A5007974064- Monoclonal and Polyclonal Antibodies Research
- Cell Adhesion Molecules Research
- Glycosylation and Glycoproteins Research
- Peptidase Inhibition and Analysis
- RNA Interference and Gene Delivery
- Angiogenesis and VEGF in Cancer
- Advanced Biosensing Techniques and Applications
- Virus-based gene therapy research
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Immunotherapy and Immune Responses
- Neuroblastoma Research and Treatments
- Cancer Research and Treatments
- CAR-T cell therapy research
- Cytokine Signaling Pathways and Interactions
- Adipose Tissue and Metabolism
- Chemical Synthesis and Analysis
- Prostate Cancer Treatment and Research
- Nanoplatforms for cancer theranostics
- Protease and Inhibitor Mechanisms
- Advanced Proteomics Techniques and Applications
- Ubiquitin and proteasome pathways
- Axon Guidance and Neuronal Signaling
- SARS-CoV-2 and COVID-19 Research
- Cancer, Hypoxia, and Metabolism
Rutgers, The State University of New Jersey
2018-2025
Rutgers New Jersey Medical School
2018-2025
Rutgers Cancer Institute of New Jersey
2018-2024
The University of Texas MD Anderson Cancer Center
2008-2023
Rutgers Sexual and Reproductive Health and Rights
2021-2022
Newark Hospital
2021
University Hospital, Newark
2018-2020
New Mexico Cancer Center
2014-2017
University of New Mexico
2014-2017
UNM Comprehensive Cancer Center
2014-2017
In vivo selection of phage display libraries was used to isolate peptides that home specifically tumor blood vessels. When coupled the anticancer drug doxorubicin, two these peptides-one containing an alphav integrin-binding Arg-Gly-Asp motif and other Asn-Gly-Arg motif-enhanced efficacy against human breast cancer xenografts in nude mice also reduced its toxicity. These results indicate it may be possible develop targeted chemotherapy strategies are based on selective expression receptors...
It has been shown that stromal–vascular fraction isolated from adipose tissues contains an abundance of CD34 + cells. Histological analysis tissue revealed cells are widely distributed among adipocytes and predominantly associated with vascular structures. The majority freshly were CD31 − /CD144 could be separated a distinct population /CD31 (endothelial) by differential attachment on uncoated plastic. localization within suggested the nonendothelial these occupied pericytic position....
Vascular beds are known to differ in structure and metabolic function, but less is about their molecular diversity. We have studied organ-specific differences of the endothelium various tissues by using vivo screening peptide libraries expressed on surface a bacteriophage. report here that targeting large number with this method yielded, each case, phage homed selectively targeted organ. Different motifs were recovered from these tissues. The enrichment homing target organs relative an...
Daptomycin is a lipopeptide with bactericidal activity that acts on the cell membrane of enterococci and often used off-label to treat patients infected vancomycin-resistant enterococci. However, emergence resistance daptomycin during therapy threatens its usefulness.We performed whole-genome sequencing characterization envelope clinical pair Enterococcus faecalis isolates from blood patient fatal bacteremia; one isolate (S613) was drawn before treatment other (R712) after daptomycin. The...
Abstract The connection between obesity and accelerated cancer progression has been established, but the mediating mechanisms are not well understood. We have shown that stromal cells from white adipose tissue (WAT) cooperate with endothelium to promote blood vessel formation through secretion of soluble trophic factors. Here, we hypothesize WAT directly mediates by serving as a source migrate tumors neovascularization. To test this hypothesis, evaluated recruitment WAT-derived effect their...
Prostate cancer antigen 3 (PCA3) is the most specific prostate biomarker but its function remains unknown. Here we identify PRUNE2, a target protein-coding gene variant, which harbors PCA3 locus, thereby classifying as an antisense intronic long noncoding (lnc)RNA. We show that controls PRUNE2 levels via unique regulatory mechanism involving formation of PRUNE2/PCA3 double-stranded RNA undergoes adenosine deaminase acting on (ADAR)-dependent adenosine-to-inosine editing. expression or...
Organ specific drug targeting was explored in mice as a possible alternative to surgery treat prostate diseases. Peptides that specifically recognize the vasculature were identified from phage-displayed peptide libraries by selecting for phage capable of homing into after an i.v. injection. One selected this manner homed 10–15 times more than other organs. Unselected did not show preference. The bound also human prostate. displayed prostate-homing phage, SMSIARL (single letter code),...