A5102721386- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Screening and Detection
- Cancer Genomics and Diagnostics
- Anorectal Disease Treatments and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Genetic factors in colorectal cancer
- GDF15 and Related Biomarkers
- Cancer-related gene regulation
- Macrophage Migration Inhibitory Factor
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Gastric Cancer Management and Outcomes
- Cancer Cells and Metastasis
- Single-cell and spatial transcriptomics
- Galectins and Cancer Biology
- Hepatocellular Carcinoma Treatment and Prognosis
- Protein Tyrosine Phosphatases
- AI in cancer detection
- Diabetes Management and Research
- Venous Thromboembolism Diagnosis and Management
- Artificial Intelligence in Healthcare and Education
- Diabetes Management and Education
Changhai Hospital
2020-2025
Second Military Medical University
2017-2025
Second Hospital of Shanxi Medical University
2025
Shanxi Medical University
2025
Yahoo (United Kingdom)
2023
Barro Colorado Island
2023
National Natural Science Foundation of China
2023
China Postdoctoral Science Foundation
2023
Although the recommended minimal examined lymph node (ELN) number in rectal cancer (RC) is 12, this standard remains controversial because of insufficient evidence. We aimed to refine definition by quantifying relationship between ELN number, stage migration and long-term survival RC.Data from a Chinese multi-institutional registry (2009-2018) Surveillance, Epidemiology, End Results (SEER) database (2008-2017) on stages I-III resected RC were analysed determine count, migration, overall (OS)...
Objective: To explore the safety and efficacy of neoadjuvant chemoradiotherapy (nCRT) combined with a PD-1 antibody in improving complete clinical response (cCR) organ preservation patients ultra-low rectal cancer. Methods: This was prospective phase II, single-arm, open-label trial. Patients confirmed pMMR status T 1-3a N 0-1 M 0 retcal adenocarcinoma were included. Long-course delivered to dose 50 Gy. A added 2 weeks after first radiotherapy session, two courses administered. After...
Anastomotic leakage (AL) is one of the commonest and most serious complications after rectal cancer surgery. The previous analyses on predictors for AL included small-scale patients, their prediction models performed unsatisfactorily.Clinical data 5,220 patients who underwent anterior resection were scrutinized to create a model via random forest classifier. Additionally, 836 served as test dataset. Patients diagnosed with within 6 months' follow-up recorded. A total 20 candidate factors...
e15603 Background: Neoadjuvant chemoradiotherapy (nCRT) not only could bring tumor downsizing and downstaging but also achieve clinical complete response (cCR) or pathological (pCR). Although immunotherapy benefits MSI-H/dMMR rectal cancer patients, little is observed in MSS/pMMR patients. Several trials including VOLTAGE trial demonstrated that a combination of PD-1 inhibitor nCRT result promising even But the elucidation regarding organ preservation after treatment lacking. Watch Wait...
Background Most prognostic signatures for colorectal cancer (CRC) are developed to predict overall survival (OS). Gene predicting recurrence-free (RFS) rarely reported, and postoperative recurrence results in a poor outcome. Thus, we aim construct robust, individualized gene signature that can both OS RFS of CRC patients. Methods Prognostic genes were significantly associated with GSE39582 TCGA cohorts screened via univariate Cox regression analysis Venn diagram. These then submitted least...
Background . The prognostic value of tumor deposit (TD) count in colorectal cancer (CRC) patients has been rarely evaluated. This study is aimed at exploring the TD and finding out optimal cutoff point to differentiate prognoses TD-positive CRC patients. Method Patients diagnosed with from Surveillance, Epidemiology, End Results (SEER) database January 1, 2010, December 31, 2012, were analyzed. X-tile program was used identify training cohort, a validation cohort test this after propensity...
To investigate the clinicopathological features and prognosis of synchronous metachronous multiple primary colorectal cancer.
Background: Although the surgical treatment strategy for rectal cancer (RC) is usually based on preoperative diagnosis of lymph node metastasis (LNM), accurate LNM has been a clinical challenge. In this study, we developed machine learning (ML) models to predict status before surgery privacy-preserving computing platform (PPCP) and created web tool help clinicians with treatment-based decision-making in RC patients. Patients methods: A total 6578 patients were enrolled study. ML models,...
: The tumor microenvironment (TME) plays a critical role in shaping progression and determining the outcome of therapeutic response. In this study, we aimed to generate comprehensive cellular landscape colorectal cancer (CRC) TME. We generated single-cell atlas by collecting CRC cases that have been uploaded online database conducting an in-depth secondary analysis. then carried out spatial transcriptomic sequencing multiple immunohistochemical analyses verify results Moreover, applied our...
Simultaneous resection for patients with synchronous colorectal cancer liver metastases (CRLM) remains an optimal option the sake of curability. However, few studies so far focus on outcome this subgroup (who receive simultaneous CRLM). Substantial heterogeneity exists among such and more precise categorization is needed preoperatively to identify those who may benefit from surgery. In study, we formulated internally validated scoring system as option.Clinicopathological follow-up data 234...
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Abstract Background: T cells, the key mediators of tumor destruction, have a considerable impact on prognosis. However, clinical significance cell-associated biomarkers in colorectal cancer (CRC) haven’t been well understood. The aim this study was to investigate expression profile cell marker genes CRC and develop prognostic signature based these genes. Methods: Single-cell RNA-sequencing (scRNA-seq) data were retrieved from Gene Expression Omnibus (GEO) database. Bulk information...
Protein tyrosine phosphatase SHP2 activates RAS signaling, which is a novel target for colorectal cancer (CRC) therapy. However, inhibitor monotherapy ineffective metastatic CRC and combination therapy required. In this study, we aimed to improve the antitumor efficacy of inhibition try explore resistance mechanism inhibitor. Results showed that WWP1 promoted proliferation cells. Genetic or pharmacological enhanced effect in suppressing tumor growth vitro vivo. may mediate feedback...
Introduction Neoadjuvant chemoradiotherapy (nCRT) could bring tumour shrinking and downstaging increase the probability of organ preservation for patients with low rectal cancer. But ultra-low cancer, there is little possibility preservation. Immunotherapy has been shown to have significant survival benefits in microsatellite instability-high but poor response stable (MSS) patients. Studies demonstrated that radiotherapy immunotherapy synergistic effects cancer treatment. There no existing...
Abstract Background & Aims Metastasis is the main cause of mortality in colorectal cancer (CRC) patients. Exploring mechanisms metastasis great importance both clinical and fundamental CRC research. a highly heterogeneous disease with variable therapeutic outcomes treatment. Approach Results In this study, we applied spatial transcriptomics (ST) to generate tissue-wide transcriptome from two primary tissues their matched liver metastatic tissues. Spatial RNA information showed...