A5034648482- Schizophrenia research and treatment
- Mental Health Treatment and Access
- Mental Health and Psychiatry
- Bipolar Disorder and Treatment
- Mental Health Research Topics
- Child and Adolescent Psychosocial and Emotional Development
- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Functional Brain Connectivity Studies
- COVID-19 and Mental Health
- Obsessive-Compulsive Spectrum Disorders
- Psychosomatic Disorders and Their Treatments
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Family Caregiving in Mental Illness
- Quantum Chromodynamics and Particle Interactions
- Particle Detector Development and Performance
- Tryptophan and brain disorders
- Attention Deficit Hyperactivity Disorder
- Treatment of Major Depression
- Health disparities and outcomes
- Mindfulness and Compassion Interventions
- Resilience and Mental Health
- Suicide and Self-Harm Studies
- Autism Spectrum Disorder Research
- Health Systems, Economic Evaluations, Quality of Life
University of Hong Kong
2016-2025
Chinese University of Hong Kong
2016-2025
Hospital Sultanah Bahiyah
2025
University of Pennsylvania
2025
Huashan Hospital
2025
Fudan University
2025
National Cheng Kung University Hospital
2025
Hong Kong Polytechnic University
2020-2024
State Key Laboratory of Brain and Cognitive Science
2017-2024
HKU-Pasteur Research Pole
2021-2024
The coronavirus disease 2019 (COVID-19) pandemic is having a profound impact on the health and development of children worldwide. There limited evidence COVID-19 its related school closures disease-containment measures psychosocial wellbeing children; little research has been done characteristics vulnerable groups factors that promote resilience.We conducted large-scale cross-sectional population study Hong Kong families with aged 2-12 years. Parents completed an online survey family...
Abstract This international guideline proposes improving clozapine package inserts worldwide by using ancestry-based dosing and titration. Adverse drug reaction (ADR) databases suggest that is the third most toxic in United States (US), it produces four times higher pneumonia mortality than agranulocytosis or myocarditis. For trough steady-state serum concentrations, therapeutic reference range narrow, from 350 to 600 ng/mL with potential for toxicity ADRs as concentrations increase....
Rapid eye movement sleep behavior disorder (RBD) is increasingly recognized in patients with tauopathies, but its significance and underpinnings remain unclear. To address this gap, we investigated the prevalence of self-reported RBD progressive supranuclear palsy (PSP) explored clinical imaging correlates using 18F-florzolotau PET imaging. We consecutively enrolled meeting 2017 Movement Disorder Society criteria for PSP at a Chinese tertiary hospital between May 2019 March 2022. Patients...
Impairments of attention and memory are evident in early psychosis, associated with functional disability. In a group stable, medicated women patients, we aimed to determine whether participating aerobic exercise or yoga improved cognitive impairments clinical symptoms. A total 140 female patients were recruited, 124 received the allocated intervention randomized controlled study 12 weeks compared waitlist group. The primary outcomes functions including attention. Secondary outcome measures...
Importance Mental health issues among young people are increasingly concerning. Conventional psychological interventions face challenges, including limited staffing, time commitment, and low completion rates. Objective To evaluate the effect of a low-intensity online intervention on in Hong Kong experiencing moderate or greater mental distress. Design, Setting, Participants This randomized clinical trial was conducted from May 12, 2022, to September 22, 2023, Kong. (aged 12-30 years) were...
Objective: The aim of the current study was to investigate rates and predictors symptomatic remission recovery in patients presenting with first-episode psychosis 3 years after treatment initiation. Methods: Seven hundred participants aged 15–25 consecutively enrolled a territory-wide early intervention programme Hong Kong from July 2001 August 2003 fulfilled inclusion criteria, 539 completing 3-year follow-up. Baseline follow-up variables were collected via systematic medical file review....
<h3>Importance</h3> Patients with schizophrenia have a substantially higher suicide rate than the general public. Early intervention (EI) services improve short-term outcomes. However, little is known about association of EI reduction in long term. <h3>Objective</h3> To examine 2-year service patients first-episode schizophrenia-spectrum (FES) disorders during 12 years and risk factors for early late suicide. <h3>Design, Setting, Participants</h3> This historical control study compared 617...
Background. Despite evidence on the short-term benefits of early intervention (EI) service for psychosis, long-term outcome studies are limited by inconsistent results. This study examined 10-year outcomes patients with first-episode psychosis who received 2-year territory-wide EI compared to those standard care (SC) in Hong Kong using an historical control design. Method. Consecutive between 1 July 2001 and 30 June 2002, diagnosis schizophrenia-spectrum disorders, were identified matched SC...
Numerous early intervention services targeting young people with psychosis have been established, based on the premise that reducing treatment delay and providing intensive in initial phase of can improve long-term outcome.To establish effect extending a specialised for first-episode by 1 year.A randomised, single-blind controlled trial (NCT01202357) compared 1-year extension step-down care patients who had all received 2-year programme psychosis.Patients receiving an additional year better...
Studies on the long-term development and early predictors of treatment-resistant schizophrenia (TRS) clozapine-resistant TRS (CR-TRS) in patients with first-episode schizophrenia-spectrum disorders (FES) are limited have not considered impact intervention services (EIS). This study aimed to explore CR-TRS among FES over 12 years follow-up. Of 1234 FES, 15% developed TRS. A total 450 or schizoaffective disorder were included a nested case-control (157 293 non-TRS). Younger age onset, poorer...
Abstract Background Better understanding of interplay among symptoms, cognition and functioning in first-episode psychosis (FEP) is crucial to promoting functional recovery. Network analysis a promising data-driven approach elucidating complex interactions psychopathological variables psychosis, but has not been applied FEP. Method This study employed network examine inter-relationships wide array encompassing psychopathology, premorbid onset characteristics, cognition, subjective...
Abstract Background Schizophrenia is a longstanding condition and most patients experience multiple relapse in the course of condition. High expressed emotion (HEE) has been found to be predictor relapse. This meta-analysis meta-regression examined association global EE specifically focusing on timing domains. Methods Random-effects model was used pool effect estimates. Multiple random-effects compute moderator analysis. Putative moderators including culture, measurements, age, length study...
Abstract Background The development of a valid and simple-to-use self-administered tool in Asian adolescents for clinical screening intervention remains limited. present study assessed the psychometric characteristics validity Generalised Anxiety Disorder Scale-7 (GAD-7) among Hong Kong. Methods Epidemiological data from 3,261 Kong aged 15 - 24 years were analysed construct validity, criterion concurrent Rasch Model. All analyses age- gender-weighted according to distributions Kong’s general...
BackgroundHong Kong is among the many populations that has experienced combined impacts of social unrest and COVID-19 pandemic. Despite concerns about further deteriorations in youth mental health globally, few epidemiological studies have been conducted to examine prevalence correlates major depressive episode (MDE) other psychiatric disorders across periods population-level changes using diagnostic interviews.MethodsWe a territory-wide household-based study from 2019 2022 targeting young...
Purpose: This study aimed to meta-analysis the level of internalised stigma experienced by individuals with psychosis worldwide, and impact cultural differences, economic status studied regions duration illness on their levels stigma. Clinical individual factors associated resistance were also systematically reviewed. Methods: A systematic search keywords two scholarly databases conducted. The individualism index countries or where studies conducted was retrieved from Hofstede’s updated...
This article aims to describe the Hong Kong experience in developing and implementing an early psychosis programme.In 2001, Early Assessment Service for Young People with Psychosis programme was launched Kong, providing both educational service components. Public education includes promotion of timely help-seeking, accessible channels knowledge psychosis. The 2-year phase-specific intervention intensive medical follow-up individualized psychosocial intervention. has adopted case-management...
Background Cognitive impairment is a core feature of schizophrenia. Its relationship with duration untreated psychosis (DUP), potentially malleable prognostic factor, has been less studied, inconsistent findings being observed in the literature. Previous research investigating such was mostly cross-sectional and none those prospective studies had follow-up beyond 2 years. Method A total 93 Hong Kong Chinese aged 18 to 55 years presenting first-episode schizophrenia-spectrum disorder were...