To investigate the potential roles that p16 (CDKN2A) and RB activation have in sensitization to MEK inhibitor resistant KRAS-mutant non-small cell lung cancer cells (NSCLC) vitro vivo.Cell viability was measured with MTS assays. Effects of administration radiation combination drug treatments were evaluated by clonogenic assay, flow cytometry, Western blots. DNA repair assessed using immunofluorescent analysis. Finally, xenografts used examine vivo effects treatment therapy.In this study, we...

Background/Aims: Gastric cancer (GC) is an important health problem. Classification based on molecular subtypes may help to determine the prognosis of patients with GC. Tumor invasion and metastasis are factors affecting cancer. We aimed identify genes related tumor metastasis, which serve as indicators good GC prognosis. Methods: tissues adjacent normal were collected from 105 primary who treated by undergoing radical surgery. Samples used for tissue microarray analysis. Identified altered...

Phase II study of whole brain radiotherapy with or without erlotinib in patients multiple metastases from lung adenocarcinoma Hongqing Zhuang,1–4 Zhiyong Yuan,1–4 Jun Wang,1–4 Lujun Zhao,1–4 Qingsong Pang,1–4 Ping Wang1–41Department Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, 2National Clinical Research Center Cancer, 3Tianjin Key Laboratory Prevention Therapy, 4Tianjin Lung Center, Tianjin, People's Republic ChinaAbstract: The aim this paper is to explore the...

Cancer patients are at high risk for suicide, particularly when they informed about the cancer diagnosis or hospitalized treatment. Therefore, oncology healthcare settings such as large general hospitals in China, may represent an ideal setting to identify and treat suicidality patients. However, clinical epidemiology of Chinese remains largely unknown. This study examined prevalence correlates suicidal ideation among inpatients hospitals. A total 517 were consecutively recruited from two...

Abstract Background To investigate the effectiveness and mechanism of 125 I seed continuous low-dose-rate irradiation on colonic cell line CL187 in vitro. Methods The was exposed to radiation 60 Coγ ray at high dose rate 2 Gy/min low 2.77 cGy/h. Radiation responses different doses rates were evaluated by colony-forming assay. Under irradiation, a total 12 culture dishes randomly divided into 4 groups: Control group, 2, 5, 10 Gy groups. At 48 h after apoptosis detected Annexin Propidium...

Abstract: The aim of this study was to evaluate the efficacy and toxicity stereotactic body radiation therapy (SBRT) in treatment patients with liver metastases. Between August 2006 July 2011, 1–4 metastases were enrolled treated SBRT using CyberKnife ® system at Tianjin Medical University Cancer Institute Hospital. from different primary tumors, a maximum tumor diameter less than 6 cm. endpoint local control. Secondary endpoints overall survival, progression-free distant adverse events....

Abstract In order to investigate the efficacy of bevacizumab on treatment radiation cerebral necrosis, patients who were diagnosed with necrosis by imaging after stereotactic radiotherapy collected. Bevacizumab was applied at a dose 5 mg/kg once every three weeks least times. The changes in symptoms before and treatment, edema volume, magnetic resonance (MRI) strengthening phase signals used as first observation point. side effects second Total 14 treated between June 2011 February 2013...

BACKGROUND:Vertebral hemangioma is usually a benign and asymptomatic tumor of blood vessels, but can be aggressive (symptomatic) with expansion, pain, spinal cord compression. The aim this study was to review the effects radiotherapy, surgery, other treatment approaches in patients vertebral hemangioma. MATERIAL AND METHODS:Retrospective clinical included 20 who underwent radiotherapy as their first-line for mild or slowly developing neurological deficit. External radiation divided into...

// Hongqing Zhuang 1 , Yi Zheng 2 Junjie Wang 3 Joe Y. Chang 4 Xiaoguang Zhiyong Yuan Ping Department of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory Prevention Therapy Lung Center, Tianjin, China Daqing Oilfield General Heilongjiang, Peking 3rd Beijing, Radiation Oncology, Division The Texas MD Anderson Houston, TX, USA Correspondence to: Yuan, e-mail: 100_pian@163.com Keywords: brain radiation necrosis,...

To compare plan quality and delivery efficiency of noncoplanar volumetric modulated arc therapy with coplanar therapy, intensity-modulated radiation CyberKnife for multiple brain metastases.For 15 patients metastases, plans a prescription dose 30 Gy in 3 fractions were generated. Noncoplanar consisted 4 arcs 2 full arcs, respectively. Intensity-modulated 7 fields. used skull tracking to ensure accurate position. All generated cover 95% target volume dose. Gradient index, conformity normal...

The optimal administration time for applying epidermal growth factor receptor inhibitors combined with radiotherapy has been unclear. We investigated the efficacy of combining gefitinib radiation in different treatment schedules. demonstrated that was administered to A549 lung cancer cells three ways (administration before irradiation, upon after irradiation) establish radiosensitizing effect. Cell‐survival rates were evaluated by colony‐forming assays. Cell apoptosis and cell‐cycle...

// Huan-Huan Wang 1 , Nicholas G. Zaorsky 2 Mao-Bin Meng Xian-Liang Zeng Lei Deng 3 Yong-Chun Song Hong-Qing Zhuang Feng-Tong Li Lu-Jun Zhao Zhi-Yong Yuan Ping Xi-Shan Hao 4 Department of Radiation Oncology, CyberKnife Center, and Key Laboratory Cancer Prevention Therapy, Tianjin Medical University Institute & Hospital, National Clinical Research Center for Cancer, Tianjin, China Fox Chase Philadelphia, PA, USA Thoracic Huaxi Student Society Oncology Research, West School Medicine, Sichuan...

Acute myeloid leukemia (AML) is not sensitive to chemotherapy partially because of the protection AML cells by mesenchymal stromal (MSCs). Our previous studies found that MSCs protected from apoptosis through c-Myc-dependent pathway. However, mechanism which regulate c-Myc in still unknown. To elucidate mechanism, we performed microRNA array analysis cell lines and validated TaqMan realtime PCR. The results showed expression microRNA-494 (miR-494) after coculture with was downregulated....

Objective: To investigate the treatment efficacy of ultra-low-dose bevacizumab for cerebral radiation necrosis. Methods: Patients with necrosis after stereotactic radiotherapy (SRT) confirmed by imaging were included. Bevacizumab (1 mg/kg, once every three weeks, at least continuous treatments) was administered. The primary endpoints included change in symptoms, volume intracranial edema, and changes MRI signals. secondary adverse reactions treatment. Results: In total, 21 patients this...

To evaluate the efficacy and safety of CyberKnife(®) treatment for locally-advanced pancreatic cancer (LAPC).The was analyzed in 59 LAPC patients treated between October 2006 September 2014. The median tumor volume 27.1 mL (13.0-125.145 mL). prescribed dose 45 Gy (35-50 Gy), delivered 5 fractions (3-8 fractions). overall survival (OS) rates freedom from local progression (FFLP) were estimated using Kaplan-Meier curve.The follow-up all 10.9 months (3.2-48.7 months) 15.6 (3.9-37.6 among...

// Mao-Bin Meng 1,* , Huan-Huan Wang Nicholas G. Zaorsky 2,* Xian-Zhi Zhao 1 Zhi-Qiang Wu Bo Jiang Yong-Chun Song Hong-Qing Zhuang Feng-Tong Li Lu-Jun Chang-Li 3 Kai 4 Ping and Zhi-Yong Yuan Department of Radiation Oncology, CyberKnife Center, Key Laboratory Cancer Prevention Therapy, Tianjin Medical University Institute Hospital, National Clinical Research Center for Cancer, Tianjin, China 2 Fox Chase Philadelphia, PA, USA Lung Thoracic Oncology * These authors have contributed equally to...