A5058502260- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Bipolar Disorder and Treatment
- Health disparities and outcomes
- Homelessness and Social Issues
- Advanced Neuroimaging Techniques and Applications
- Electrolyte and hormonal disorders
- Tryptophan and brain disorders
- Mindfulness and Compassion Interventions
- Acute Ischemic Stroke Management
- Neurological disorders and treatments
- Geriatric Care and Nursing Homes
- Dementia and Cognitive Impairment Research
- Lymphoma Diagnosis and Treatment
- Nutrition and Health in Aging
- Hematopoietic Stem Cell Transplantation
- Intracerebral and Subarachnoid Hemorrhage Research
- Lung Cancer Treatments and Mutations
- Treatment of Major Depression
- Traumatic Brain Injury and Neurovascular Disturbances
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Long-Term Effects of COVID-19
- Epilepsy research and treatment
- Diet and metabolism studies
- Neurological and metabolic disorders
Jazz Pharmaceuticals (United States)
2023-2025
British Columbia Children's Hospital
2024
University of British Columbia
2015-2024
BC Mental Health & Substance Use Services
2021-2023
AmerisourceBergen (United States)
2020
University of British Columbia Hospital
2017
Centre for Movement Disorders
2016
Ontario Institute for Cancer Research
1996
Impairments of attention and memory are evident in early psychosis, associated with functional disability. In a group stable, medicated women patients, we aimed to determine whether participating aerobic exercise or yoga improved cognitive impairments clinical symptoms. A total 140 female patients were recruited, 124 received the allocated intervention randomized controlled study 12 weeks compared waitlist group. The primary outcomes functions including attention. Secondary outcome measures...
Objectives A sizable fraction of people with bipolar I disorder ( BDI ) experience a deteriorating clinical course increasingly frequent mood episodes and chronic disability. This is believed to result from neurobiological illness progression, or neuroprogression. Excessive weight gain predicts neuroprogression across multiple brain illnesses, but no prospective studies have investigated this in . The objective study was determine whether patients who experienced clinically significant CSWG...
Abstract Background: HER2 has emerged as a target for precision therapies in BTC. We describe the RW tx patterns and overall survival (OS) of pts with advanced HER2-overexpressing BTC treated 2L. Methods: This retrospective observational study used Flatiron Health Electronic Record-derived, deidentified database (01/2011 to 12/2023). Pts (IHC 3+) who received 2L ≥6 months (mo) potential follow-up time were included OS analysis. Follow-up began at initiation (index) earliest last recorded...
4101 Background: Zanidatamab-hrii, a bispecific HER2-directed antibody, received accelerated approval for adults with previously treated, unresectable or metastatic HER2-positive (IHC 3+) BTC based on results from the single-arm phase 2 HERIZON-BTC-01 trial. The here compare survival outcomes zanidatamab-hrii vs comparable RW cohort of patients who second-line (2L) chemotherapy. Methods: (NCT04466891) evaluated (20 mg/kg IV every weeks) in HER2-amplified, locally advanced (gallbladder cancer...
Background Reduced cortical gray-matter volume is commonly observed in patients with psychosis. Cortical a composite measure that includes surface area, thickness and gyrification. These three indices show distinct maturational patterns may be differentially affected by early adverse events. The study goal was to determine the impact of two obstetrical complications (OCs) on morphology. Method A detailed birth history MRI scans were obtained for 36 first-episode psychosis 16 healthy...
We aim to describe the burden, characteristics, and cognitive associations of cerebral small vessel disease in a Canadian sample living with multimorbidity precarious housing.Participants received T1, T2-fluid-attenuated inversion recovery, susceptibility-weighted imaging 3T magnetic resonance sequences comprehensive clinical, laboratory, assessments. Cerebral burden was characterized using modified Small Vessel Disease (mSVD) score. One point each given for moderate-severe white matter...
We previously reported that patients with early-stage bipolar disorder, but not healthy comparison controls, had body mass index (BMI)-related volume reductions in limbic brain areas, suggesting the structural changes characteristic of disorder were more pronounced increased weight.To determine whether most consistently neurochemical abnormality glutamate/glutamine (Glx), was also prominent higher BMI.We used single-voxel proton magnetic resonance spectroscopy to measure hippocampal Glx 51...
Background Homeless and vulnerably housed individuals are at increased risk for multimorbidity compared with the general population. We assessed prevalence of brain infarcts on neuroimaging associations vascular factors cognitive performance in a prospective study residents living marginal housing. Methods Results Two hundred twenty-eight participants underwent structured clinical interviews, targeted clinical, laboratory, neuropsychological assessments, magnetic resonance imaging T
Abstract We previously reported that higher body mass index (BMI) was associated with greater hippocampal glutamate+glutamine in people bipolar disorder (BD), but not non-BD healthy comparator subjects (HSs). In the current report, we extend these findings by examining impact of BD diagnosis and BMI on volumes concentrations several additional neurochemicals 57 early-stage patients 31 HSs. Using 3-T magnetic resonance imaging spectroscopy, measured bilateral four relevant to BD: N...
The authors examined associations between complementary fronto-temporal structural brain measures (gyrification, cortical thickness) and neurocognitive profiles in a multimorbid, socially marginalized sample.Participants were recruited from single-room occupancy hotels downtown community courthouse (N = 299) grouped on multiple domains using cluster analysis. Subsequently, the evaluated whether indices, proxy of neurodevelopment acquired insult/risk exposure differentiated members 3 distinct...
Abstract With sufficient drug exposure, some individuals develop transient psychotic symptoms referred to as ‘substance‐induced psychosis’ (SIP), which closely resemble the observed in schizophrenia spectrum disorders. The comparability presentation between SIP and schizophrenias suggests that similar underlying neural deficits may contribute emergence of psychosis across these Only a small number studies have investigated structural alterations SIP, all been limited volumetric imaging...
To investigate whether circulating leptin levels are associated with energy expenditure in healthy humans, doubly labeled water measurements and food intake assessment were carried out 27 women (mean age, 48.6 years; weight, 61.9 kg; body mass index, 23.2). Energy was determined over 13 days. Food measured by 7-day records. Leptin radioimmunoassay. level strongly percentage fat (r = 0.59; p < 0.001), 0.60; index 0.41; 0.03), but no correlation observed 0.02; 0.93). After controlling for fat,...
Introduction Cognition is impaired in homeless and vulnerably housed persons. Within this heterogeneous multimorbid group, distinct profiles of cognitive dysfunction are evident. However, little known about the underlying neurobiological substrates. Imaging structural covariance networks provides a novel investigative strategy to characterizing relationships between brain structure function within these different subgroups. Method Participants were 208 Cluster analysis was used group...
ObjectivePersons who are homeless or marginally housed exhibit significant cognitive dysfunction, with memory being the most impaired domain. Hippocampal subfield volumes have been found to differentially relate component processes of memory. The neural correlates not previously examined in marginalized persons understudied and underserved. We whether hippocampal subfields entorhinal cortex uniquely related indices verbal episodic using Hopkins Verbal Learning Test – Revised.