A5101776327- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Viral Infections and Immunology Research
- Cardiac Ischemia and Reperfusion
- NF-κB Signaling Pathways
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Cardiac Arrest and Resuscitation
- Neurotransmitter Receptor Influence on Behavior
- Tea Polyphenols and Effects
- Liver Diseases and Immunity
- Biochemical Analysis and Sensing Techniques
- Cardiac Arrhythmias and Treatments
- Plant Gene Expression Analysis
- Circular RNAs in diseases
- Immune Response and Inflammation
- Regulation of Appetite and Obesity
- Cardiovascular Disease and Adiposity
- MicroRNA in disease regulation
- Cardiovascular Health and Disease Prevention
- Adrenal Hormones and Disorders
- Pulmonary Hypertension Research and Treatments
- Cell Adhesion Molecules Research
Shaanxi University of Chinese Medicine
2024
Harbin Medical University
2006-2019
First Affiliated Hospital of Harbin Medical University
2006-2019
Daqing City People's Hospital
2007
Tea is a popular beverage with characteristic functional and flavor qualities, known to be rich in bioactive metabolites such as tea polyphenols theanine. Recently, varieties variations leaf color have been widely used agriculture production due their potential advantages terms of quality. Numerous studies genome, transcriptome, metabolome, proteome, lipidome methods uncover the causes investigate impacts on accumulation crucial plants. Through comprehensive review various omics...
The activation of Toll-like receptors (TLRs) leads to proinflammatory cytokine production, which is responsible for activating the innate immune system. Thus, TLR signaling subject multilayer regulatory control mechanisms that aim prevent a protective response from causing injury. In present study, we report E3 ubiquitin ligase RNF182 highly expressed in macrophages and specifically upregulated by stimuli (TLR4, TLR3 TLR9 agonists). Knockdown selectively amplifies promoting production...
The use of intense anticoagulation and antiplatelet therapy in acute myocardial infarction (AMI) potentially increases the risk bleeding complications during percutaneous coronary intervention (PCI) via transfemoral approach. Recently, transradial access has been increasingly employed as an alternative means for diagnostic interventional procedures. Low incidence vascular site suggests approach a safe to femoral technique AMI, particularly under aggressive anticoagulation/antiplatelet...
Summary The aim of the present study was to investigate whether combination acute or chronic atorvastatin treatment with ischaemic post‐conditioning ( IP ost) exerts differential effects within hearts diabetic and non‐diabetic rats. Diabetic rats were randomly assigned one six groups: (i) a non‐conditioned group; (ii) group subjected ost; (iii) statin (50 μmol/L during reperfusion) without (iv) plus (v) (10 mg/kg per day for 2 weeks) (vi) ost. from in each 30 min global ischaemia, followed...
Although the aetiology of idiopathic dilated cardiomyopathy (IDC) remains unclear, many immunological abnormalities involving changes in cell-mediated and humoral immunity may be associated with cardiac impairment IDC. Autoimmune mechanisms are likely to participate pathogenesis at least a subgroup IDC components major histocompatibility complex serve as markers for propensity develop immune-mediated myocardial damage. Human leukocyte antigen (HLA) class II genes, which highly polymorphic,...
As one important constituent extracted from a traditional Chinese medicine, Uncaria rhynchophylla Miq Jacks, isorhynchophylline has been used to treat hypertension, epilepsy, headache, and other illnesses. Whether protects hearts against cardiac arrhythmias is still incompletely investigated. This study was therefore aimed examine the preventive effects of on heart in guinea pigs rats then explore their electrophysiological mechanisms. In vivo, ouabain calcium chloride were establish...
Myocardial reperfusion therapy remains the most effective strategy to limit infarct size and improve clinical outcome. However, injury is still inevitable, a number of strategies have been developed ameliorate its lethal The beneficial roles ischemic postconditioning (Ipost) regained more interest in targeting myocardial phase cardioprotection.This study was determine whether acute or chronic treatment with atorvastatin affects cardioprotection when it combined Ipost.Acute significantly...
We investigated the effects of neuroendocrine modulator hydrocortisone (HC) on Th2 differentiation human naive CD4+ T cells with and without CD28 co-stimulation. Human were isolated purified from umbilical cord blood mononuclear full-term newborn infants. treated different concentrations HC under Th0 or culture conditions. conditions included stimulation by immobilized monoclonal antibodies (mAbs) against CD3 CD28; same + rhIL-4. Parallel cultures excluded mAb. Th1 (IL-2, INF-γ)- (IL-4,...
Experimental autoimmune myocarditis (EAM) in rats is a T-cell-mediated disorder. The initiation and maintenance of responses EAM depend on the maturation state dendritic cells. IL-10 pleiotrophic immunomodulatory cytokine that functions at different levels immune response, so it has emerged as promising therapeutic factor for treatment autoimmune/inflammatory diseases. This study was designed to test hypothesis gene modified bone marrow-derived immature cells (iDCs) ameliorate explore...
Aging-associated dysfunction of the immune system contributes to increase in pathophysiological processes that occur with age. Numerous studies have shown microRNAs regulate responses, although their role age-related macrophage remains elusive. Here, we found miR-350-3p is expressed at lower levels peritoneal macrophages from aged mice compared young mice, and lipopolysaccharide (LPS) stimulation downregulates expression a greater extent macrophages. Consequently, LPS-stimulated express more...
Summary Introduction Atrial fibrillation ( AF ) is the most common cardiac arrhythmia. However, current drug interference of antiarrhythmia has limited efficacy and off‐target effects. Accumulating evidence implicated a potential role nitration stress in pathogenesis . The aim study was to determine whether TPEN provided antinitration effects on atrial myocytes during , especially under circumstances stress. Methods We utilized rapid paced HL ‐1 cells model for changes electrophysiological...
We aimed at observing the effects of high thoracic epidural anesthesia (HTEA) on cardiac structure and function, heart rate variability (HRV), QT interval variation (QTV) in ischemic cardiomyopathy (ICM) patients with chronic failure.We divided 30 ICM into HTEA (N = 16) control 14) groups.The group was treated medication, medication for 4 weeks.We measured changes left-ventricular end-diastolic diameter (LVEDd) ejection fraction (LVEF) before after treatment by using echocardiography...