A5100631227- Colorectal Cancer Surgical Treatments
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
- Colorectal and Anal Carcinomas
- Inflammatory Biomarkers in Disease Prognosis
- Brain Metastases and Treatment
- Cancer Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Cancer-related Molecular Pathways
- Colorectal Cancer Screening and Detection
- Advanced Radiotherapy Techniques
- Management of metastatic bone disease
- Drug Transport and Resistance Mechanisms
- Cancer Genomics and Diagnostics
- Nutrition and Health in Aging
- Cancer, Lipids, and Metabolism
- Trace Elements in Health
- Lung Cancer Diagnosis and Treatment
- Cardiac Ischemia and Reperfusion
- Cardiac Imaging and Diagnostics
- Lymphoma Diagnosis and Treatment
- Preterm Birth and Chorioamnionitis
- Chemotherapy-related skin toxicity
- COVID-19 diagnosis using AI
Peking University
2019-2024
Third Affiliated Hospital of Zhengzhou University
2017-2024
Peking University Third Hospital
2019-2024
Zhejiang University
2022
First Affiliated Hospital Zhejiang University
2022
Qamcom Research and Technology (Sweden)
2022
China Aerospace Science and Industry Corporation (China)
2021
Harbin Medical University
2020
First Affiliated Hospital of Fujian Medical University
2020
Fujian Medical University
2020
Objective: To investigate the treatment efficacy of ultra-low-dose bevacizumab for cerebral radiation necrosis. Methods: Patients with necrosis after stereotactic radiotherapy (SRT) confirmed by imaging were included. Bevacizumab (1 mg/kg, once every three weeks, at least continuous treatments) was administered. The primary endpoints included change in symptoms, volume intracranial edema, and changes MRI signals. secondary adverse reactions treatment. Results: In total, 21 patients this...
The area of interpretable deep neural networks has received increased attention in recent years due to the need for transparency various fields, including medicine, healthcare, stock market analysis, compliance with legislation, and law. Layer-wise Relevance Propagation (LRP) Gradient-weighted Class Activation Mapping (Grad-CAM) are two widely used algorithms interpret networks. In this work, we investigated applicability these sensitive application interpreting chest radiography images....
To explore the impact of body composition before neoadjuvant chemoradiotherapy (pre-NCRT) and after (post-NCRT) on complications, survival, tumor response in patients with locally advanced rectal cancer (LARC).Patients LARC who underwent radical surgery NCRT between Ja 22nuary 2012 March 2019 were studied. Body parameters, including skeletal muscle area (SMA), density (MD), visceral fat (VFA), total abdominal (TAFA), subcutaneous (SFA), was identified at third lumbar vertebra level computed...
To investigate the feasibility and early efficacy of 3D-printed vertebral body implantation combined with robotic radiosurgery in treatment spinal tumors. This study included 14 patients tumors from December 2017 to June 2018. Before surgery, all were subjected CT scan 3D data corresponding segments collected. Titanium alloy formed stereotactic radiotherapy performed because risk postoperative residual, high recovery, or recurrence after surgery. The main outcomes remission symptoms,...
Inflammatory response and nutritional status are associated with cancer development progression. The purpose of this study was to explore whether the preoperative fibrinogen-albumin ratio index (FARI) is related prognosis chemoradiotherapy outcome radical surgery after neoadjuvant (NCRT) in patients locally advanced rectal (LARC).In total, 123 LARC who underwent NCRT between June 2012 December 2018 were collected study. Time-dependent receiver operating characteristic (ROC) curve analysis...
Introduction About 50% of patients with non‐small cell lung cancers (NSCLC) are diagnosed brain metastases during treatment, and stereotactic radiosurgery (SRS) is an important treatment for oligometastasis. Some have cerebral edema before radiation therapy may also cause, or aggravate edema. Vascular endothelial growth factor (VEGF) promotes angiogenesis increase vascular permeability, previous studies shown that anti‐VEGF can reduce We hypothesized anlotinib hydrochloride perilesional...
ABSTRACT The aim of this study was to investigate the safety and accuracy computed tomography (CT)-guided 125I seed implantation assisted by a three-dimensional printing non-coplanar template (3D-PNCT) for treating pelvic locally recurrent rectal cancer (LRRC) patients. A total 13 patients with 18 masses received implantation. dosimetric parameters pre-implantation post-implantation were calculated evaluate quality Doses delivered organs at risk (OAR) also calculated. Differences between...
Abstract Background Preoperative tumor markers, inflammation, and nutritional status are considered important predictors of prognosis response in locally advanced rectal cancer (LARC) patients. This study aims to explore the prognostic predictive role carcinoembryonic antigen (CEA), Fibrinogen-Albumin Ratio Index (FARI), Prognostic Nutritional (PNI) LARC patients compared them with a novel combined CEA-FARI-PNI (CFP) scoring system. Methods A total 138 undergoing radical surgery following...
To evaluate the performance of different high-risk human papillomavirus (HR-HPV) genotype models in triaging women with cytological diagnosis atypical squamous cells undetermined significance (ASCUS).A total 36,679 Chinese who underwent cytology and HR-HPV genotyping assessments during cervical cancer screening were enrolled this study. Women cytology-proven ASCUS referred for further by colposcopy biopsy. The study endpoint was histological detection intraepithelial neoplasia grade 2 or...
Abstract Objective To investigate the long‐term safety and efficacy of high‐dose radiotherapy after 3D‐printed vertebral body implantation in treatment spinal tumors. Methods Thirty‐three participants were recruited between July 2017 August 2019. bodies implanted each participant, followed by postoperative robotic stereotactic radiosurgery at a dose 35–40 Gy/5f. The tolerance participant to evaluated. In addition, local control tumor progression‐free survival study following measured as...
Abstract The structure and self‐assembly of the peptide corresponding to third transmembrane domain (TMD3) Slc11a1 its E139A mutant are studied in 1,1,1,3,3,3‐hexafluoro‐2‐propanol (HFIP) aqueous solution by NMR CD experiments. is an integral membrane protein with 12 putative TMDs functions as a pH‐coupled divalent metal cation transporter. Glu139 highly conserved within predicted TMD3 Slc11 family function‐associated. Here, we provide first direct experimental evidence for structural...
Radiation-induced heart damage (RIHD) in malignant tumor patients with thoracic radiotherapy has been well documented. However, there is no study on the cardiac toxicity of stereotactic body (SBRT) based two-dimensional speckle tracking echocardiography (2D STE).In a prospective cohort trial, 48 (including lung cancer, pulmonary metastases and other tumor) were assigned to receive SBRT. Circulating biomarkers, electrocardiogram (ECG), echocardiography, 2D STE performed prior within two...
p53, one of the most well studied tumor suppressor factor, is responsible to a variety damage owing induction apoptosis and cell cycle arrest in cells. More than 50% human tumors contain mutation or deletion p53. Gonadotrophin-releasing hormone (GnRH), as ligand receptor (GnRH-R), was used deliver p53 into The fusion proteins GnRH-p53 GnRH iii-p53 were expressed their targeted anti-tumor effects determined. mediates its transformation cancer intracellular delivery exerted inhibition growth...
The aim of this study was to investigate whether clinical and blood parameters can be used for predicting pathological complete response (pCR) neoadjuvant chemoradiotherapy (nCRT) in patients with locally advanced rectal cancer (LARC). We retrospectively enrolled 226 LARC [allocated a 7:3 ratio training (n = 158) or validation 68) cohort] who received nCRT before radical surgery. Backward stepwise logistic regression performed identify associated achieving pCR. Models based on (CP), (BP),...