A5047614864- Plant Molecular Biology Research
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
- Plant nutrient uptake and metabolism
- RNA modifications and cancer
- Cancer-related gene regulation
- Autophagy in Disease and Therapy
- Histone Deacetylase Inhibitors Research
- Light effects on plants
- Receptor Mechanisms and Signaling
- Peptidase Inhibition and Analysis
- Photosynthetic Processes and Mechanisms
- Corneal surgery and disorders
- Personality Disorders and Psychopathology
- interferon and immune responses
- Immune Cell Function and Interaction
- PI3K/AKT/mTOR signaling in cancer
- Plant Stress Responses and Tolerance
- Ophthalmology and Visual Impairment Studies
- Shoulder Injury and Treatment
- Psychotherapy Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Drug-Induced Adverse Reactions
- Biochemical Analysis and Sensing Techniques
Icahn School of Medicine at Mount Sinai
2016-2025
Fujian Agriculture and Forestry University
2017-2025
Zhongnan Hospital of Wuhan University
2009-2025
Tisch Hospital
2021-2025
Tisch Cancer Institute
2025
Wuhan University
2009-2025
Cancer Institute (WIA)
2025
Pharmac
2024
Southwest Petroleum University
2023-2024
Sichuan University
2015-2024
Abstract Upon encountering oxidative stress, proteins are oxidized extensively by highly reactive and toxic species, these damaged, need to be degraded rapidly effectively. There two major proteolytic systems for bulk degradation in eukaryotes, the proteasome vacuolar autophagy. In mammalian cells, 20S a specific type of autophagy, chaperone-mediated involved mild stress. However, little is known about how cells remove when under severe Using macroautophagy markers, monodansylcadaverine...
Autophagy is a protein degradation process in which cells recycle cytoplasmic contents when subjected to environmental stress conditions or during certain stages of development. Upon the induction autophagy, double membrane autophagosome forms around components and delivers them vacuole lysosome for degradation. In plants, autophagy has been shown previously be induced abiotic stresses including nutrient starvation oxidative stress. this paper, we demonstrate high salt osmotic conditions,...
Summary Vacuolar autophagy is a major pathway by which eukaryotic cells degrade macromolecules, either to remove damaged or unnecessary proteins, produce respiratory substrates and raw materials survive periods of nutrient deficiency. During autophagy, double membrane forms around cytoplasmic components generate an autophagosome, transported the vacuole. The outer fuses with vacuole lysosome, inner its contents are degraded vacuolar lysosomal hydrolases. We have identified small gene family...
Significance The modulation of growth and development is central to sessile plants. Shoot root meristems share almost identical molecular machineries but are responsible for different types aboveground underground organogenesis. How two such highly similar biological systems respond environmental cues regulate distinct developmental programs remains largely unknown. We report that, in harmony with nature, the shoot, not root, demands light activation cell proliferation during decipher...
Among epigenetic "writers", "readers", and "erasers", the lysine methyltransferases G9a GLP, which catalyze mono- dimethylation of histone H3 9 (H3K9me2) nonhistone proteins, have been implicated in a variety human diseases. A "toolkit" well-characterized chemical probes will allow biological disease hypotheses concerning these proteins to be tested cell-based animal models with high confidence. We previously discovered potent selective G9a/GLP inhibitors including cellular probe UNC0638,...
Chemogenetic tools such as designer receptors exclusively activated by drugs (DREADDs) are routinely used to modulate neuronal and non-neuronal signaling activity in a relatively noninvasive manner. The first generation of DREADDs were templated from the human muscarinic acetylcholine receptor family insensitive endogenous agonist but instead clozapine-N-oxide (CNO). Despite undisputed success CNO an activator DREADDs, it has been known for some time that is subject low rate metabolic...
Proteolysis Targeting Chimeras (PROTACs) are attractive therapeutic modalities for degrading disease-causing proteins. While many PROTACs have been developed numerous protein targets, current small-molecule PROTAC approaches cannot target undruggable proteins that do not binders. Here, we present a novel approach, termed bridged PROTAC, which utilizes binder of the protein's binding partner to recruit complex into close proximity with an E3 ubiquitin ligase Applying this strategy, discovered...
Summary Autophagy is a process that thought to occur in all eukaryotes which cells recycle cytoplasmic contents when subjected environmental stress conditions or during certain stages of development. Upon induction autophagy, double membrane‐bound structures called autophagosomes engulf portions the cytoplasm and transfer them vacuole lysosome for degradation. In this study, we have characterized two potential markers autophagy plants, fluorescent dye monodansylcadaverine (MDC) green protein...
Background: The present study investigated the prevalence of refractive error, visual impairment, and eye diseases in school-aged children western China.Methods: survey was done a representative county (Yongchuan District, Chongqing Municipality) China. Cluster random sampling used to select aged 6 15 years. We conducted door-to-door surveys examinations including optometry, stereoscopic vision test, position movement, slit lamp examination anterior segment, retinoscopy, fundus after...
Significance Development in multicellular organisms consists of a series cell divisions followed by expansions, which are tightly controlled both spatially and temporally. Disorganized division causes serious growth defects animals plants. Auxin has been repeatedly implicated regulating patterns during organogenesis plants; however, the underlying mechanisms remain to be further investigated. Here, we demonstrate that auxin signaling controls pattern activating Mitogen-Activated Protein...
Significance Light enhances the translation efficiency of thousands mRNAs during photomorphogenic development in Arabidopsis , but underlying molecular mechanism remains elusive. Here we show that light activates auxin-target rapamycin (TOR)-ribosome protein S6 (RPS6) pathway to enhance deetiolating . We discovered CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) represses TOR activity dark-grown seedlings. The perception far-red and blue by photoreceptors inactivates COP1, which leads derepression...