A5009518426- Lung Cancer Treatments and Mutations
- Synthesis and Biological Evaluation
- Bioactive Compounds and Antitumor Agents
- Gastric Cancer Management and Outcomes
- Epigenetics and DNA Methylation
- Biomarkers in Disease Mechanisms
- Colorectal Cancer Surgical Treatments
- Cancer Genomics and Diagnostics
- HER2/EGFR in Cancer Research
- Human Health and Disease
- Inflammation biomarkers and pathways
- Colorectal and Anal Carcinomas
- Cytokine Signaling Pathways and Interactions
- Porphyrin and Phthalocyanine Chemistry
- Colorectal Cancer Treatments and Studies
- Apelin-related biomedical research
- Cancer-related gene regulation
- Cancer Immunotherapy and Biomarkers
Changhai Hospital
2025
Second Military Medical University
2025
University of Electronic Science and Technology of China
2024
Southern Medical University
2024
Cell Technology (China)
2024
Shanghai Jiao Tong University
2024
Zhujiang Hospital
2024
Shanghai Chest Hospital
2024
Hangzhou Normal University
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2020
Objective: To explore the safety and efficacy of neoadjuvant chemoradiotherapy (nCRT) combined with a PD-1 antibody in improving complete clinical response (cCR) organ preservation patients ultra-low rectal cancer. Methods: This was prospective phase II, single-arm, open-label trial. Patients confirmed pMMR status T 1-3a N 0-1 M 0 retcal adenocarcinoma were included. Long-course delivered to dose 50 Gy. A added 2 weeks after first radiotherapy session, two courses administered. After...
Objective: To evaluate the dose, efficacy and tolerability of regorafenib in a real-world clinical setting metastatic colorectal cancer patients. Methods: The data patients with who had received at least two previous treatment lines treated from May 2018 to December 2019 National Cancer Center/Cancer Hospital was retrospectively analyzed. Patients'demographics, treatment, dosimetry, safety survival were collected. primary endpoint overall (OS). Results: A total 114 enrolled this study,...
To evaluate the impact of sequential (first- to third-generation) epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) treatment on top-corrected QT interval (top-QTc) in non-small cell lung cancer (NSCLC) patients. We retrospectively reviewed medical records NSCLC patients undergoing EGFR-TKI at Shanghai Chest Hospital between October 2016 and August 2021. The heart rate (HR), top-QT interval, top-QTc their ECGs were extracted from institutional database analyzed. Logistic...
Rationale: Colorectal cancer (CRC) is a leading cause of cancer-related mortality. Epigenetic modifications play significant role in the progression CRC. KAT7, histone acetyltransferase, has an unclear Methods: In this research, we analyzed expression KAT7 CRC patients and its correlation with prognosis using GEO database, western blot, immunohistochemistry. We assessed impact on cell functions through viability, colony formation, flow cytometry, scratch, transwell assays. Mechanistic...
Objective Endothelial specific molecule-1 (ESM1) is implicated as an oncogene in multiple human cancers. However, the function of ESM1 papillary thyroid cancer (PTC) not well understood. The current study aimed to investigate effect on growth, migration, and invasion PTC provide a novel perspective for treatment. Methods expression levels tissues form 53 tumor tissue samples 59 matching adjacent normal were detected by immunohistochemical analysis. Knockdown TPC-1 SW579 cell lines was...
Objective: To explore the effect of gene polymorphism on workers suffering from noise induced hearing loss (NIHL) . Methods: In May 2019, a case-control study was conducted to select exposed in five factories Zhejiang Province 2017 2018. The average threshold binaural high frequency (3, 4, 6 kHz) >25 dB (A) as NIHL group, and any language (0.5, 1, 2 ≤25 non with 307 people each group. general demographic data, occupational history, pure tone audiometry results oral swab mucosal samples were...