A5041183593- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Mental Health and Psychiatry
- Animal Genetics and Reproduction
- Electroconvulsive Therapy Studies
- Treatment of Major Depression
- Chromosomal and Genetic Variations
- Pharmacological Effects and Toxicity Studies
- Renal function and acid-base balance
- Cerebrovascular and genetic disorders
- Epilepsy research and treatment
- Healthcare Decision-Making and Restraints
- Psychosomatic Disorders and Their Treatments
- Pharmacogenetics and Drug Metabolism
- Genomic variations and chromosomal abnormalities
- Pharmaceutical Practices and Patient Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Alcoholism and Thiamine Deficiency
- Liver Disease and Transplantation
- Psychiatric care and mental health services
- Neurological diseases and metabolism
- Child and Adolescent Psychosocial and Emotional Development
- Pharmaceutical studies and practices
- Mitochondrial Function and Pathology
Okayama Psychiatric Medical Center
2018-2024
Tokushima University
2015
Abstract This international guideline proposes improving clozapine package inserts worldwide by using ancestry-based dosing and titration. Adverse drug reaction (ADR) databases suggest that is the third most toxic in United States (US), it produces four times higher pneumonia mortality than agranulocytosis or myocarditis. For trough steady-state serum concentrations, therapeutic reference range narrow, from 350 to 600 ng/mL with potential for toxicity ADRs as concentrations increase....
Abstract Introduction No study has investigated the impact of smoking habits and concomitant valproic acid (VPA) use on clinical outcomes in maintenance treatment with clozapine. Thus, we aimed to examine effect VPA relapse during first year after discharge patients treatment‐resistant schizophrenia (TRS) receiving Methods This retrospective cohort included TRS who were initiated clozapine hospitalization discharged between April 2012 January 2021 two tertiary psychiatric hospitals Japan....
Psychopharmacotherapy for patients with schizophrenia in Japan has a long history of polypharmacy, which is rare worldwide but remains critical problem. One reason this that clozapine was not available until 2009. We aimed to investigate the changes psychopharmacotherapy over 12 years pre- and post-introduction clarify how changed introduction clozapine. retrospectively collected data from medical records inpatients diagnosed at Okayama Psychiatric Medical Center. Chlorpromazine equivalent...
Sex chromosomes of extant eutherian species are too ancient to reveal the process that initiated sex-chromosome differentiation. By contrast, neo-sex generated by sex-autosome fusions recent origin in Tokudaia muenninki expected be evolutionarily 'young', and therefore provide a good model which elucidate early phases sex chromosome evolution. Here we describe genomic evolution T. differentiation.FISH mapping male, using 50 BAC clones as probes, revealed no chromosomal rearrangements between...
Clozapine is generally recommended to be prescribed in a divided dosing regimen based on its relatively short plasma half-life. However, there has been little evidence support the superiority of clozapine over once-daily dosing. To our knowledge, have no studies examining differences actual concentrations or adverse effects between 2 strategies clozapine. We aimed compare and regimens, examine relationships these regimens with psychiatric symptoms clozapine.We analyzed data from 108...
Although reported for Caucasians, changes in plasma clozapine levels after smoking cessation East Asians remain unclear. We here investigated before and Japanese inpatients with schizophrenia. conducted a retrospective chart review of 14 schizophrenia who were being treated between June 1, 2019, July 31, 2019 smokers as the day on which ban was instituted tertiary public psychiatric hospital. The primary outcome individual differences ban, compared using paired t-tests. mean level...
This retrospective cohort study aimed to investigate the longitudinal changes in clozapine dose over a 5-year period patients with treatment-resistant schizophrenia (TRS). Patients TRS who were administered at hospital between April 2012 and December 2016 continued treatment for least 1 year included. Clozapine doses compared dose-fixation point, defined as when same regimen of had been 8 weeks or longer, post-dose-fixation phase, 12, 36 60 months after initiation. We included 103 found no...