A5052943622- Crystallization and Solubility Studies
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Virology and Viral Diseases
- HIV Research and Treatment
- Electrocatalysts for Energy Conversion
- Colorectal Cancer Treatments and Studies
- Crystal structures of chemical compounds
- Immune Cell Function and Interaction
- Analytical Chemistry and Chromatography
- Cytomegalovirus and herpesvirus research
- Telomeres, Telomerase, and Senescence
- Viral Infections and Vectors
- Colorectal Cancer Screening and Detection
- Monoclonal and Polyclonal Antibodies Research
- Nonlinear Optical Materials Research
- vaccines and immunoinformatics approaches
- Parathyroid Disorders and Treatments
- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Cancer Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
Sichuan University
2016-2024
West China Hospital of Sichuan University
2016-2024
Zhejiang Cancer Hospital
2018-2024
Jiamusi University
2016-2024
Libin Cardiovascular Institute of Alberta
2024
University of Calgary
2024
Chinese Academy of Sciences
2020-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2023
Calgary Laboratory Services
2023
Northeast Agricultural University
2021-2023
Abstract In recent years, the emergence of several highly pathogenic zoonotic diseases in humans has led to a renewed emphasis on interconnectedness human, animal, and environmental health, otherwise known as One Health. For example, Hendra virus (HeV), paramyxovirus, was discovered 1994, since then, infections have occurred 7 humans, each whom had strong epidemiologic link similarly affected horses. As consequence these outbreaks, eradication bat populations discussed, despite their crucial...
ABSTRACT Hendra virus (HeV) and Nipah (NiV) are closely related emerging viruses comprising the Henipavirus genus of Paramyxovirinae , which distinguished by their ability to cause fatal disease in both animal human hosts. These infect cells a pH-independent membrane fusion event mediated attachment (G) (F) glycoproteins. Previously, we reported on HeV- NiV-mediated activities detailed host-cell tropism characteristics. studies also suggested that common cell surface receptor, could be...
In the 1990s, Hendra virus and Nipah (NiV), two closely related previously unrecognized paramyxoviruses that cause severe disease death in humans a variety of animals, were discovered Australia Malaysia, respectively. Outbreaks have occurred nearly every year since NiV was first discovered, with case fatality ranging from 10 to 100%. African green monkey (AGM), causes lethal respiratory and/or neurological essentially mirrors fatal human disease. Thus, AGM represents reliable model for...
HIV-1 entry into cells involves formation of a complex between gp120 the viral envelope glycoprotein (Env), receptor (CD4), and coreceptor. For most strains HIV, this coreceptor is CCR5. Here, we provide evidence that CD4 specifically associated with CCR5 in absence or any other receptor-specific ligand. The amount coimmunoprecipitated was significantly higher than major HIV coreceptor, CXCR4, contrast to CXCR4 CD4–CCR5 coimmunoprecipitation not increased by gp120. interaction probably takes...
Hendra virus (HeV) and Nipah (NiV) are closely related emerging viruses comprising the Henipavirus genus of Paramyxovirinae. Each has a broad species tropism can cause disease with high mortality in both animal human hosts. These infect cells by pH-independent membrane fusion event mediated their attachment (G) (F) envelope glycoproteins (Envs). Seven Fabs, m101 to -7, were selected for significant binding soluble form G (sG) which was used as antigen panning large naïve antibody library....
Nipah virus (NiV) is a zoonotic belonging to the henipavirus genus in family Paramyxoviridae. Since NiV was first identified 1999, outbreaks have continued occur humans Bangladesh and India on an almost annual basis with case fatality rates reported between 40% 100%. Ferrets were vaccinated 4, 20 or 100 μg HeVsG formulated human use approved adjuvant, CpG, prime-boost regime. One half of ferrets exposed at days post boost vaccination other 434 vaccination. The presence viral genome assessed...
Background: Nanoparticles exhibit great promise for improving the solubility and tissue-specific distribution of chemotherapeutic agents; however, passive highly variable enhanced permeability retention (EPR) effects observed in tumors frequently leads to insufficient delivery nanodrugs into tumors. The tumor-penetrating peptide iRGD can actively enhance tumor-selective nanoparticles by binding integrin interacting with tissue-penetrating receptor neuropilin-1. Materials methods: To improve...
Hendra virus (HeV) is a zoonotic emerging belonging to the family Paramyxoviridae. HeV causes severe and often fatal respiratory and/or neurologic disease in both animals humans. Currently, there are no licensed vaccines or antiviral drugs approved for human use. A number of animal models have been developed studying infection, with African green monkey (AGM) appearing most faithfully reproduce disease. Here, we assessed utility newly recombinant subunit vaccine based on attachment (G)...
Glyphosate (GLY) is the most widely used broad-spectrum, non-selective herbicide in world, whose main degradation product aminomethyl phosphonic acid (AMPA). Because of long-term and large-scale use, residual GLY AMPA environment pose great environmental human health threats. The purpose this study to evaluate effects mechanism low-concentrations on development zebrafish embryos. Zebrafish embryos were exposed 0, 1, 10, 100, 700 ng·mL-1 for 72 h (from 2 74 post-fertilization). With...
An immunization regimen was evaluated in rabbits consisting of the soluble, oligomeric form envelope glycoprotein HIV-1, strain R2 (gp140 ), or surface component same (Env), gp120 , adjuvant AS02A. The gp140 selected based on its unusual CD4-independent phenotype and exceptionally broad neutralizing response infected donor. immunogen induced antibodies that achieved 50% neutralization 48/48, 80% 43/46 primary strains diverse HIV-1 subtypes tested. tested included members standard panels...
Vancomycin is one of the most commonly used glycopeptide antiobiotics, and as such an important emerging environmental contaminant. Pharmaceuticals personal care products (PPCPs), antibiotics, are problematic since wastewater treatment processes not completely effective at removing these chemical compounds. Since effective, vancomycin occurs in surface water. its metabolites vivo degradation aquatic environment may lead to undesirable ecological effects that threaten or cause reactions...
Chemotherapeutic multidrug resistance (MDR) is the major hindrance for clinical therapy of colorectal cancer (CRC). Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) with selective cytotoxicity might overcome MDR CRC cells. Unfortunately, cross-resistance to TRAIL has been detected in many cells, suggesting need combine sensitizers combat refractory CRC. Our purpose explore potential combination and tumor-cell targeted photodynamic (PDT) combating both chemotherapeutic...
Keel bone damage (KBD) is more prevalent in alternative laying hen housing systems than conventional cages, and its incidence differs from strain to strain. However, the information of KBD Lindian chickens, a native Chinese strain, limited. To investigate effect on fearfulness physiological indicators stress chickens commercial hens, total two hundred 25-wk-old (100 Hy-line Brown 100 chickens) were studied for 7 wk. The birds housed furnished cages with 10 per cage each At 32-wk age, divided...
Hendra virus (HeV) continues to cause morbidity and mortality in both humans horses with a number of sporadic outbreaks. HeV has two structural membrane glycoproteins that mediate the infection host cells: attachment (G) fusion (F) are essential for receptor binding virion-host cell fusion, respectively. N-linked glycosylation viral envelope proteins critical post-translation modifications have been implicated roles integrity, replication evasion immune response. Deciphering glycan...