A5100446097- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Anorectal Disease Treatments and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Appendicitis Diagnosis and Management
- Minimally Invasive Surgical Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Esophageal and GI Pathology
- Helicobacter pylori-related gastroenterology studies
- Bladder and Urothelial Cancer Treatments
- Gastrointestinal Tumor Research and Treatment
- Glycosylation and Glycoproteins Research
- Pelvic and Acetabular Injuries
- Hedgehog Signaling Pathway Studies
- Bariatric Surgery and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Venous Thromboembolism Diagnosis and Management
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Galectins and Cancer Biology
- Global Health and Surgery
Peking University
2021-2024
Peking University Third Hospital
2021-2024
Shanghai Cancer Institute
2023
Second Military Medical University
2002-2023
Changhai Hospital
2009-2023
Peking University Cancer Hospital
2023
Hainan Medical University
2020-2023
Hainan General Hospital
2020-2023
National Clinical Research Center for Digestive Diseases
2022
Capital Medical University
2022
In advanced and metastatic stages of colorectal cancer (CRC), reduced sensitivity to conventional strategies is still a major obstacle successful treatments. Decorin an important regulator in the development progression various cancers. To examine if CRC patients have altered decorin levels, expression its target genes, Met vascular endothelial growth factor A (VEGFA), were analyzed their tumors. Compared normal tissues, was patients' tumors, while there increased VEGFA levels. develop novel...
Rationale Intravenous thrombolysis combined with mechanical thrombectomy (MT) has been proven safe and clinical effective in patients acute ischemic stroke of anterior circulation large vessel occlusion. However, despite reperfusion, a considerable proportion do not recover. Incidence symptomatic intracerebral hemorrhage was similar between treated the combination intravenous MT, as compared to alone, suggesting that this complication should be attributed pre-treatment thrombolysis....
Precise preoperative evaluation of lymph node metastasis (LNM) is crucial for ensuring effective treatment rectal cancer (RC). This research aims to develop a clinical-radiomics nomogram based on deep learning techniques, magnetic resonance imaging (MRI) and clinical characteristics, enabling the accurate prediction LNM in RC.Between January 2017 May 2023, total 519 cases confirmed by pathological examination were retrospectively recruited from two tertiary hospitals. A 253 consecutive...
e15603 Background: Neoadjuvant chemoradiotherapy (nCRT) not only could bring tumor downsizing and downstaging but also achieve clinical complete response (cCR) or pathological (pCR). Although immunotherapy benefits MSI-H/dMMR rectal cancer patients, little is observed in MSS/pMMR patients. Several trials including VOLTAGE trial demonstrated that a combination of PD-1 inhibitor nCRT result promising even But the elucidation regarding organ preservation after treatment lacking. Watch Wait...
Objective: Colorectal cancer (CRC) remains a major cause of cancer-related death worldwide. Proteasome 26S subunit ATPase 2 (PSMC2) plays vital roles in regulating cell cycle and transcription has been confirmed to be gene potentially associated with some human tumors. However, the expression correlation molecular mechanism PSMC2 CRC are still unclear. This study aimed investigate role malignant behaviors CRC. Methods: The high protein levels samples were identified by tissue microarray...
Purpose: The aim of this study is to visualize and analyze the research hot pots in radiation therapy for rectal cancer provide researchers with a clear visual reference subsequent studies. Methods: literature scientometric analysis about "external beam (EBRT) cancer" was made through WoSCC (2010 2019). And data visualized analyzed by Microsoft Office Excel (2019) CiteSpace (V. 5.7.R1). Results: 4,263 relevant articles were downloaded. number published per year has been increasing...
It is still controversial whether laparoscopy-assisted colectomy (LAC) suitable for patients with stage T4 colon cancer. This study aimed to compare the short- and long-term outcomes of LAC open (OC) pathologic Data eligible cancer in our institution from March 2004 September 2014 were retrospectively reviewed. The followed up 2016. Propensity score matching was performed control bias. Two hundred forty two selected by propensity matching, 121 group OC group. Mean operating time rate...
Abstract Background Placement of a self-expanding metal stent (SEMS) in patients presenting with an acute colorectal obstruction (ACO) may obviate emergency surgery (ES), potentially effectively palliating incurable tumors, acting as bridge to (BTS) operable or tumors and achieving effective decompression other ACO. We present our experience SEMS insertion by surgeons without fluoroscopic monitoring for ACO especially malignant (AMCO) nearly 14-year period (2007–2020). Aim To explore the...
<h3>Importance</h3> Several studies have explored the efficacy and toxic effects of concurrent 5-fluorouracil (5-FU)– or capecitabine-based chemoradiotherapy (CRT) with without oxaliplatin in neoadjuvant setting. Addition to 5-FU capecitabine elicited similar outcomes but significantly increased effects; however, there is a need for randomized clinical trials comparing 2 CRT regimens patients receiving adjuvant <h3>Objective</h3> To explore combined postoperative radiotherapy (RT)...
Over the last 2 decades, patients with low rectal cancer have had better outcomes from improvements in surgical techniques sphincter preservation. We aimed to quantify trends sphincter-preserving surgeries for over 20 years a top tertiary hospital China. Between 1999 and 2021, cohort of primary malignant tumor ≤5cm anal verge who received elective at Changhai Hospital, Shanghai, China, was identified. Data were extracted electronic medical records. A Joinpoint Regression Model used analyze...
Background: With the elimination of schistosomiasis in China, its role pathogenesis colorectal cancer (CRC) has decreased. However, trends, clinicopathological features, surgical treatment patterns, and prognosis schistosomiasis-associated CRC (SACRC) versus non-schistosomiasis-associated (NSACRC) China remain unclear. Materials methods: The percentage trend SACRC patients was analyzed using data retrieved from Pathology Registry Changhai Hospital (2001–2021). Clinicopathological...
Single-incision plus one-port laparoscopic surgery (SILS + 1) has been demonstrated to be minimally invasive while possessing better cosmesis and less pain compared with conventional (CLS). However, SILS 1 as an alternative CLS for colorectal cancer is still controversial.A total of 1071 patients who underwent curative colon between 2015 2018 were included. Of these patients, 258 cases 516 analyzed using propensity score matching. The baseline characteristics, surgical outcomes, pathologic...
Several studies have been conducted on the effects and toxicity of adding oxaliplatin to fluorouracil-based or capecitabine-based chemoradiotherapy (CRT) regimens as significantly increasing toxic response without benefit survival. In this study, we further explored role these two postoperative CRT in patients with pathological stage N2 rectal cancer. This study was a subgroup analysis randomized clinical trial. A total 180 cancer were eligible, 85 received capecitabine radiotherapy (RT), 95...
It is well known that neoadjuvant radiotherapy could reduce local recurrence followed by surgical resection. However, evidence about oncologic efficacy of and survival benefit adjuvant chemotherapy after still lacking.This retrospective propensity score-matched cohort study identified patients with pathologically confirmed rectal cancer receiving surgery curative intent from the Surveillance, Epidemiology, End Results database 2004 through 2014. Overall was compared using stratified log-rank...
The aim of this study was to investigate whether clinical and blood parameters can be used for predicting pathological complete response (pCR) neoadjuvant chemoradiotherapy (nCRT) in patients with locally advanced rectal cancer (LARC). We retrospectively enrolled 226 LARC [allocated a 7:3 ratio training (n = 158) or validation 68) cohort] who received nCRT before radical surgery. Backward stepwise logistic regression performed identify associated achieving pCR. Models based on (CP), (BP),...
Metabolic changes may occur following gastric surgery, which has been reported to contribute bone loss, osteoporosis and even fracture. However, the evidence regarding relationship between surgery for benign malignant conditions risk of fracture is controversial. This study was conducted with aim evaluate whether associated a high fracture.Major electronic databases were searched from inception through October 2021 population-based cohort studies investigating associations (including...