A5100449376- Breast Cancer Treatment Studies
- Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Colorectal Cancer Surgical Treatments
- Metastasis and carcinoma case studies
- Breast Lesions and Carcinomas
- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- RNA modifications and cancer
- Advanced Radiotherapy Techniques
- Colorectal Cancer Screening and Detection
- Cancer, Hypoxia, and Metabolism
- Gastrointestinal Tumor Research and Treatment
- Breast Implant and Reconstruction
- Circular RNAs in diseases
- Cancer Research and Treatments
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Digital Radiography and Breast Imaging
- Proteoglycans and glycosaminoglycans research
- Bladder and Urothelial Cancer Treatments
- Esophageal Cancer Research and Treatment
- Management of metastatic bone disease
- Lung Cancer Diagnosis and Treatment
Sun Yat-sen University
2022-2025
Sun Yat-sen University Cancer Center
2022-2025
State Key Laboratory of Oncology in South China
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2024
Hebei Medical University
2018-2024
Fourth Hospital of Hebei Medical University
2018-2024
Shaoxing City Women and Children Hospital
2023
Central South University
2021
Huazhong University of Science and Technology
2021
Union Hospital
2021
BackgroundMultiple approaches based on cell-free DNA (cfDNA) have been applied to detect minimal residual disease (MRD) and predict prognosis or recurrence. However, a comparison of the used in different cohorts studies is difficult. We aimed compare multiple for MRD analysis after neoadjuvant therapy (NAT) patients with locally advanced rectal cancer (LARC).MethodsSixty LARC from multicentre, phase II/III randomized trial were included, tissue blood samples collected. For each cfDNA sample,...
Abstract Background: Hyaluronic acid (HA) may be a novel prognostic biomarker of breast cancer. However, the available evidence is controversial. Therefore, we performed meta-analysis to determine role HA in Methods: The data were extracted from seven articles by searching databases PubMed, EMBASE, Web Science, Chinese National Knowledge Infrastructure and Wanfang for In reference survival outcomes, pooled hazard ratios (HRs) calculated given 95% confidence interval (CI). Results: A total...
Background: Chemotherapy combined with immunotherapy (CT-IO) has become the first-line treatment for de novo metastatic nasopharyngeal carcinoma (dmNPC). Locoregional radiotherapy (LRRT) following chemotherapy been shown to significantly improve survival outcomes in patients dmNPC. However, it remains unclear whether LRRT provides additional benefits context of CT-IO. Furthermore, there is no consensus on how identify optimal patient population after Methods: This study included dmNPC who...
Objectives: Although different methods have been established to detect epidermal growth factor receptor (EGFR) T790M mutation in circulating tumor DNA (ctDNA), a wide range of diagnostic accuracy values were reported previous studies. The aim this meta-analysis was provide pooled measures for droplet digital PCR (ddPCR) the diagnosis EGFR based on ctDNA. Materials and methods: A systematic review carried out resources from Pubmed, Web Science, Embase Cochrane Library up October 11, 2017....
To explore the mechanism of effect baicalein on radioresistance esophageal cancer, and to provide ideas for treatment patients with poor radiotherapy cancer. The glycolytic rate assay kit was used detect changes in metabolism cancer cells after baicalein, mass spectrometry whether could affect level glycolysis-related metabolites cells. binding target protein simulated by molecular docking technique, expression detected Western Blot, cell cycle were flow cytometry. Radiation combined...
Abstract Radiotherapy plays a crucial role in combined treatment modality local advanced rectal cancer (LARC). While neoadjuvant chemoradiotherapy responses were variable LARC patients, so, it is important to identify genes that closely associated with short‐term and long‐term radiotherapy. In this study, we profiled long noncoding RNAs (lncRNAs) messenger (mRNAs) expression values of patients different downstaging depth score based on Agilent Arraystar Human LncRNA V3.0 Array(Agilent, CA)....
The long non-coding RNA X-inactive specific transcript (XIST) plays a crucial role in transcriptional silencing of the X chromosome. Zinc finger E-box-binding homeobox 1 (ZEB1) is transcription factor involved epithelial-mesenchymal transition (EMT) regulation. This study aimed to investigate impact XIST on esophageal squamous cell carcinoma (ESCC) progression and its underlying mechanism involving miR-34a/ZEB1/E-cadherin/EMT pathway. ZEB1 expression were analyzed using quantitative PCR...
Abstract Background Silica exposure underlies the development of silicosis, one most serious occupational hazards worldwide. We aimed to explore interaction silica-induced epithelial–mesenchymal transition (EMT)-related transcripts with cellular metabolism regulated by p53. Methods knocked out p53 using CRISPR/Cas9 in human bronchial epithelial (HBE) cell line. The transcriptomic and metabolomic analyses integrative omics were conducted microarrays, GC–MS, MetaboAnalyst, respectively....
Abstract Background Peri-operative chemo-radiotherapyplayed important rolein locally advanced gastric cancer. Whether preoperative strategy can improve the long-term prognosis compared with postoperative treatment is unclear. The study purpose to compare oncologic outcomes in cancer patients treated chemo-radiotherapy (pre-CRT) and (post-CRT). Methods From January 2009 April 2019, 222 from 2 centers stage T3/4 and/or N positive who received pre-CRT post-CRT were included. After propensity...
Objective We evaluated and compared the efficacy safety of neoadjuvant chemoradiotherapy (NACRT) versus chemotherapy (NACT) for locally advanced gastric cancer (LAGC) in a single-center randomized phase II trial. Methods Patients with LAGC were enrolled received either NACT or NACRT, followed by gastrectomy adjuvant chemotherapy. The primary endpoint was an R0 resection rate. Results 75 patients: 75.7% (NACT, 28/37 patients) 76.3% (NACRT, 29/38 underwent surgery; rates 73.0% (27/37) 73.7%...
BackgroundThe phase 3 NCT00793962 trial demonstrated that postmastectomy hypofractionated radiation therapy (HFRT) was noninferior to conventional fractionated (CFRT) in patients with high-risk breast cancer. This study assessed the cost-effectiveness of HFRT vs CFRT based on trial.MethodsA Markov model adopted synthesize medical costs and health benefits cancer data from trial. Main outcomes were discounted lifetime costs, quality-adjusted life-years (QALYs), incremental ratio (ICER). We...
AIM:To analyze the clinical features, management, and outcome of treatment patients with primary intestinal colonic non-Hodgkin's lymphoma (PICL). METHODS:A retrospective study was performed in 37 early-stage PICL who were treated our hospital from 1958 to 1998.Their assessed.Prognostic factors for survival analyzed by univariate analysis using Kaplan-Meier product-limit method log-rank test. RESULTS:Twenty-five presented Ann Arbor stage I 12 II PICL.Thirty-five underwent surgery (including...
To compare dosimetric parameters of intensity-modulated radiotherapy (IMRT), volumetric-modulated arc therapy (VMAT) and tomotherapy (TOMO) in the adjuvant treatment gastroesophageal junction (GEJ)/stomach cancer. The planning goal was to maintain high target coverage while keeping dose bowel bone marrow (BM) as low possible.After curative surgery, 16 patients with GEJ/stomach cancer were re-planned by coplanar IMRT (five fixed beam), VMAT (double-arc), TOMO. volume (PTV) 45 Gy 25 fractions....
Prognosis of patients with locally advanced rectal cancer (LARC) but achieving ypT1-2N0 stage after neoadjuvant concurrent chemo-radiotherapy (CRT) has been shown to be favorable. This study aims determine whether the long-term outcome cases can comparable that pT1-2N0 cohort received definitive surgery for early disease.From January 2008 December 2013, 449 consecutive were treated and their maintained in a database. Patients LARC underwent total mesorectal excision (TME) at 4-8 weeks...
Objective: To analyze the outcomes of clinical T1-3N1M0 breast cancer patients with pathological negative axillary lymph nodes (ypN0) after neoadjuvant chemotherapy (NAC) and mastectomy, investigate role postmastectomy radiotherapy (PMRT). Methods: A total 185 treated between 1999 2013 were retrospectively reviewed. All NAC achieved ypN0. Of them, 89 received additional PMRT 96 did not. 101 had stage Ⅱ disease. 84 Ⅲ The rates locoregional recurrence (LRR), distant metastasis (DM),...
Previous studies have reported that neoadjuvant chemoradiotherapy can downstage the advanced gastric cancer. However, no are available on application of hypo-radiotherapy to radiotherapy. This study sought assess maximum tolerated dose (MTD) and dose-limited toxicity (DLT) hypo-fractionated for local cancer.Patients with cT3-4 and/or lymph node-positive locally cancer or Siewert II/III esophagogastric junction adenocarcinoma were enrolled. Preoperative chemoradiation was followed by 3 cycles...
<h3>Importance</h3> Several studies have explored the efficacy and toxic effects of concurrent 5-fluorouracil (5-FU)– or capecitabine-based chemoradiotherapy (CRT) with without oxaliplatin in neoadjuvant setting. Addition to 5-FU capecitabine elicited similar outcomes but significantly increased effects; however, there is a need for randomized clinical trials comparing 2 CRT regimens patients receiving adjuvant <h3>Objective</h3> To explore combined postoperative radiotherapy (RT)...