A5003514739- Catalytic Alkyne Reactions
- Asymmetric Synthesis and Catalysis
- Cancer Genomics and Diagnostics
- Traditional and Medicinal Uses of Annonaceae
- Synthetic Organic Chemistry Methods
- GaN-based semiconductor devices and materials
- Neurobiology and Insect Physiology Research
- RNA modifications and cancer
- Oxidative Organic Chemistry Reactions
- Olfactory and Sensory Function Studies
- Biochemical Analysis and Sensing Techniques
- Epigenetics and DNA Methylation
Fudan University
2017-2025
Givaudan (Switzerland)
2020
State Key Laboratory of Genetic Engineering
2017
DNA modifications such as 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are epigenetic marks known to affect global gene expression in mammals. Given their prevalence the human genome, close correlation with high chemical stability, these could serve ideal biomarkers for cancer diagnosis. Taking advantage of a highly sensitive selective labeling technology, we report here genome-wide profiling 5hmC circulating cell-free (cfDNA) genomic (gDNA) paired tumor adjacent tissues...
Abstract Nowadays, miniaturization, low power consumption and multi‐scenario applications are urgent requirements for the development of next generation vision architecture. Eliminating interface image sensing, memory digital processing units folding entire signal chain into one device has become a promising strategy but remains challenging. Here, 2D fully ferroelectric‐gated negative capacitance (NC) phototransistor is demonstrated to enable integration in‐memory sensing logic processing....
Ultraviolet light-emitting diodes (UV LEDs) play an important role in inactivating novel coronavirus pneumonia, but the lack of rapid lifetime prediction can easily cause untimely failure detection, long product development cycles, and high costs. This study predicts UV LEDs based on short-term memory (LSTM) recurrent neural network (RNN). First, equipment setup was designed to conduct aging test obtain a predicted length life for LED samples using Weibull distribution. Next, LSTM RNN...
A new family of dienone musks was discovered by alkylation different aldehydes with but-3-en-1-yn-1-yllithium and subsequent domino reaction a Saucy–Marbet transfer vinylation–Claisen rearrangement an intramolecular Diels–Alder reaction, concluding Lewis acid catalyzed double-bond isomerization. The newly synthesized structures possess pleasant musk odors displaying fatty, slightly fruity green facets. Although the were predicted in silico to bind OR5AN1 receptor based on QM/MM calculations,...
Abstract A tandem Prins/Friedel‐Crafts cascade strategy has been developed for the synthesis of hexahydro‐2 H ‐benzo[ g ]chromene derivatives. Under action equimolecular amount BF 3 etherate, δ,ϵ‐unsaturated alcohols and arylacetaldehydes are coupled to form oxocarbenium ion intermediates, which captured by alkene moiety through a favored six‐membered transition state. The Prins‐cyclization resultant tertiary carbenium ions undergo consecutive intra molecular Friedel–Crafts cyclization...
We have developed an atom-economical oxovanadate-catalysed cycloisomerization of hydroxy enynes for the synthesis bicyclo[4.3.0]non-1(9)-en-2-ones with cashmeran-like odours.