A5101884897- Acute Kidney Injury Research
- Building Energy and Comfort Optimization
- Cardiac, Anesthesia and Surgical Outcomes
- Urban Transport and Accessibility
- Eicosanoids and Hypertension Pharmacology
- Regional Development and Environment
- Human-Automation Interaction and Safety
- Cardiac Arrest and Resuscitation
- Chronic Kidney Disease and Diabetes
- Urban Heat Island Mitigation
- Cancer, Lipids, and Metabolism
- Noise Effects and Management
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- Hormonal Regulation and Hypertension
- Molecular Biology Techniques and Applications
- Parasites and Host Interactions
- Diet, Metabolism, and Disease
- Health and Wellbeing Research
- Inhalation and Respiratory Drug Delivery
- Cardiovascular Function and Risk Factors
- COVID-19 Pandemic Impacts
- Heart Failure Treatment and Management
- Cardiac Structural Anomalies and Repair
Huanghe Science and Technology College
2025
Fudan University
2025
Pudong Medical Center
2025
Gansu Provincial Hospital
2024
Zhongji Test Equipment (China)
2022-2024
Wuhan Institute of Technology
2011-2024
China Coal Research Institute (China)
2024
China Coal Technology and Engineering Group Corp (China)
2024
China University of Mining and Technology
2024
Wuhan University of Technology
2022-2024
Wuhan encountered a serious attack in the first round of coronavirus disease 2019 (COVID-19) pandemic, which has resulted public health social impact, including mental health. Based on Weibo help data, we inferred spatial distribution pattern epidemic situation and its impacts. Seven urban factors, i.e., growth, general hospital, commercial facilities, subway station, land-use mixture, aging ratio, road density, were selected for validation with ordinary linear model, former six factors...
Cross-domain EEG signals offer valuable insights into the cortical neuron activity patterns and functional dynamics of central nervous system (CNS). Within framework biomechanics, has emerged as a critical tool to investigate interplay between neural control physical performance. This study explores complexity parameters in specific brain regions 24 elite athletes under three distinct states: Rest, unloaded exercise, loaded exercise. By integrating biomechanical electrophysiological...
Background XKH001 is a recombinant humanized IgG1 monoclonal antibody against IL-25 for the treatment of type 2 inflammatory diseases. This study aimed to evaluate tolerability, pharmacokinetics, and pharmacodynamics in humans first time.
In recent years, the revival of ancestral halls has been rapidly gaining momentum across various regions in China. This paper takes eastern region Hubei Province as a case study and, based on extensive fieldwork, investigates main reasons behind accelerated contemporary China and social issues concealed this phenomenon. The key identified include: (1) serious tendency for excessive comparison construction negative impact values; (2) deep penetration grassroots administrative power into...
The current diversification of residents' travel patterns suggests a potential correlation between obesity issues and modes. In this study, we selected 93 streets in the central urban area Wuhan considered walking, cycling, public transportation travel, car as research variables. body mass index (BMI) was utilized an indicator overweight levels. Both Ordinary Least Squares (OLS) Geographically Weighted Regression (GWR) models were employed to statistically examine impact these four modes on...
Abstract Background Amyloid precursor‐like protein 1 (APLP1) is involved in pathological α‐synuclein transmission, but its role Parkinson's disease (PD) progression has not been explored. Objective This study investigates APLP1 as a potential predictor for motor and cognitive deterioration PD. Methods Plasma levels were measured PD patients from the Huashan Hospital Disease (HSPD) Progression Markers Initiative (PPMI) cohorts. A total of 916 participants recruited HSPD cohort, 171 PPMI...
Abstract Background 14,15-Epoxyeicosatrienoic acids (14,15-EETs) generated from arachidonic acid by cytochrome P450 epoxygenases have beneficial effects in certain cardiovascular diseases, and increased 14,15-EET levels protect the system. 14,15-EETs are rapidly hydrolyzed soluble epoxide hydrolase (sEH) to corresponding 14,15-dihydroxyeicosatrienoic (14,15-DHETs), which generally less biologically active but more stable metabolite. A functionally relevant polymorphism of CYP2J2 gene is...
No well-defined protocols currently exist regarding the optimal rate and duration of normal saline administration to prevent contrast-induced acute kidney injury (CI-AKI) in patients with renal insufficiency.
Many of the currently available COVID-19 vaccines and therapeutics are not effective against newly emerged SARS-CoV-2 variants. Here, we developed metallo-enzyme domain angiotensin converting enzyme 2 (ACE2)-the cellular receptor SARS-CoV-2-into an IgM-like inhalable molecule (HH-120). HH-120 binds to Spike (S) protein with high avidity confers potent broad-spectrum neutralization activity all known variants concern. was as inhaled formulation that achieves appropriate aerodynamic properties...
In general, for real-time quantitative polymerase chain reaction (qPCR), normalization strategies use a reference gene as control and to avoid the introduction of experimental errors expression this should not vary in response changing conditions. However, many genes has been reported considerably and, without appropriate normalization, profile target can be misinterpreted. study, levels seven commonly used (ACT, GAPDH, 28srRNA, RPL3, α-tubulin, UBC, TBP) were detected at different...
Estrogen was reported to protect against obesity, however the mechanism remains unclear. We aimed investigate impact of 17β-estradiol (17β-E2) on triglyceride metabolism in adipocytes with or without lipopolysacchride (LPS) stimulating, providing novel potential for estrogen action. 3T3-L1 were cultured and differentiated into mature vitro. The cells divided six groups: (i) control group, treated 0.1% DMSO alone; (ii) 17β-E2 1, 0.1, 0.001 μM 48 h; (iii) plus MPP pre-treated 10 (a selective...
Estrogen had been found to be negatively associated with serum triglyceride (TG) levels. Apolipoprotein A5 (APOA5), a novel member of apolipoprotein family, was reported have strong ability decrease concentrations TG. Clinical data APOA5 were higher in woman than that men, and the negative relationship between TG levels more significant woman. These suggests may involve estrogen actions. Therefore, we hypothesize up-regulates subsequently decreases We will design following experiments test...
<title>Abstract</title> Wuhan encountered a serious attack in the first round of COVID-19 pandemic which has resulted worldwide consequences politically and economically. Based on Weibo help data, we inferred spatial distribution pattern epidemic situation its impacts. Seven urban factors, i.e. growth, general hospital, commercial facilities, subway station, landuse mixture, aging ratio, road density, were selected for validation with ordinary linear model, former six presented globally...
In recent years, machine learning has gradually been applied to building energy-saving designs reduce the time consumption of optimization screening stage. However, since most existing research scholars come from fields computers and engineering, application technology mostly involves complex programming as well software in field which requires multiple be coupled achieve. view differences between disciplines high threshold, these theories are difficult apply promote practical work...
Throughout history, rivers and lakes have wielded a profound influence on the dynamics of urban transportation expansion. To illustrate this phenomenon, we turn to century-long evolution road network in Wuhan, China, as case study. The study aims explore relationship framework between water bodies transportation, characterized by sequence “strong connection” “weakened connection”, then “mutual restriction”, ultimately benefit”. Additionally, analysis impact mechanisms at different stages...
Ischemic arrhythmias are the main causes of sudden cardiac death. It has been reported that soluble epoxide hydrolase inhibitors (sEHis) could prevent arrhythmias; however, underlying molecular mechanisms remain unclear. In recent years, proarrhythmic role microRNA-1 (miR-1) investigated. This study aimed to elucidate whether sEHis prevented ischemic by suppressing miR-1. The primary neonatal mouse ventricular myocyte model miR-1 overexpression was established incubating with agonist...
The sex ratio is an important factor affecting the economic benefits of duck groups in process hemp breeding. However, current manual counting method inefficient, and results are not always accurate. On one hand, ducks constant motion, on other relies manpower; thus, it difficult to avoid repeated missed counts. In response these problems, there urgent need for efficient accurate way calculating promote farming industry. Detecting requires male female ducks. We established world's first...
Ventricular pseudoaneurysm (PSA) is a rare, yet life-threatening complication of myocardial infarction, cardiac surgery, and transcatheter valve replacement. Although conventional surgery the preferred treatment strategy, closure has emerged as an effective alternative in selected candidates. In this report, we describe successful two unique cases ventricular (PSA): first, complex post-myocardial infarction left PSA (LVPSA) with multi-communications, second, case post-traumatic right (RVPSA)...
A low urine flow rate is a marker of acute kidney injury. However, it unclear whether high associated with reduced risk contrast-induced nephropathy (CIN) in high-risk patients. We conducted this study to evaluate the predictive value for CIN following emergent percutaneous coronary intervention (PCI). prospectively examined 308 patients undergoing PCI who provided consent. The 24-hour postprocedural rate, adjusted by weight (UR/W, mL/kg/h) and divided into quartiles, was assessed using...