A5100384888- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Cardiac, Anesthesia and Surgical Outcomes
- Frailty in Older Adults
- Caveolin-1 and cellular processes
- Colorectal Cancer Treatments and Studies
- Helicobacter pylori-related gastroenterology studies
- COVID-19 and healthcare impacts
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
- Gas Dynamics and Kinetic Theory
- Liver physiology and pathology
- Microtubule and mitosis dynamics
- Physics and Engineering Research Articles
- Dental Research and COVID-19
- Kruppel-like factors research
- Liver Disease Diagnosis and Treatment
- Infection Control and Ventilation
- Drug Transport and Resistance Mechanisms
- Genetic factors in colorectal cancer
- Hemoglobin structure and function
Harbin Medical University
2024
First Affiliated Hospital of Harbin Medical University
2024
Fourth Hospital of Hebei Medical University
2019-2023
Huashan Hospital
2017-2023
Hebei Medical University
2019-2023
Fudan University
2004-2023
Second Affiliated Hospital of Zhejiang University
2022-2023
Tianjin Medical University General Hospital
2023
Hospital of Hebei Province
2021
University of Cincinnati Medical Center
2021
To ascertain if preoperative short-term radiotherapy followed by chemotherapy is not inferior to a standard schedule of long-term chemoradiotherapy in patients with locally advanced rectal cancer.Patients distal or middle-third, clinical primary tumor stage 3-4 and/or regional lymph node-positive cancer were randomly assigned (1:1) (25 Gy five fractions over 1 week) four cycles (total neoadjuvant therapy [TNT]) (50 25 5 weeks, concurrently capecitabine [chemoradiotherapy; CRT]). Total...
Background Stomach cancer is a significant health problem in many countries. But healthcare needs of adolescents and young adults (AYAs) stomach patients have been historically neglected. An accurate appraisal the burden AYA crucial to formulating effective preventive strategies. In this study, we report most recent estimates concerning socio-demographic index (SDI) 204 countries territories between 1990 2019. Methods Estimates from Global Burden Disease study 2019 were used analyze...
3510 Background: It’s presented the results of a phase III trial short-term radiotherapy (SCRT) combined with chemotherapy versus long-term chemoradiotherapy (LCRT) in patients locally advanced rectal cancer (LARC). Methods: Patients distal or middle third, T3-T4 and/or N+ adenocarcinomas diagnosed by MRI, were randomly assigned to experimental group control group. In group, received SCRT (25 Gy / 5 fractions days), followed four courses CAPOX. LCRT (50 25 35 days concurrent capecitabine)....
Background The RhoA/ROCK pathway and Caveolin-1 (Cav-1) participate in the process of tumorigenesis numerous types cancer. Up-regulation Cav-1 expression is considered to be associated with development progression clear cell renal carcinoma (ccRCC). We investigated association between genetic variations risk ccRCC Chinese population. Methods Between May 2004 March 2014, a total 1,248 cases 1,440 cancer-free controls were enrolled this hospital-based case-control study. Nine SNPs genotyped...
Pleckstrin-2 (PLEK2) is a crucial mediator of cytoskeletal reorganization. However, the potential roles PLEK2 in gastric cancer are still unknown. expression was examined by western blotting and real-time PCR. Survival analysis utilized to test clinical impacts levels patients. In vitro vivo studies were used estimate played modulating proliferation, self-renewal, tumourigenicity. Bioinformatics approaches monitor effect on epithelial-mesenchymal transition (EMT) signalling pathways....
Purpose To investigate the clinical factors affecting pathological complete response (pCR) after neoadjuvant chemoradiotherapy (nCRT) in locally advanced rectal cancer (LARC). Methods Clinical data of 124 LARC patients treated with nCRT and surgery fourth Hospital Hebei Medical University from 2014 to 2019 were retrospectively analyzed. In this study, univariate analysis logistic dichotomous multivariate regression used study pCR, receiver operator characteristic curve (ROC) was further...
<h3>Importance</h3> Several studies have explored the efficacy and toxic effects of concurrent 5-fluorouracil (5-FU)– or capecitabine-based chemoradiotherapy (CRT) with without oxaliplatin in neoadjuvant setting. Addition to 5-FU capecitabine elicited similar outcomes but significantly increased effects; however, there is a need for randomized clinical trials comparing 2 CRT regimens patients receiving adjuvant <h3>Objective</h3> To explore combined postoperative radiotherapy (RT)...
Anastomotic leakage is a serious complication after colorectal cancer surgery, which affects the quality of life and prognosis. This study aims to create novel nomogram predict risk anastomotic for patients with based on preoperative inflammatory-nutritional index abdominal aorta calcium index.292 at Tianjin Medical University General Hospital (Tianjin, China) from January 2018 October 2021 who underwent surgery primary anastomosis were retrospectively reviewed. A was constructed results...
Preoperative concurrent chemoradiotherapy (CCRT) as the standard treatment for locally advanced rectal cancer (LARC) has been widely used in clinic. Its efficiency influences prognosis and selection of subsequent treatment. The current criteria evaluating patients with extremely sensitive preoperative CCRT include clinical complete remission response (cCR) pathological (pCR), but those cCR may not necessarily achieve pCR, pCR can be confirmed only after surgery. Some scholars believe that...
Background: Multidrug-resistance protein (MRP) 2 is a key membrane transporter that expressed on hepatocytes and regulated by nuclear factor kappa B (NF-κB). Interestingly, endoplasmic reticulum (ER) stress closely associated with liver injury the activation of NF-κB signaling. Objective: Here, we investigated impact ER MRP2 expression functional involvement in acute injury. Methods: stress, expression, hepatocyte were analyzed carbon tetrachloride (CCl4)-induced mouse model thapsigargin...
e15006 Background: To present an interim analysis of a phase III trial comparing short-course radiotherapy followed by chemotherapy with long-course chemoradiotherapy in locally advanced rectal cancer. Methods: Patients distal or middle third, MRI diagnosed cT3-T4 N+ adenocarcinomas were randomized to either 5 x Gy and 4 courses CAPOX (experimental group) 50 delivered 25 fractions given concurrently capecitabine (control group). Total mesorectal excision (TME) both groups was performed 6-8...
Background Gastric cancer (GC) is a significant public health concern in the USA, and its burden on rise. Methods This study utilized latest data from Global Burden of Disease (GBD) study. We provided descriptive statistics incidence, prevalence, mortality, disability-adjusted life years (DALYs), age-standardized rates (ASRs) GC across USA states. By calculating percentage changes average annual (AAPC), along with conducting age-period-cohort analysis, we assessed trends GC. Decomposition...
We propose a modification to the reconstruction method of natural orifice specimen extraction surgery (NOSES) during laparoscopic anterior resection (LAR) for rectal cancer (RC) and evaluated its feasibility short-term safety by comparing surgical postoperative outcomes with those conventional LAR. Twenty patients RC underwent "double-purse" NOSES-LAR from October 2017 June 2018. Data clinicopathological characteristics, outcomes, follow-up findings in cases were collected retrospectively...
e15688 Background: Fit elderly patients evaluated by comprehensive geriatric assessment (CGA) is recommended to receive preoperative concurrent chemoradiotherapy (preCRT) for intermediate or locally advanced rectal cancer. However, this strategy has never been prospectively investigated. Methods: Trial design: single arm, multicenter, phase II trial (Registered in clinicaltrials.gov with NCT02992886). Brief inclusion criteria: were aged 70 years above adenocarcinoma of clinical stage II/III,...
The aim of this study is to investigate the influencing factors associated with no/low response preoperative concurrent chemoradiotherapy (CCRT) for locally advanced rectal cancer (LARC) patients. A total 79 patients were included in prospective study. Fifteen that might affect resistance CCRT logistic regression analysis, these include general clinical data patients, expression status tumor stem cell marker CD44v6 and volumetric imaging parameters primary lesions. We found was positively...
Cadaveric simulation study.The novel coronavirus (COVID-19), which can be transmitted via aerosolized viral particles, has directed focus on protection of healthcare workers during procedures involving the upper aerodigestive tract, including maxillofacial trauma repair. This study evaluates particle generation at different distances from open reduction and internal fixation (ORIF) injuries in intraoperative setting to reduce risk contracting airborne diseases such as COVID-19.Two cadaveric...
Abstract Background and purpose: The purpose of this study was to evaluate the safety efficacy preoperative concurrent chemoradiotherapy (preCRT) for locally advanced rectal cancer in older people who were classified as “fit” by comprehensive geriatric assessment (CGA). Methods: A single-arm, multicenter, phase II trial designed. Patients eligible if they aged 70 years or above met standards (SIOG1) evaluated CGA risk category. primary endpoint 2-year disease-free survival (DFS). scheduled...
Background Alpha-fetoprotein (AFP)–producing gastric cancer is a distinct type of with high incidence liver metastasis. c-Met considered to play an important role in metastasis cancer. Objective The purpose this study was compare the expression AFP-producing and cancers not producing AFP. Methods We evaluated 23 patients (AFP+) 18 common (AFP–) were for using immunohistochemical analysis. Results 2 groups same (P &gt; 0.05), but AFP+ group had higher strong positive rate than AFP–...