesis and VEGF in Cancer
- Lymphatic System and Diseases
- Ferroptosis and cancer prognosis
- Prostate Cancer Treatment and Research
- Renal cell carcinoma treatment
- interferon and immune responses
- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- PARP inhibition in cancer therapy
- Ubiquitin and proteasome pathways
- Thyroid Cancer Diagnosis and Treatment
- Ocular Oncology and Treatments
- DNA Repair Mechanisms
- Mycotoxins in Agriculture and Food
- Infectious Diseases and Mycology
- MicroRNA in disease regulation
- Drug-Induced Ocular Toxicity
- Colorectal Cancer Surgical Treatments
- Circular RNAs in diseases
- Autophagy in Disease and Therapy
- Signaling Pathways in Disease
- Calpain Protease Function and Regulation
- Graphene and Nanomaterials Applications
- FOXO transcription factor regulation
Jiangsu Province Hospital
2017-2023
Nanjing Medical University
2017-2023
Suzhou Vocational Health College
2022
Institute of Reproductive Medicine
2020
North China Institute of Science and Technology
2020
State Key Laboratory of Reproductive Medicine
2020
First Affiliated Hospital of Jinan University
2015-2017
Neuroendocrine prostate cancer (NEPC), the most lethal subtype of castration-resistant (PCa), may evolve from neuroendocrine differentiation (NED) PCa cells. However, molecular mechanism that triggers NED is unknown. Trigred motif 36 (TRIM36), a member TRIM protein family, exhibits oncogenic or anti-oncogenic roles in various cancers. We have previously reported TRIM36 highly expressed to inhibit invasion and proliferation PCa. In present study, we first found was lowly NEPC its...
The calpain 2 (CAPN2) is upregulated in various malignant carcinomas. Previous studies have reported that CAPN2 functioned as an oncogenic factor human cancers. However, its clinical role and potential effects on cell metastasis proliferation renal carcinoma (RCC) remain unknown. In this study, we evaluated the mRNA protein levels of RCC specimens, matched normal lines using quantitative Real-time PCR (RT-PCR) western blot. Immunohistochemistry 74 tissues a tissue microarrays (TMAs) kidney...
// Jundong Zhu 1, * , Chao Liang Yibo Hua Chenkui Miao 1 Jianzhong Zhang Aiming Xu Kai Zhao Shouyong Liu Ye Tian Huiyu Dong Pu Li Shifeng Su Qin and Zengjun Wang Department of Urology, The First Affiliated Hospital Nanjing Medical University, Nanjing, China These authors contributed equally to this work Correspondence to: Wang, email: zengjunwang@njmu.edu.cn Qin, 13776678978@163.com Keywords: CD82/KAI1, tetraspanin, migration/invasion, TGF-β1/Smad signaling, renal cell carcinoma Received:...
// Kang Liu 1, * , Xiao Li 2, Jie Wang Yichun 1 Huiyu Dong Department of Urology, The First Affiliated Hospital Nanjing Medical University, Nanjing, China 2 Cancer Jiangsu Province These authors contributed equally to this work Correspondence to: Li, email: lijie_urology@163.com Keywords: genetic variants, RhoA/ROCK1 pathway, prostate cancer, prognosis, biochemical recurrence Received: July 27, 2016 Accepted: January 03, 2017 Published: February 08, ABSTRACT contribution variants in RhoA and...
In this study, we investigated the in vitro antifungal effects of itraconazole/voriconazole (ITR/VRC) alone and combination with tetrandrine (TET) against 23 clinical isolates A. fumigatus using a chequerboard microdilution method. The dynamic TET ITR/VRC were assessed vivo time-kill curves following systemic infection mice fumigatus. After treatment, efflux pump activity was determined by rhodamine 6G (R6G). When ITR combined TET, MICs reduced from 0.125-32 to 0.0625-2 μg ml(-1), 256-512...
Solitary fibrous tumor (SFT) is a rare fibroblast stroma involving the mediastinum and pleura. We herein describe an SFT of bladder which extremely review 29 similar cases in last decades. present case 52-year-old male patient who suffered from urinary urgency frequency for 12 months. Non-contrast computed tomography (CT) showed slightly high density calcified mass with 70 mm × 61 diameter. Contrast-enhanced CT demonstrated was enhanced. Cystoscopy revealed huge flat surface....
The enhanced recovery after surgery (ERAS) program is focused on improving surgical outcomes and enhancing the patient experience before, during surgery. We performed this study to evaluate effect of ERAS in perioperative period laparoscopic nephron sparing (LNSS).A retrospective analysis 287 consecutive patients with localized renal cell carcinoma (RCC) who underwent LNSS from December 2015 June 2017 was conducted. Our design included two cohorts. Patients conventional care one group...
Recent studies revealed the relationship among homologous recombination repair (HRR), androgen receptor (AR), and poly(adenosine diphosphate-ribose) polymerase (PARP); however, synergy between anti-androgen enzalutamide (ENZ) PARP inhibitor olaparib (OLA) remains unclear. Here, we showed that synergistic effect of ENZ OLA significantly reduced proliferation induced apoptosis in AR-positive prostate cancer cell lines. Next-generation sequencing followed by Gene Ontology Kyoto Encyclopedia...
Ocular toxicity is an uncommon complication of cytotoxic chemotherapy. Bilateral blindness with secondary retinitis pigmentosa (RP) following docetaxel and platinum combination chemotherapy at the recommended dose extremely rare. The present study reports a case advanced small-cell carcinoma (SCC) endometrium in patient diabetes mellitus type 2. suffered from RP sharp decline vision after fourth course postoperative Unfortunately, developed bilateral another reduced dose. No tumor recurrence...
Studies over the past decade have shown that long non-coding RNAs (lncRNAs) play an essential role in tumorigenesis and progression of kidney renal clear cell carcinoma (KIRC). Meanwhile, autophagy has been demonstrated to regulate KIRC pathogenesis targeting therapy resistance. However, prognostic value autophagy-related lncRNAs patients not reported before.
Abstract Background Recent studies indicate that the correlation in expression level of CD9 and prognosis differs from tumor types. This meta-analysis was performed to illustrate predictive value CD9. Methods analysis included 13 involving a total 1231 patients. We used PubMed, Cochrane Library, Web Science Embase for comprehensive literature search manual related bibliography. To probe into relationships between patient prognosis, pooled hazard ratios (HRs) with 95% confidence intervals...
Abstract BackgroundStudies over the past decade have shown that long non-coding RNAs (lncRNAs) play an essential role in tumorigenesis and progression of kidney renal clear cell carcinoma (KIRC). Meanwhile, autophagy has been demonstrated to regulate KIRC pathogenesis targeting therapy resistance. However, prognostic value autophagy-related lncRNAs patients not reported before.MethodsIn this study, we obtained transcriptome data 611 cases from TCGA database 258 mRNAs HADb identify by...
Abstract Background: Studies over the past decade have shown that long non-coding RNAs (lncRNAs) play an essential role in tumorigenesis and progression of kidney renal clear cell carcinoma (KIRC). Meanwhile, autophagy has been demonstrated to regulate KIRC pathogenesis targeting therapy resistance. However, prognostic value autophagy-related lncRNAs patients not reported before. Methods: In this study, we obtained transcriptome data 611 cases from TCGA database 258 mRNAs HADb identify by...
Abstract Neuroendocrine prostate cancer (NEPC) arises from transdifferentiated adenocarcinoma following androgen deprivation therapy (ADT), which belongs to the most lethal subtype of castration-resistant (PCa). ADT paradoxically promoted incidence NEPC, with a mechanism awaiting be clarified. Trigred motif 36 (TRIM36), member trim protein family, participates in variety cellular processes. Our previous experimental results have confirmed that TRIM36 was highly expressed PCa and inhibited...