A5101768976- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Phytochemistry and Biological Activities
- Drug-Induced Hepatotoxicity and Protection
- Plant-derived Lignans Synthesis and Bioactivity
- Chronic Myeloid Leukemia Treatments
- Bioactive Natural Diterpenoids Research
- Cardiac Fibrosis and Remodeling
- MicroRNA in disease regulation
- Natural product bioactivities and synthesis
- RNA modifications and cancer
- Synthesis of Organic Compounds
- Cancer Genomics and Diagnostics
- Asymmetric Synthesis and Catalysis
- Cancer, Hypoxia, and Metabolism
- Biological Activity of Diterpenoids and Biflavonoids
- Plant biochemistry and biosynthesis
- Magnesium in Health and Disease
- Microbial metabolism and enzyme function
- Ginger and Zingiberaceae research
- Chemokine receptors and signaling
- Natural Compound Pharmacology Studies
- Health Systems, Economic Evaluations, Quality of Life
- Amyloidosis: Diagnosis, Treatment, Outcomes
- X-ray Diffraction in Crystallography
Anhui Science and Technology University
2021-2025
Anhui University of Science and Technology
2021-2025
Nanchang University
2025
Second Affiliated Hospital of Nanchang University
2025
Shaanxi University of Chinese Medicine
2022-2024
Dalian University
2024
University of Oxford
2021-2024
Jiangxi Science and Technology Normal University
2024
Dalian University of Technology
2024
Bengbu Medical College
2021-2024
The activation of macrophages or microglia in patients' whole body local eyes play significant roles diabetic retinopathy (DR). Mitochondrial function regulates the inflammatory polarization macrophages. Therefore, common mechanism mitochondrial related genes (MRGs) and macrophage polarisation (MPRGs) DR is explored our study to illustrate pathophysiology DR. In this study, using transcriptome data, differentially expressed (DEGs) were firstly analysed for GSE221521, while module MPRGs...
To investigate the therapeutic mechanism of Thesium chinense Turcz. (TCT) for antibiotic-associated diarrhea (AAD). Network pharmacology, KEGG pathway enrichment analysis and molecular docking were used to identify shared targets genes TCT AAD, key signaling pathways binding between active components in core protein targets. In a Kunming mouse model AAD established by intragastric administration lincomycin hydrochloride, effects daily gavage 1% carboxymethyl cellulose sodium or gel solutions...
Objective: Colorectal cancer (CRC) remains a major cause of cancer-related death worldwide. Proteasome 26S subunit ATPase 2 (PSMC2) plays vital roles in regulating cell cycle and transcription has been confirmed to be gene potentially associated with some human tumors. However, the expression correlation molecular mechanism PSMC2 CRC are still unclear. This study aimed investigate role malignant behaviors CRC. Methods: The high protein levels samples were identified by tissue microarray...
Abstract Plant bugs (Miridae species) have become major agricultural pests that cause increasing and severe economic damage. Plant‐mediated RNA interference (RNAi) is emerging as an eco‐friendly, efficient, reliable strategy for pest management. In this study, we isolated characterized a lethal gene of Apolygus lucorum named it LIM ( AlLIM ), which produced A. mortality rates ranging from 38% to 81%. Downregulation the expression in by injection double‐stranded (dsRNA) led muscle structural...
Abstract Background Recently, several studies have investigated the relationship between Pre‐miR‐27a rs895819 polymorphism and risk of various cancers. However, diffuse large B‐cell lymphoma (DLBCL) has not been well known. Methods In this study, we conducted a case‐control study to explore role in DLBCL. The PCR‐TaqMan luciferase assays vitro experiments were used evaluate function. Results As result, found subjects carrying with AG/GG genotype had significantly decreased when compared...
saponins (PNS) have been deemed effective herb compounds for treating ischaemic stroke (IS) and improving the quality of life IS patients. This study aimed to investigate underlying mechanisms PNS in treatment based on network pharmacology.
Pyranones have raised great concerns owing to their considerable applications in a variety of sectors. However, the development direct asymmetric allylation 4-hydroxypyran-2-ones is still restricted. Herein, we present an effective iridium-catalyzed functionalization technique for synthesis 4-hydroxypyran-2-one derivatives over and efficient catalytic Friedel-Crafts-type by using allyl alcohols. The products could be obtained with good high yields (up 96%) excellent enantioselectivities...
The genus Kadsura is a commonly used herb in Chinese folklore, with sedative, hypnotic and beneficial effects, mainly for the treatment of rheumatoid arthritis, insomnia other conditions.Modern pharmacological studies have shown that triterpenoids are one main components to possess these medicinal effects.In addition, also exhibited anti-tumor, cholesterol synthesis inhibition, anti-HIV, antioxidant hepatoprotective activities.At present, there few literatures reported on this...
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Rhizosphere microorganisms are important for maintaining soil and plant health promoting growth development. Screening rhizosphere growth-promoting bacteria with unique habitats, high activity multiple functions is conducive to exploring the potential stress resistance of bacteria, further improving applicability microbial fertilizers in agricultural production response development concept green agriculture. The aim this study was investigate physiological culturable core Dicranopteris...
Eight compounds were isolated from ethyl acetate fraction of 80% ethanol extract the hulls Garcinia mangostana by silica gel, Sephadex LH-20 column chromatography, as well prep-HPLC methods. By HR-ESI-MS, MS, 1D and 2D NMR spectral analyses, structures eight identified 16-en mangostenone E(1), α-mangostin(2), 1,7-dihydroxy-2-(3-methy-lbut-2-enyl)-3-methoxyxanthone(3), cratoxyxanthone(4), 2,6-dimethoxy-para-benzoquinone(5), methyl orselinate(6), ficusol(7),...