A5048745932- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Restless Legs Syndrome Research
- Nuclear Receptors and Signaling
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Vibration Control and Rheological Fluids
- Neurological diseases and metabolism
- Ginkgo biloba and Cashew Applications
- Botulinum Toxin and Related Neurological Disorders
- Autophagy in Disease and Therapy
- Nanoparticle-Based Drug Delivery
- Metabolism and Genetic Disorders
- Functional Brain Connectivity Studies
- Drug Solubulity and Delivery Systems
- MicroRNA in disease regulation
- RNA regulation and disease
- Advanced Drug Delivery Systems
- Balance, Gait, and Falls Prevention
- Geophysics and Sensor Technology
- Pelvic and Acetabular Injuries
- Hip and Femur Fractures
- Nerve injury and regeneration
- Autism Spectrum Disorder Research
- Child Development and Digital Technology
Huashan Hospital
2016-2025
Nanjing Medical University
2024-2025
Fudan University
2016-2025
Nanjing Brain Hospital
2024-2025
State Key Laboratory of Medical Neurobiology
2022-2024
Guiyang Medical University
2023-2024
ShanghaiTech University
2024
Huadong Hospital
2023
Beijing Institute of Technology
2023
Marine Design & Research Institute of China
2022
Abstract There is currently no reliable and easily applicable diagnostic marker for Parkinson’s disease (PD). The aims of the present study were to compare expression profiles microRNA29 family (miR-29s) in blood serum from patients with PD healthy controls clarify whether miR-29s correlated severity, duration or L-dopa therapy depends on gender age patients. levels 80 unaffected assessed by reverse transcription-quantitative real-time PCR. PCR products confirmed cloning sequencing....
Abstract Glial fibrillary acidic protein (GFAP) has been suggested as a biomarker for reactive astrogliosis. We measured the levels of plasma GFAP by Simoa in 60 patients with PD normal cognition, 63 mild cognitive impairment (PD-MCI), 24 dementia (PDD) and 15 healthy controls. A subgroup PD-MCI ( n = 31) was followed up 4.1 ± 2.3 years. Compared controls, were elevated PDD (adjusted P < 0.001) 0.013) negatively correlated Mini Mental State Examination (MMSE) score participants. Plasma...
Rapid eye movement sleep behavior disorder (RBD) is increasingly recognized in patients with tauopathies, but its significance and underpinnings remain unclear. To address this gap, we investigated the prevalence of self-reported RBD progressive supranuclear palsy (PSP) explored clinical imaging correlates using 18F-florzolotau PET imaging. We consecutively enrolled meeting 2017 Movement Disorder Society criteria for PSP at a Chinese tertiary hospital between May 2019 March 2022. Patients...
Abstract Idiopathic rapid eye movement sleep behaviour disorder (RBD) is now recognized as an early manifestation of α-synucleinopathies. Increasing experimental studies demonstrate that manipulative lesion or inactivation the neurons within sublaterodorsal tegmental nucleus (also known subcoeruleus in humans) can induce RBD-like behaviours animals. As current RBD animal models are not established on basis α-synucleinopathy, they do represent pathological substrate idiopathic and thus cannot...
Spherical nanoparticles as a classic delivery vehicle for anticancer drugs have been extensively investigated, but study on the shape of has received little attention until now. Here, nonspherical poly(ethylene glycol) (PEG)-stabilized bilayer nanodisk consisting 1,2-distearyl-sn-glycero-3-phosphocholine (DSPC) and PEG5000-glyceryl distearate (PEG5K-GCDS) was prepared doxorubicin delivery, called DOX-Disks. The disks were open structures, with hydrophobic discoid center built by DSPC...
This study aimed to characterize the clinical features and related cerebral glucose metabolism pattern of cognitive impairments in Parkinson's disease (PD) with positron emission tomography (PET) imaging. We recruited 168 PD patients 100 age-matched healthy controls similar education gender distribution. All those enrolled underwent assessment including unified rating scale motor score, Hoehn Yahr scale, comprehensive neuropsychological tests domains executive function, attention, memory,...
Purpose To characterize cerebral glucose metabolism associated with different cognitive states in Parkinson's disease (PD) using 18F-fluorodeoxyglucose (FDG) and Positron Emission Tomography (PET). Methods Three groups of patients were recruited this study including PD dementia (PDD; n = 10), mild impairment (PD-MCI; 20), no (PD-NC; 30). The matched for age, sex, education, duration, motor disability, levodopa equivalent dose Geriatric Depression Rating Scale (GDS) score. All subjects...
The pathological hallmarks of Parkinson's disease (PD) are the progressive loss dopaminergic (DA) neurons in substantia nigra pars compacta (SNpc) and presence overactivated glial cells neuroinflammation. Nuclear factor kappa-light-chain-enhancer activated B (NF-κB) c-Rel subunit is closely related progress PD, however roles mechanisms PD development remain unclear. Here, neurotoxins-induced models, dynamic changes NF-κB its functions were evaluated. We found that was rapidly nigrostriatal...
Abstract So far, over 20 causative genes of monogenic Parkinson’s disease (PD) have been identified. Some non-parkinsonian entities may also manifest with parkinsonism mimicking PD. This study aimed to investigate the genetic characteristics clinically diagnosed PD early onset age or family history. A total 832 patients initially were enrolled, which, 636 classified into early-onset group and 196 familial late-onset group. The testing included multiplex ligation-dependent probe amplification...
Abstract Background Amyloid precursor‐like protein 1 (APLP1) is involved in pathological α‐synuclein transmission, but its role Parkinson's disease (PD) progression has not been explored. Objective This study investigates APLP1 as a potential predictor for motor and cognitive deterioration PD. Methods Plasma levels were measured PD patients from the Huashan Hospital Disease (HSPD) Progression Markers Initiative (PPMI) cohorts. A total of 916 participants recruited HSPD cohort, 171 PPMI...
Background Asymmetry in motor dysfunction and associated dopaminergic deficit is a common characteristic of Parkinson's disease (PD), yet potential explanations remain mysterious. Hereby, we assessed whether asymmetry the nasal cavity related to PD patients. Methods This cross-sectional, multi-center observational study included 761 patients from three cohorts. First, analyzed data Huashan Parkinsonian PET Imaging Database (March 2011 February 2020), which served as primary cohort (n=333)....
The recently proposed body-first and brain-first subtypes are classified based on the initial localization of α-synuclein inclusions. This study investigated plasma biomarkers cerebral glucose metabolism characteristics in putative PD subjects. patients without possible RBD (PDpRBD–) (n = 58) with symptoms discovered before motor (PDpRBD+) 43) were recruited. Single-molecule array (SimoA) was used for measuring biomarkers, including glial fibrillary acidic protein (GFAP), neurofilament light...
The leucine-rich repeat kinase 2 (LRRK2) gene is one of the most common genetic causes autosomal dominant Parkinson's disease (PD) and a risk factor for sporadic PD. However, aged mice with LRRK2 point mutations fail to exhibit age-related PD-associated behavioral pathological impairments. We generated novel mouse model harboring LRRK2.p.N1437D mutation (c.4309 A > G; NM_98578). Here, homozygous N1437D mutation, but not heterozygous led an increase in autophosphorylation, substrate...
Background Marijuana impairs the brain development and function among adolescents, but little is known about whether marijuana use associated with subjective cognitive decline (SCD) adults. Objective We investigated cross-sectional association between past-year SCD in a representative sample of US adults aged 45 years older. Methods The study population included 100,685 participants from five cycles Behavioral Risk Factor Surveillance System (BRFSS). Participants self-reported their past...
This study aimed to examine the potential involvement of inflammatory imbalance and OFC subregion structure in pathogenesis agitation. In this 119 schizophrenia patients were categorized into different subgroups agitation using two-step cluster analysis. Peripheral cytokine examined all subjects. Patients assessed for immune-inflammatory response system compensatory immunoregulatory reflex (IRS/CIRS) reflecting level imbalance. The immune biomarkers mainly include M1 (IL-6, IL-1β, IFN-α...
High-strength and high-modulus epoxy resins are key elements for preparing carbon-fiber-reinforced polymer composites, which play an irreplaceable role in aerospace. In this study, five optimal systems were developed utilizing the reverse design strategy. The strategy was based on ideal resin curing agent structures offered by AI platform, rules summarized to create optimum formulation. formulations used m-phenylenediamine (MPD) as principal agent, modified with 10 wt%...
The basal ganglia are important structures for the release of dopamine in limbic circuits midbrain, and striatum globus pallidus major nuclei ganglia, dysfunction these regions has been basis many models that have attempted to explain underlying mechanisms schizophrenia symptoms. purpose this study was investigate changes volume subregion three different stages schizophrenia, analyze whether were related antipsychotic drugs
Abstract A new Parkinson’s disease (PD) subtyping model has been recently proposed based on the initial location of α-synuclein inclusions, which divides PD patients into brain-first subtype and body-first subtype. Premotor RBD proven to be a predictive marker We found compared without possible (PD pRBD– , representing subtype), with premotor pRBD+ subtype) had lower Movement Disorders Society Unified Disease Rating Scale part III (MDS UPDRS-III) score ( p = 0.022) at baseline but presented...