A5037649561- MRI in cancer diagnosis
- Advanced Neuroimaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Genomic variations and chromosomal abnormalities
- Advanced MRI Techniques and Applications
- Prenatal Screening and Diagnostics
- Functional Brain Connectivity Studies
- Fetal and Pediatric Neurological Disorders
- Parvovirus B19 Infection Studies
- Renal cell carcinoma treatment
- Renal and related cancers
- Liver Disease Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Congenital heart defects research
- Diet and metabolism studies
- Biopolymer Synthesis and Applications
- Congenital Anomalies and Fetal Surgery
- Neural dynamics and brain function
- Coronary Artery Anomalies
- Advanced NMR Techniques and Applications
- Plant biochemistry and biosynthesis
- Ubiquitin and proteasome pathways
- Hepatocellular Carcinoma Treatment and Prognosis
- Maternal Mental Health During Pregnancy and Postpartum
- Breast Cancer Treatment Studies
Panzhihua University
2025
Lianyungang Maternal and Children’s Hospital
2015-2024
Siemens (China)
2022-2024
Zhejiang University
2024
Chongqing University
2024
Siemens Healthcare (Germany)
2024
École Polytechnique Fédérale de Lausanne
2020-2023
Centre d'Imagerie BioMedicale
2020-2023
Yangzhou University
2019
Zhejiang Environmental Monitoring Center
2016
Time-dependent diffusion MRI–based microstructural mapping was shown to be an effective method in helping identify molecular subtypes and predict pathologic complete response neoadjuvant chemotherapy participants with breast cancer.
To explore the relationship between Normalized Wall Index (NWI) and Magnetic Resonance Perfusion Imaging Parameters in Patients with Mild Carotid Artery Stenosis. Initially, an analysis was conducted on 40 patients from our institution, we identified through ultrasonographic examinations July 2021 August 2022. These exhibited carotid artery plaques mild luminal narrowing (with stenosis rates ranging 20 to 50%, following criteria of North American Symptomatic Endarterectomy Trial, NASCET)....
To investigate the clinical efficiency of noninvasive prenatal test (NIPT) identifying fetal chromosomal aneuploidies.In present study, 917 women with high-risk pregnancies were invited to participate in an NIPT trial based on Illumina HiSeq massively parallel sequencing platform. Abnormal cases validated by karyotyping and fluorescence situ hybridization (FISH) analysis. All participants' infants examined clinically followed up for at least 6 months.A total 35 (3.82%) detected abnormal...
Resting state functional MRI (rs-fMRI) is a widespread and powerful tool for investigating connectivity (FC) brain disorders. However, FC analysis can be seriously affected by random structured noise from non-neural sources, such as physiology. Thus, it essential to first reduce thermal then correctly identify remove artifacts rs-fMRI signals through optimized data processing methods. existing tools that correct these effects have been developed human are not readily transposable rat data....
The continuous-time random-walk (CTRW) diffusion model to evaluate breast cancer prognosis is rarely reported.To investigate the correlations between apparent coefficient (ADC) and CTRW-specific parameters with prognostic factors molecular subtypes of cancer.Retrospective.One hundred fifty-seven women (median age, 50 years; range, 26-81 years) histopathology-confirmed cancer.Simultaneous multi-slice readout-segmented echo-planar imaging at 3.0T.The histogram metrics ADC, anomalous (D),...
Type C hepatic encephalopathy (HE) is a complex neuropsychiatric disorder occurring as consequence of chronic liver disease. Alterations in energy metabolism have been suggested type HE, but $\textit{in vivo}$ studies on this matter remain sparse and reported conflicting results. Here, we propose novel preclinical $^{18}$F-FDG PET methodology to compute quantitative 3D maps the regional cerebral metabolic rate glucose (CMR$_{glc}$) from labelling steady-state image brain an image-derived...
Objective To investigate the correlations between quantitative diffusion parameters and prognostic factors molecular subtypes of breast cancer, based on a single fast high-resolution diffusion-weighted imaging (DWI) sequence with mono-exponential (Mono), intravoxel incoherent motion (IVIM), kurtosis (DKI) models. Materials Methods A total 143 patients histopathologically verified cancer were included in this retrospective study. The multi-model DWI-derived quantitatively measured, including...
To determine the optimal scan duration for ultrafast DCE-MRI in effectively differentiating benign from malignant breast lesions.
Brain glucose hypometabolism has been singled out as an important contributor and possibly main trigger to Alzheimer's disease (AD). Intracerebroventricular injections of streptozotocin (icv-STZ) cause brain without systemic diabetes. Here, a first-time longitudinal study metabolism, functional connectivity white matter microstructure was performed in icv-STZ rats using PET MRI. Histological markers pathology were tested at advanced stage disease. STZ exhibited altered intra-axonal damage...
Histogram analysis of the diffusion-weighted imaging (DWI) parameters is widely used to differentiate breast lesions. However, histogram diffusion-kurtosis (DKI) for single-shot echo-planar (ss-EPI) and readout-segmented echo planar (rs-EPI) sequences has not been compared in cancer. Thus, this study investigate diagnostic accuracy reliability derived from rs-EPI ss-EPI DKI distinguishing between benign malignant lesions.This single-center, retrospective cohort enrolled 205 consecutive...
Background Nonmass enhancement (NME) breast lesions are considered to be the leading cause of unnecessary biopsies. Diffusion‐weighted imaging (DWI) or dynamic contrast‐enhanced (DCE) sequences typically used differentiate between benign and malignant NMEs. It is important know which one more effective reliable. Purpose To compare diagnostic performance DCE curves DWI in discriminating NME on basis morphologic characteristics assessment (CE)‐MRI images. Study Type Retrospective. Subjects A...
The recommended technique for breast diffusion-weighted imaging (DWI) acquisitions is not sufficiently standardized in clinical practice.To investigate the intraobserver and interobserver reproducibility of DWI measurements, diffusion-kurtosis (DKI) parameters, image quality evaluation lesions between single-shot echo-planar (ss-EPI) readout-segmented (rs-EPI).Prospective.A total 295 women with 209 malignant 86 benign lesions.A 3-T; fat-saturated T2-weighted MR (T2WI); multi-b-value both...
To investigate the detectability of non-invasive prenatal testing (NIPT) after screening to detect foetal chromosomal abnormalities in pregnant women at high risk, and number could be missed by NIPT.From January 2009 March 2018, 3,099 risk for trisomy 21 18 according results serological were enrolled this study. The underwent amniocentesis 18-23 weeks, as well karyotype and/or microarray analyses (CMA). We assessed ability NIPT abnormalities.In all, 177 (5.7%, 177/3,099) identified. These...
Background Siamese network (SN) using longitudinal DCE‐MRI for pathologic complete response (pCR) identification lack a unified approach to phases selection. Purpose To identify pCR in early‐stage NAC, SN with and introducing IPS Study Type Multicenter, longitudinal. Population Center A: 162 female patients (50.63 ± 8.41 years) divided 7:3 into training internal validation cohorts. B: 61 (50.08 7.82 were used as an external cohort. Field Strength/Sequence single vendor 3.0 T...
Background and aims: X-linked ichthyosis (XLI) is a common recessive genetic disease caused by the deletion of steroid sulfatase (STS) in Xp22.31. Maternal copy-number deletions Xp22.31 (covering STS) can be considered an incidental benefit genome-wide cell-free DNA profiling. Here, we explored accuracy clinical value maternal during non-invasive prenatal screening (NIPS). Materials methods: We evaluated 13,156 pregnant women who completed NIPS. The revealed NIPS were confirmed with white...
To investigate the detectability of noninvasive prenatal screening (NIPS) with conventional sequencing depth to detect fetal copy number variants.We performed a retrospective study in total 19 144 pregnant women. Their cell-free plasma DNA were assessed for trisomy 21, 18, 13, sex chromosome aneuploidies, and genome-wide variants by NIPS at depth.Three hundred seventy-four cases (2.0%, 374/19 144) abnormal results detected, which including 84 (0.4%, 84/19 high risk 90 (0.5%, 90/19...
Objective To explore the genetic basis for a child featuring short stature, saddle nose, cryptorchidism and mental retardation. Methods The his parents were subjected to G-banded karyotyping chromosomal microarray analysis (CMA). Results was found have 46,Y,der(X)t(X;Y)(p22;q11)mat karyotype. CMA has revealed 8.3 Mb deletion at Xp22.33p22.31 43.3 duplication Yq11.221qter. His mother had karyotype of 46,X,der(X)t(X;Y)(p22;q11). father normal Conclusion carried an unbalanced translocation...