A5114334302- Influenza Virus Research Studies
- Viral Infections and Vectors
- Virology and Viral Diseases
- Animal Virus Infections Studies
- Pancreatic and Hepatic Oncology Research
- Animal Disease Management and Epidemiology
- Gallbladder and Bile Duct Disorders
- Viral gastroenteritis research and epidemiology
- Ovarian cancer diagnosis and treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Orthopaedic implants and arthroplasty
- Congenital Heart Disease Studies
- Spine and Intervertebral Disc Pathology
- Herpesvirus Infections and Treatments
- Total Knee Arthroplasty Outcomes
- Congenital Diaphragmatic Hernia Studies
- Liver Disease Diagnosis and Treatment
- Immune Response and Inflammation
- Tracheal and airway disorders
- Respiratory viral infections research
- Mosquito-borne diseases and control
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Rheumatoid Arthritis Research and Therapies
- Blood Coagulation and Thrombosis Mechanisms
Japanese Red Cross Medical Center
2013-2025
The Jikei University Hospital
2025
Tochigi Medical Center
2010-2024
National Hospital Organization
2010-2024
Japanese Foundation For Cancer Research
2022-2024
Toho University
2011-2023
Toho University Medical Center Sakura Hospital
2014-2023
Cancer Institute (WIA)
2023
Kagawa University
2017-2023
Jichi Medical University
2022
Abstract In recent years, the emergence of several highly pathogenic zoonotic diseases in humans has led to a renewed emphasis on interconnectedness human, animal, and environmental health, otherwise known as One Health. For example, Hendra virus (HeV), paramyxovirus, was discovered 1994, since then, infections have occurred 7 humans, each whom had strong epidemiologic link similarly affected horses. As consequence these outbreaks, eradication bat populations discussed, despite their crucial...
In 2008, Reston ebolavirus (REBOV) was isolated from pigs during a disease investigation in the Philippines. Porcine reproductive and respiratory syndrome virus (PRRSV) porcine circovirus type 2 (PCV-2) infections were also confirmed affected herds contribution of REBOV to outbreak remains uncertain. We have conducted experimental challenge studies 5-week-old pigs, with exposure animals 10(6) TCID(50) 2008 swine isolate via either oronasal or subcutaneous route. Replication internal organs...
Patients with epithelial ovarian carcinoma upstaged from Stage I/II to IIIC based on lymph node involvement are known have poor prognoses. The authors investigated whether systematic aortic and pelvic lymphadenectomy would affect the prognoses of these patients.During period 1987-1996, 103 patients in I-III underwent optimal cytoreductive surgery at initial surgery. All except for those IA received adjuvant cisplatin-based chemotherapy after Of 67 intraperitoneal tumors limited pelvis, 14...
Although gangliocytic paraganglioma (GP) has generally been regarded as a neuroendocrine tumor, its origin remains unclear. We therefore aimed to investigate the details of this disease by carefully analyzing and extracting common features presented in selected publications.We searched for English Japanese cases GP using PubMed IgakuChuoZasshi databases on August 2010. then extracted sampled raw data from publications performed appropriate statistical analyses. Additionally, we evaluated...
ABSTRACT Hendra virus and Nipah virus, two zoonotic paramyxoviruses in the genus Henipavirus , have recently emerged continue to cause sporadic disease outbreaks humans animals. Mortality rates of up 75% been reported humans, but there are presently no clinically licensed therapeutics for treating henipavirus-induced disease. A recent report indicated that chloroquine, used malaria therapy over 70 years, prevented infection with vitro. Chloroquine was assessed using a ferret model lethal...
We investigated the role of actin microfilaments in nonhost resistance higher plants. Here we present several lines evidence to indicate that are indeed involved blocking fungal penetration Erysiphe pisi, a pathogen pea, normally fails penetrate into plants such as barley, wheat, cucumber and tobacco. When tissues these were treated with cytochalasins, specific inhibitors polymerization, this fungus became able formed haustoria epidermal cells Moreover, treatment various kinds concentrations...
The value of secondary cytoreductive surgery (SCS) for recurrent ovarian cancer is still controversial. aim this study was to clarify candidates SCS. Between January 1987 and September 2000, we performed SCS in 44 patients with cancer, according our selection criteria, disease-free interval (DFI) >6 months, performance status <3, no apparent multiple diseases, age <75 years progressive disease during preoperative chemotherapy, if undertaken. variables were investigated by univariate...
Asian lineage highly pathogenic avian influenza virus (H5N1) continues to cause mortality in poultry and wild bird populations at a panzootic scale. However, little is known about its persistence contaminated tissues derived from infected birds. We investigated feathers detached bodies of ducks evaluate their potential risk for environmental contamination. Four-week-old domestic were inoculated with different clades (H5N1). Feathers, drinking water, feces collected on day 3 postinoculation...
Hendra virus (HeV) infection in humans is characterized by an influenza like illness, which may progress to pneumonia or encephalitis and lead death. The pathogenesis of HeV poorly understood, the lack a mouse model has limited opportunities for pathogenetic research. In this project we reassessed role mice as animal found that are susceptible after intranasal exposure, with aged reliably developing encephalitic disease. We propose anterograde route neuroinvasion brain, possibly along...
We examined feathers of domestic ducks and geese inoculated with 2 different avian influenza virus (H5N1) genotypes. Together isolation from the skin, detection viral antigens ultrastructural observation virions in feather epidermis raise possibility as sources infection.
Objectives. Reactive oxygen species (ROS) are considered to be involved in the pathobiology of rheumatoid arthritis (RA); however, their association with disease activity has not been elucidated. In this study, we measured reactive metabolites (ROM) patients RA using a new Free Radical Analytical System and determined clinical parameters associated ROM. Methods. One hundred fifty-two 80 diabetes mellitus (DM) were included observational study. To measure ROM, d-ROM test was performed on...
Introduction: Hemolymph nodes, characterized by erythrocyte rosettes, are found in humans and animals, including rats. The cytoarchitectural differences they share with lymph nodes the spleen unknown. Herein, we describe cytoarchitecture of rat hemolymph nodes. Methods: We performed immunohistochemical analyses antibodies against CD68, Iba-1, CD3, CD20, S-100. Hematoxylin eosin staining was used to compare findings sections from ordinary spleen. Results: exhibited rosettes macrophages...
Twenty-five 22- to 46-day-old broilers with Newcastle disease (ND) were investigated pathologically and immunohistochemically in order evaluate the mechanism of ND outbreak vaccinated broilers. The live vaccine via drinking water. Clinical signs neurologic respiratory nature. Macroscopically, bursal atrophy, white spots on pancreas, discoloration enlargement kidneys spleen observed Histologically, perivascular cuffing, neuronal degeneration necrosis, glial proliferation present cerebrum,...
Unilateral laminectomy for bilateral decompression (ULBD) lumbar spinal stenosis (LSS) is a less invasive technique compared to conventional laminectomy. Recently, several authors have reported favorable results of low back pain (LBP) in patients LSS treated with ULBD. However, the detailed changes and localization LBP before after ULBD remain unclear. Furthermore, unsymmetrical invasion para-spinal muscle facet joint may result residual symptoms. To clarify these points, we conducted an...
Objective Anamorelin, a novel selective ghrelin receptor agonist, was approved in Japan for the treatment of cachexia pancreatic cancer (PC), albeit with limited evidence. This study evaluated efficacy and safety anamorelin PC examined impact extent weight loss on anamorelin. Methods We retrospectively investigated consecutive patients who received at our institution between June 2021 January 2022. Patients were divided into two groups: moderate-weight-loss group (5-10%) severe-weight-loss...
Pulmonary tumor thrombotic microangiopathy (PTTM) is characterized by widespread fibrocellular intimal proliferation of the small pulmonary arteries and arterioles in patients with metastatic Carcinoma. Microscopic emboll have frequently occurred malignant tumors; however, few cases PTTM been reported. A rare case a patient gastric adenocarcinoma who presented acute dyspnea lethal respiratory failure described. Histologically, diffuse fibromuscular thickening cauring luminal stenosis...