A5086790430- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Macrophage Migration Inhibitory Factor
- Colorectal and Anal Carcinomas
- Ferroptosis and cancer prognosis
- Advanced machining processes and optimization
- Advanced Machining and Optimization Techniques
- PARP inhibition in cancer therapy
- DNA Repair Mechanisms
- Immune Cell Function and Interaction
- Colorectal Cancer Surgical Treatments
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- GDF15 and Related Biomarkers
- Single-cell and spatial transcriptomics
- Immunotherapy and Immune Responses
- Laser Material Processing Techniques
- Cancer therapeutics and mechanisms
Changhai Hospital
2023-2025
Second Military Medical University
2023-2025
Jiangsu University
2023
Abstract Colorectal cancer (CRC) exhibits a complex tumor microenvironment with significant cellular heterogeneity, particularly involving cancer‐associated fibroblasts that influence behavior and metastasis. This study integrated single‐cell RNA sequencing spatial transcriptomics to dissect fibroblast heterogeneity in CRC. Data processing employed Seurat for quality control, principal component analysis dimensionality reduction, t‐Distributed Stochastic Neighbor Embedding visualization....
Introduction Neoadjuvant chemoradiotherapy (nCRT) could bring tumour shrinking and downstaging increase the probability of organ preservation for patients with low rectal cancer. But ultra-low cancer, there is little possibility preservation. Immunotherapy has been shown to have significant survival benefits in microsatellite instability-high but poor response stable (MSS) patients. Studies demonstrated that radiotherapy immunotherapy synergistic effects cancer treatment. There no existing...
One potential cause of cancer is genomic instability that arises in normal cells due to years DNA damage the body. The clinical application radiotherapy and cytotoxic drugs treat based on principle damaging cells. However, benefits these treatments also have negative effects tissue. While there been notable advancements molecular-driven therapy immunotherapy for colorectal (CRC), a considerable portion patients with advanced CRC do not experience any from treatments, leading poor prognosis....