A5007631869- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Head and Neck Cancer Studies
- Endoplasmic Reticulum Stress and Disease
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Autophagy in Disease and Therapy
- Immune Cell Function and Interaction
- Metabolism, Diabetes, and Cancer
- IL-33, ST2, and ILC Pathways
- Sirtuins and Resveratrol in Medicine
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic function and diabetes
- Head and Neck Surgical Oncology
- Exercise and Physiological Responses
- Cancer Mechanisms and Therapy
- Estrogen and related hormone effects
- RNA modifications and cancer
- Melanoma and MAPK Pathways
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- PI3K/AKT/mTOR signaling in cancer
- Lipid metabolism and biosynthesis
University of New Mexico
2016-2025
Guangdong Medical College
2015-2024
Guilin University of Electronic Technology
2023-2024
Affiliated Hospital of Guangdong Medical College Hospital
2023
Guilin Medical University
2011-2022
Second Xiangya Hospital of Central South University
2013-2022
Central South University
2008-2022
Affiliated Hospital of Guilin Medical College
2011-2022
Children’s Hospital of Fudan University Xiamen Branch
2021
Chinese Institute for Brain Research
2020
Significance Activation of the cGAMP-cGAS-STING pathway has recently been shown to mediate virus- or bacteria-induced activation innate immune response. Here we report that this also plays an important role in obesity-induced inflammation and metabolic dysfunction, beyond its well-characterized roles surveillance. We have identified adipose disulfide-bond A oxidoreductase-like protein as a key regulator mitochondrial integrity function, which protects mice from insulin resistance by...
The endoplasmic reticulum (ER) engages mitochondria at specialized ER domains known as mitochondria-associated membranes (MAMs). Here, we used three-dimensional high-resolution imaging to investigate the formation of pleomorphic "megamitochondria" with altered MAMs in brown adipocytes lacking Sel1L-Hrd1 protein complex ER-associated degradation (ERAD). Mice ERAD deficiency were cold sensitive and exhibited mitochondrial dysfunction. affected ER-mitochondria contacts dynamics, least part, by...
Adiponectin functions as an insulin sensitizer, and yet the underlying molecular mechanism(s) remains largely unknown. We found that treating C2C12 myotubes with adiponectin or rapamycin enhanced ability of to stimulate IRS-1 tyrosine phosphorylation Akt phosphorylation, concurrently reduced p70 S6 kinase at Thr389 well Ser302 Ser636/639. Overexpression dominant-negative AMP (AMPK), but not p38 MAPK, insulin-sensitizing effect adiponectin. Rapamycin, adiponectin, insulin-stimulated in HeLa...
Impairments in adiponectin multimerization lead to defects secretion and function are associated with diabetes, yet the underlying mechanisms remain largely unknown. We have identified an adiponectin-interacting protein, previously named GST-kappa, by yeast 2-hybrid screening. The protein contains 2 thioredoxin domains has very little sequence similarity other GST isoforms. However, this shares high secondary structure homology bacterial disulfide-bond A oxidoreductase (DsbA) is thus renamed...
Resveratrol (RSV) is a naturally occurring polyphenol that has been found to exert antioxidant, anti-inflammatory, and neuroprotective properties. However, how RSV exerts its beneficial health effects remains largely unknown. Here, we show inhibits insulin- leucine-stimulated mTOR signaling in C2C12 fibroblasts via Sirt1-independent mechanism. Treating cells with dramatically inhibited insulin-stimulated Akt, S6 kinase, 4E-BP1 phosphorylation but had little effect on tyrosine of the insulin...
Depression is a debilitating mental illness and often comorbid with metabolic disorders such as type 2 diabetes. Adiponectin an adipocyte–derived hormone antidiabetic insulin-sensitizing properties. Here we show that adiponectin levels in plasma are reduced chronic social-defeat stress model of depression, which correlates decreased social interaction time. A reduction caused by haploinsufficiency results increased susceptibility to aversion, “anhedonia,” learned helplessness causes impaired...
Human obesity has become a global health epidemic, with few safe and effective pharmacological therapies currently available. The systemic loss of ovarian estradiol (E2) in women after menopause greatly increases the risk metabolic dysfunction, revealing critical role E2 this setting. salutary effects are traditionally attributed to classical estrogen receptors ERα ERβ, contribution G protein-coupled receptor (GPER) still largely unknown. Here, we used ovariectomy- diet-induced (DIO) mouse...
Obesity is a global epidemic that caused by excessive energy intake or inefficient expenditure. Brown beige fat dissipates as heat through non-shivering thermogenesis their high density of mitochondria. However, how the mitochondrial stress-induced signal coupled to cellular thermogenic program remains elusive. Here, we show DNA escape-induced activation cGAS-STING pathway negatively regulates in fat-specific DsbA-L knockout mice, model adipose tissue stress. Conversely, overexpression STING...
Endoplasmic reticulum (ER) stress is associated with obesity-induced insulin resistance, yet the underlying mechanisms remain to be fully elucidated. Here we show that ER stress-induced receptor (IR) down-regulation may play a critical role in resistance. The expression levels of IR are negatively marker C/EBP homologous protein (CHOP) target tissues <i>db</i>/<i>db</i> mice and fed high-fat diet. Significant was also observed fat tissue obese human subjects 3T3-L1 adipocytes treated...
OBJECTIVE Obesity impairs adiponectin expression, assembly, and secretion, yet the underlying mechanisms remain elusive. The aims of this study were 1) to determine molecular by which obesity multimerization stability, 2) potential role disulfide-bond-A oxidoreductase-like protein (DsbA-L), a recently identified interactive that promotes stability in obesity-induced endoplasmic reticulum (ER) stress downregulation. RESEARCH DESIGN AND METHODS Tauroursodeoxycholic acid (TUDCA), chemical...
The natural polyphenol resveratrol (RSV) displays a wide spectrum of health beneficial activities, yet the precise mechanisms remain to be fully elucidated. Here we show that RSV promotes multimerization and cellular levels adiponectin in 3T3-L1 adipocytes. stimulatory effect was not affected by knocking out Sirt1, but diminished suppressing expression DsbA-L, recently identified adiponectin-interactive protein multimerization. Suppression Akt signaling pathway resulted an increase DsbA-L...
Group 2 innate lymphoid cells (ILC2s) in white adipose tissue (WAT) promote WAT browning and assist preventing the development of obesity. However, how ILC2 is regulated remains largely unknown. Here, our study shows that ILC2s are present brown (BAT) as well subcutaneous epididymal (sWAT eWAT). The fractions ILC2s, natural killer T (NKT) eosinophils sWAT, eWAT BAT significantly decreased by high-fat-diet (HFD) feeding leptin deficiency-induced Consistent with this, expression circulating...
Cancer cells are characterized by a pathological manifestation of uncontrolled proliferation, which results in tumor formation. Therefore, it is necessary to improve understanding the underlying mechanism cell cycle control. Here, we report that miR‑150 downregulated nasopharyngeal carcinoma tissues and cells. Upregulation suppresses (NPC) proliferation induces G1/S arrest vitro, inhibits tumorigenesis vivo. Conversely, silencing yields opposite effect. Our further demonstrate retards...
Allergic asthma and obesity are the leading health problems in world. Many studies have shown that is a risk factor of development asthma. However, underlying mechanism has not been well established. In this study, we demonstrate leptin, an adipokine elevated obese individuals, promoted proliferation survival pro-allergic type 2 helper T cells group innate lymphoid production cytokines, which together contribute to allergic responses. Leptin activates mTORC1, MAPK, STAT3 pathways TH2 cells....
Highlights•mTORC1 is a potent regulator of white to beige adipogenesis•mTORC1 inhibition leads WAT browning and occurs despite sympathetic denervation•COX-2 prostaglandins are essential for in Raptor-deficient mice•mTORC1 suppresses COX-2/PG pathway via CRTC2-dependent mechanismSummaryBeige adipocytes present adipose tissue (WAT) have thermogenic capacity orchestrate substantial energy metabolism counteract obesity. However, adipocyte-derived signals that act on progenitor cells control...
The antidiabetic and antiatherosclerotic effects of adiponectin make it a desirable drug target for the treatment metabolic cardiovascular diseases. However, adiponectin-based development approach turns out to be difficult due extremely high serum levels this adipokine. On other hand, significant correlation between multimerization its insulin-sensitizing has been demonstrated, suggesting promising alternative therapeutic strategy. Here we show that transgenic mice overexpressing disulfide...