A5101503437- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Cardiac and Coronary Surgery Techniques
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Helicobacter pylori-related gastroenterology studies
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Immune Response and Inflammation
- Apelin-related biomedical research
- Medicinal Plants and Bioactive Compounds
- Connective tissue disorders research
- Nuclear Receptors and Signaling
- Pancreatic and Hepatic Oncology Research
- Ovarian cancer diagnosis and treatment
- Fibroblast Growth Factor Research
- Liver physiology and pathology
- Tryptophan and brain disorders
- Genetic factors in colorectal cancer
- Gastroesophageal reflux and treatments
- Macrophage Migration Inhibitory Factor
- NF-κB Signaling Pathways
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- interferon and immune responses
Huashan Hospital
2012-2023
Army Medical University
2012-2022
Daping Hospital
2022
Fudan University
2013-2021
China Pharmaceutical University
2016
Huazhong Agricultural University
2014
DNA modifications such as 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are epigenetic marks known to affect global gene expression in mammals. Given their prevalence the human genome, close correlation with high chemical stability, these could serve ideal biomarkers for cancer diagnosis. Taking advantage of a highly sensitive selective labeling technology, we report here genome-wide profiling 5hmC circulating cell-free (cfDNA) genomic (gDNA) paired tumor adjacent tissues...
Achondroplasia (ACH) and thanatophoric dysplasia (TD) are caused by gain-of-function mutations of fibroblast growth factor receptor 3 (FGFR3) they the most common forms dwarfism lethal dwarfism, respectively. Currently, there few effective treatments for ACH. For neonatal lethality TD patients, no practical therapies available. We here showed that systemic intermittent PTH (1-34) injection can rescue phenotype type II (TDII) mice significantly alleviate retarded skeleton development ACH...
Abstract This study aimed to investigate whether α-fetoprotein (AFP) could affect the malignant behavior of AFP-producing gastric cancer (AFP-GC) and explore relationship between AFP mesenchymal–epithelial transition factor (c-Met) in AFP-GC. In this study, 23 patients with AFP-GC (AFP[+]) 18 common (AFP[−]) were evaluated for c-Met expression using immunohistochemical analysis. The cell line, GCIY, was used. endoribonuclease-prepared small interfering RNA (siRNA) eukaryotic overexpression...
High serum alpha-fetoprotein (AFP) level is a predictor of poor prognosis in patients with gastric cancer (GC). AFP-producing GC (AFP-GC) an aggressive subtype characterized by high incidence liver metastasis and c-Met expression. expression metastasis-associated colon 1 (MACC1), which the transcription activator c-Met, also predicts GC. known to be involved tumor progression into malignant invasive phenotypes. Considering that simultaneously positively correlated AFP MACC1 levels or GC, we...
As a nonspecific antagonist of the adenosine A2A receptor (A2AR), caffeine enhances learning and improves memory impairment. Simultaneously, consumption correlates with feeling anxiety. The hippocampus is functionally differentiated along its dorsal/ventral axis plays crucial role both in Whether exerts regulation by inhibiting A2ARs different subregions still unknown. In present study, we found that after chronic intake drinking water containing (1 g/L, 3 weeks), mice exhibited aggravated...
Abstract DNA modifications such as 5-methylcytosines (5mC) and 5-hydroxymethylcytosines (5hmC) are epigenetic marks known to affect global gene expression in mammals( 1, 2 ). Given their prevalence the human genome, close correlation with expression, high chemical stability, these could serve ideal biomarkers for cancer diagnosis. Taking advantage of a highly sensitive selective labeling technology( 3 ), we report here genome-wide 5hmC profiling circulating cell-free (cfDNA) genomic paired...
Purpose Clinical treatment of gastrointestinal neoplasms in patients with severe coronary stenosis is difficult, and it remains controversial to perform staged or simultaneous surgeries. The purpose this study was retrospectively analyze the feasibility indications for tumor resection off-pump artery bypass (OPCAB) graft surgery. Methods Data collected from a total five patients, including three gastric cancer two colorectal cancer, who underwent radical OPCAB between September 2010 October...
Background Alpha-fetoprotein (AFP)–producing gastric cancer is a distinct type of with high incidence liver metastasis. c-Met considered to play an important role in metastasis cancer. Objective The purpose this study was compare the expression AFP-producing and cancers not producing AFP. Methods We evaluated 23 patients (AFP+) 18 common (AFP–) were for using immunohistochemical analysis. Results 2 groups same (P > 0.05), but AFP+ group had higher strong positive rate than AFP–...
Abstract Background: Clinical treatment of gastrointestinal neoplasms in patients with severe coronary stenosis is difficult, and it remains controversial to perform staged or simultaneous surgeries. The purpose this study was retrospectively analyze the feasibility indications for tumor resection off-pump artery bypass (OPCAB) graft surgery. Methods: Data collected from a total five patients, including three gastric cancer two colorectal cancer, who underwent radical OPCAB between September...
Purpose: Clinical treatment of gastrointestinal neoplasms in patients with severe coronary stenosis is difficult, and it remains controversial to perform staged or simultaneous surgeries. The purpose this study was retrospectively analyze the feasibility indications for tumor resection off-pump artery bypass (OPCAB) graft surgery. Methods: Data collected from a total five patients, including three gastric cancer two colorectal cancer, who underwent radical OPCAB between September 2010...