A5100767491- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Metal-Organic Frameworks: Synthesis and Applications
- Zeolite Catalysis and Synthesis
- Adipose Tissue and Metabolism
- Protein Structure and Dynamics
- Chemical Synthesis and Analysis
- Enzyme Structure and Function
- Metabolism, Diabetes, and Cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Catalysis for Biomass Conversion
- Peroxisome Proliferator-Activated Receptors
- Analytical Chemistry and Chromatography
- Ginseng Biological Effects and Applications
- X-ray Diffraction in Crystallography
- Traditional Chinese Medicine Analysis
- Crystallization and Solubility Studies
- Endoplasmic Reticulum Stress and Disease
- Oxidative Organic Chemistry Reactions
- Acute Myocardial Infarction Research
- Magnetism in coordination complexes
- Alcohol Consumption and Health Effects
- Molecular Sensors and Ion Detection
- Supramolecular Chemistry and Complexes
- Catalytic Processes in Materials Science
Givaudan (Switzerland)
2012-2024
Southwest University
2012-2024
General Hospital of Shenyang Military Region
2024
Shenyang Pharmaceutical University
2024
Xinjiang Medical University
2024
Shanghai Children's Hospital
2020-2024
Shanghai Jiao Tong University
2024
Jiangxi Science and Technology Normal University
2022-2023
China Agricultural University
2020-2023
Fudan University
2003-2022
The binding of the adaptor protein APPL1 to adiponectin receptors is necessary for adiponectin-induced AMP-activated kinase (AMPK) activation in muscle, yet underlying molecular mechanism remains unknown. Here we show that muscle cells and metformin induce AMPK by promoting APPL1-dependent LKB1 cytosolic translocation. mediates signaling directly interacting with enhances localization anchoring this cytosol. Adiponectin also activates another upstream Ca2+/calmodulin-dependent activating...
Impairments in adiponectin multimerization lead to defects secretion and function are associated with diabetes, yet the underlying mechanisms remain largely unknown. We have identified an adiponectin-interacting protein, previously named GST-kappa, by yeast 2-hybrid screening. The protein contains 2 thioredoxin domains has very little sequence similarity other GST isoforms. However, this shares high secondary structure homology bacterial disulfide-bond A oxidoreductase (DsbA) is thus renamed...
Resveratrol (RSV) is a naturally occurring polyphenol that has been found to exert antioxidant, anti-inflammatory, and neuroprotective properties. However, how RSV exerts its beneficial health effects remains largely unknown. Here, we show inhibits insulin- leucine-stimulated mTOR signaling in C2C12 fibroblasts via Sirt1-independent mechanism. Treating cells with dramatically inhibited insulin-stimulated Akt, S6 kinase, 4E-BP1 phosphorylation but had little effect on tyrosine of the insulin...
Binding of insulin receptor substrate proteins 1 and 2 (IRS1/2) to the (IR) is essential for regulation sensitivity energy homeostasis. However, mechanism IRS1/2 recruitment IR remains elusive. Here, we identify adaptor protein APPL1 as a critical molecule that promotes IRS1/2-IR interaction. forms complex with under basal conditions, this then recruited in response or adiponectin stimulation. The interaction between depends on insulin- adiponectin-stimulated phosphorylation, which greatly...
The electrocatalytic nitrate conversion of ammonia at ambient conditions provides not only a solution for restoring the imbalance in global nitrogen cycle but also sustainable alternative Haber-Bosch process. However, large-scale and efficient application denitrification has been limited by lack active catalysts with high selectivity reduction to N2. In this work, we present one-step processed synthetic strategy low temperature prepare carbon-nanobelts-supported uniform Cu Pd nanoclusters....
Endoplasmic reticulum (ER) stress is associated with obesity-induced insulin resistance, yet the underlying mechanisms remain to be fully elucidated. Here we show that ER stress-induced receptor (IR) down-regulation may play a critical role in resistance. The expression levels of IR are negatively marker C/EBP homologous protein (CHOP) target tissues <i>db</i>/<i>db</i> mice and fed high-fat diet. Significant was also observed fat tissue obese human subjects 3T3-L1 adipocytes treated...
OBJECTIVE Obesity impairs adiponectin expression, assembly, and secretion, yet the underlying mechanisms remain elusive. The aims of this study were 1) to determine molecular by which obesity multimerization stability, 2) potential role disulfide-bond-A oxidoreductase-like protein (DsbA-L), a recently identified interactive that promotes stability in obesity-induced endoplasmic reticulum (ER) stress downregulation. RESEARCH DESIGN AND METHODS Tauroursodeoxycholic acid (TUDCA), chemical...
The adaptor protein APPL1 mediates the stimulatory effect of adiponectin on p38 mitogen-activated kinase (MAPK) signaling, yet underlying mechanism remains unclear. Here we show that, in C(2)C(12) cells, overexpression or suppression enhanced suppressed, respectively, adiponectin-stimulated MAPK upstream cascade, consisting transforming growth factor-β-activated 1 (TAK1) and 3 (MKK3). In vitro affinity binding coimmunoprecipitation experiments revealed that TAK1 MKK3 bind to different...
The antidiabetic and antiatherosclerotic effects of adiponectin make it a desirable drug target for the treatment metabolic cardiovascular diseases. However, adiponectin-based development approach turns out to be difficult due extremely high serum levels this adipokine. On other hand, significant correlation between multimerization its insulin-sensitizing has been demonstrated, suggesting promising alternative therapeutic strategy. Here we show that transgenic mice overexpressing disulfide...
We recently found that the adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and leucine zipper motif (APPL)1 is essential for mediating adiponectin signal to induce liver kinase B (LKB)1 cytosloic translocation, an step activation of AMP-activated (AMPK) in cells. However, underlying molecular mechanisms remain unknown. Here, we demonstrate treating C2C12 myotubes with promoted APPL1 interaction phosphatase 2A (PP2A) Cζ (PKCζ), leading PP2A subsequent...
Abstract Phosphonothioates, phosphinothioates and phosphorothioates are regarded as an important class of sulfur‐containing organophosphorus compounds. Because the unique P(O)S−R group, these compounds have biological activities thus been widely used in fields pharmaceuticals pesticides. In recent years, development by radical processes has attracted considerable attention chemistry. Along lines, this review, advances synthesis were systematically summarized. According to different ways...
Accumulating evidence strongly suggests that autophagy, which is induced by endoplasmic reticulum (ER) stress in adipocytes, may play an important role obesity-induced insulin resistance and type 2 diabetes. Obesity induces ER mouse adipose tissue, correlates with reduced adiponectin levels. In 3T3-L1 induction of sufficient to promote autophagy-dependent degradation. contrast, suppressing increases levels adipocytes alleviates high fat diet-induced downregulation mice. The stress-induced...
Two novel metal−organic frameworks (MOFs) of Co(II), {[Co(bpdc)(bpdap)]·1.5H2O}n (1) and [Co(bpdc)(Hpb)(H2O)]n (2) (bpdap = N,N'-bis(2-pyridyl)-2,6-diaminopyridine, H2bpdc biphenyl-4,4'-dicarboxylic acid, Hpb 2-(2-pyridyl)-benzimidazole), have been synthesized by a hydrothermal method structurally characterized. The structure determination reveals that both 1 2 crystallize in triclinic system, space group P1̄. Complex has 1D zigzag chain where Co(II) is bridged bpdc alternate...
Defects in insulin secretion and reduction β-cell mass are associated with type 2 diabetes humans, understanding the basis for these dysfunctions may reveal strategies therapy. In this study, we show that pancreas-specific knockout of growth factor receptor-binding protein 10 (Grb10), which is highly expressed pancreas islets, leads to elevated insulin/IGF-1 signaling enhanced content, increased mice. Pancreas-specific disruption Grb10 expression also improved glucose tolerance mice fed a...
This study investigates the role of glycogenolysis in stimulated release ATP as a transmitter from astrocytes. Within last 20 years our understanding brain has changed it being relatively uninteresting process to driving force for essential functions like production glutamate and homoeostasis potassium ions (K + ) after their excited neurons. Simultaneously, importance astrocytic handling adenosine, its phosphorylation some ATP, located vesicles, an important also become be realized. Among...
Background Phytochemical-mediated alterations in P-glycoprotein (P-gp) activity may result herb-drug interactions by altering drug pharmacokinetics. Shengmai-san, a traditional Chinese herbal medicine composed Panax Ginseng, Ophiopogon Japonicus, and Schisandra Chinensis, is routinely being used for treating various coronary heart diseases. In our previous studies, Lignans Extract (SLE) was proved as strong P-gp inhibitor, herein, the compatibility of Shengmai-san studied investigating...
The use of intense anticoagulation and antiplatelet therapy in acute myocardial infarction (AMI) potentially increases the risk bleeding complications during percutaneous coronary intervention (PCI) via transfemoral approach. Recently, transradial access has been increasingly employed as an alternative means for diagnostic interventional procedures. Low incidence vascular site suggests approach a safe to femoral technique AMI, particularly under aggressive anticoagulation/antiplatelet...
In the presence of a Lewis acid, β,γ-unsaturated ketones and oximes or imines undergo nucleophilic addition to produce zwitterion intermediates, subsequent oxy-2-azonia-Cope rearrangements give homoallylic amides. case 2-vinylcycloalkanones, process results in ring enlargement, providing novel route 9- 16-membered lactams. The preparative significance this protocol was evidenced by short synthesis macrocyclic alkaloid motuporamine G. stereochemistry-defining step oxy-azonia-Cope...