A5053429222- Global Health Care Issues
- Global Maternal and Child Health
- Health disparities and outcomes
- Global Public Health Policies and Epidemiology
- Climate Change and Health Impacts
- Chronic Obstructive Pulmonary Disease (COPD) Research
- High Altitude and Hypoxia
- Healthcare Systems and Reforms
- Global Cancer Incidence and Screening
- Asthma and respiratory diseases
- Child Nutrition and Water Access
- Health Systems, Economic Evaluations, Quality of Life
- Air Quality and Health Impacts
- Neonatal Respiratory Health Research
- Fibroblast Growth Factor Research
- Neuroscience of respiration and sleep
- Multiple and Secondary Primary Cancers
- Respiratory viral infections research
- Lung Cancer Diagnosis and Treatment
- Respiratory Support and Mechanisms
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Atrial Fibrillation Management and Outcomes
- Lung Cancer Treatments and Mutations
- Insurance, Mortality, Demography, Risk Management
Fudan University
2016-2025
Zhongshan Hospital
2016-2025
Xi'an Jiaotong University
2008-2024
The First Affiliated Hospital, Sun Yat-sen University
2009-2021
Sun Yat-sen University
2009-2021
University of Washington
2016-2019
Institute for Health Metrics and Evaluation
2016-2019
Auckland University of Technology
2018-2019
University of Groningen
2018
Seattle University
2017
Abstract Autophagy, a type II programmed cell death, is essential for survival under stress, e.g . lung injury, and bone marrow‐derived mesenchymal stem cells ( BM ‐ MSC s) have great potential therapy. However, the mechanisms underlying activation of autophagy to provide therapeutic effect in ischaemia/reperfusion‐induced injury IRI ) remain unclear. Thus, we investigate following transplantation with s. Seventy mice were pre‐treated s before they underwent surgery vivo Human pulmonary...
Side population (SP) cells can be used to identify putative cancer stem (CSC), but this technique is hampered by the requirement for an ultraviolet (UV) laser source. DyeCycle Violet reagent (DCV) a DNA-binding dye that in common violet diode (VLD)-equipped flow cytometer. In paper, we analyzed SP from several bladder cell lines using either Hoechst 33342 or DCV staining. The 33342-stained were identified with UV-equipped cytometer, while DCV-stained VLD-equipped staining was also sort and...
An important precursor to lung cancer development is chronic obstructive pulmonary disease (COPD), independent of exposure tobacco smoke. Both diseases are associated with increased host susceptibility, inflammation, and genomic instability. However, validation the candidate genes functional confirmation test shared genetic contribution cellular mechanisms in patients COPD remains underexplored. Here, we show that loss PARK2 (encoding Parkin) increases expression proinflammation factors as...
Inflammatory responses are considered to be the critical mechanism underlying particulate matter (PM)-induced development and exacerbation of chronic respiratory diseases. MiR-29b-3p has been found participate in various biological processes, but its role PM-induced inflammatory was previously unknown. Here, we constructed a miRNA PCR array find that miR-29b-3p most highly expressed human bronchial epithelial cells (HBECs) exposed PM. promoted pro-inflammatory cytokines (IL-1β, IL-6, IL-8)...
To investigate the characteristics and survival of lung cancer patients with additional malignant primary cancers.
The clinical value of shotgun metagenomic next-generation sequencing (mNGS) in improving the detection rates respiratory pathogens is well-established. However, mNGS complex and expensive. This study designed evaluated performance targeted NGS (tNGS) diagnosing infections. We retrospectively included samples from 281 patients with lower tract infections to establish thresholds pathogens. Subsequently, target were selected a probe hybridization system was established. manifestations tNGS for...
High altitude pulmonary oedema (HAPE) severely affects non-acclimatized individuals and is characterized by alveolar flooding with protein-rich as a consequence of blood-gas barrier disruption. Limited choice for prophylactic treatment warrants effective therapy against HAPE. Keratinocyte growth factor-2 (KGF-2) has shown efficiency in preventing epithelial cell DNA damages vitro. In the current study, effects KGF-2 intratracheal instillation on mortality, lung liquid balance histology were...
Hypoxia and exertion are considered as the two main factors in development of high-altitude pulmonary oedema (HAPE), however its pathophysiology remains unclear. Therefore, we established a model which 32 Sprague–Dawley rats were randomly assigned to normoxic rest, hypoxic exercise exercise. An altitude 4,700 m was simulated using hypobaric hypoxia, while consisted 48 h walk with 15–20 min breaks every 4 h. Arterial blood gas, bronchoalveolar lavage (BAL), lung wet-to-dry weight (W/D) ratio...
Abstract Preservation or restoration of normal alveolar epithelial barrier function is crucial for pulmonary oedema resolution. Keratinocyte growth factor‐2 ( KGF ‐2), a potent cell mitogen, may have role in preventing ventilator‐induced lung injury VILI ), which occurs frequently mechanically ventilated patients. The aim the study was to test ‐2 rats. Forty healthy adult male S prague‐ D awley rats were randomly allocated into four groups, where Groups HVZP (high‐volume zero positive...
Abstract Background Little attention has been paid to the pathophysiological changes in natural history of chronic obstructive pulmonary disease (COPD). The destructions small airways were visualized on thoracic micro-computed tomography scan. We investigated whether airway inflammation (SAI) was risk for development COPD. Methods A total 1062 patients enrolled and analyzed study. partitioned determined by exhaled nitric oxide (NO) FnNO, FeNO 50 , 200 calculated CaNO dual . Both compared...
Abstract Background High altitude pulmonary edema (HAPE) affects individuals and is characterized by alveolar flooding with protein-rich as a consequence of blood-gas barrier disruption. In this study, we hypothesized that aquaporin 5 (AQP5) which one kind water channels may play role in preservation epithelial integrity high (HAPE). Methods Therefore, established model Wildtype mice AQP5 −/− were assingned to normoxic rest (NR), hypoxic (HR) exercise (HE) group. Mice produced training walk...
Less attention has been paid to the pathophysiological changes in atypical asthma such as cough variant (CVA) and chest tightness (CTVA). The obstruction of large small airways is important component development asthma. We investigated whether airway inflammation (SAI) induced dysfunction (SAD) these asthmatics.
Limited information exists about the nature of late-onset asthma (LOA) without medication intervention when compared to early-onset (EOA). Our goal was understand how EOA and LOA affect clinical pathophysiological features.A population-based cross-sectional study carried out in Zhongshan Hospital (Shanghai, China). were based on age diagnosis (before after 40 years, respectively). Clinical variables collected with an emphasis allergic features, analyzed, related, using one-way ANOVA or...
Abstract Background Acute respiratory distress syndrome (ARDS) is a disease with high mortality and morbidity. Regulator of G protein signaling 6 (RGS6), identified as tumor suppressor gene, has received increasing attention owing to its close relationship oxidative stress inflammation. However, the association between ARDS RGS6 not been reported. Methods Congruously regulated protein-coupled receptor (GPCR)-related genes differentially expressed (DEGs) in an acute lung injury (ALI) model...
Chronic obstructive pulmonary disease (COPD) and lung cancer (LC) are two serious diseases that present a major health problem worldwide. However, genetic contribution to both remains unclear, including various regulation mechanisms at level resulting in the progression from COPD LC. In this paper, we describe our comprehensive methodologies, which seamlessly integrate biological (conducted "wet labs") computational (based on domain ontologies semantic technologies) approaches, investigate...
Data that guide selection of differing anticoagulant regimens for specific cancer-associated venous thromboembolism (VTE) are lacking. We aimed to compare the efficacy and safety rivaroxaban low-molecular-weight heparin (LMWH) against nonhigh-risk pulmonary embolism (PE) in Chinese lung cancer patients.Four hundred forty-six patients with PE who initiated treatment or LMWH were identified from Zhongshan Hospital database 2016 2020. The primary outcomes composite event VTE recurrence major...