A5041687642- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genetic factors in colorectal cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Hepatitis C virus research
- Cancer, Lipids, and Metabolism
- Parasite Biology and Host Interactions
- Cancer, Hypoxia, and Metabolism
- Parasites and Host Interactions
- Ferroptosis and cancer prognosis
- Ubiquitin and proteasome pathways
- RNA Research and Splicing
- Parasitic infections in humans and animals
- Cancer Genomics and Diagnostics
- Protein Kinase Regulation and GTPase Signaling
- Mitochondrial Function and Pathology
- Porphyrin Metabolism and Disorders
- Microbial metabolism and enzyme function
- PI3K/AKT/mTOR signaling in cancer
- Whipple's Disease and Interleukins
- Peptidase Inhibition and Analysis
- Cholesterol and Lipid Metabolism
- Thyroid and Parathyroid Surgery
Xuzhou Medical College
2013-2024
Wuhan University
2024
Renmin Hospital of Wuhan University
2024
Jinzhou Medical University
2020
Soochow University
2011-2013
Suzhou Municipal Hospital
2012
First Affiliated Hospital of Soochow University
2012
Nanjing Medical University
2012
Fudan University
2012
Shanghai Veterinary Research Institute
2012
The Prolyl hydroxylase 1 (EGLN2) is known to affect tumorigenesis by regulating the degradation of hypoxia-inducible factor. Polymorphisms in EGLN2 may facilitate cancer cell survival under hypoxic conditions and directly associate with susceptibility. Here, we examined contribution a 4-bp insertion/deletion polymorphism (rs10680577) within distal promoter risk hepatocelluar carcinoma (HCC) Chinese populations. rs10680577 HCC was investigated 623 cases 1,242 controls replicated an...
Glioblastoma multiforme (GBM) is the most prevalent and lethal primary intracranial neoplasm in adult population, with treatments of limited efficacy. Recently, bufotalin has been shown to have anti-cancer activity a variety cancers. This investigation aims investigate effect on GBM elucidate its potential underlying mechanism. Our results show that not only inhibits proliferation epithelial-mesenchymal transition (EMT) but also triggers apoptosis cells. The result RNA-seq indicated could...
The 14-bp insertion/deletion (indel) polymorphism located in the 3' UTR of human leukocyte antigen-G (HLA-G) gene plays a role several autoimmune and chronic inflammatory diseases. HLA-G expression is associated with hepatocellular carcinoma (HCC) prognosis, especially early stage, high independently shortened overall survival increased tumor recurrence. In present study, we carried out case-control study Chinese population (318 cases 599 controls) to estimate susceptibility HCC indel...
Abstract MiR-124 functions as a tumor suppressor and plays an important role in tumorigenesis. A common polymorphism (rs531564, C>G) the pri-miR-124 has been recently studied connection with cancer risk. The aim of present study was to investigate association between rs531564 risk clinicopathological characteristics colorectal (CRC). Two case-control studies involving 900 CRC patients 1110 cancer-free controls showed that significantly associated decreased Xuzhou population [GG vs. CC: OR...
Background BRM (Brahma homologue) is well known for its critical role in tumor suppression and cancer development. Genetic variations the promoter region of have been suggested to be associated with loss expression lung risk. To authors’ knowledge, no study on genetic polymorphisms hepatocellular carcinoma (HCC) risk has performed. Methodology/Principal Findings In two independent case-control studies containing 796 HCC cases 806 cancer-free individuals, we genotyped putative functional...
MicroRNAs-associated single nucleotide polymorphisms are thought to play an important role in cancer development. We investigated the association of miR-146a rs2910164 polymorphism with risk colorectal (CRC) Chinese population.In this hospital-based case-control study 560 cases and 780 age- gender-matched healthy controls, was genotyped by polymerase chain reaction-restriction fragment length polymorphism.We found that not associated CRC risk. However, subgroup analysis gender showed...
Up to now, the ‘hardwired’ neural pathway of neuro-immune regulation is not fully understood. Here we reported a new which links sympathetic nerves with immune cells lymphoid tissues. Our results demonstrated that nerve fibers derived from superior cervical ganglion directly targeted only S100+ in lymph nodes. Moreover, found co-expression neurotransmitters such as norepinephrine, vasoactive intestinal polypeptide and neuropeptide Y postganglionic endings innervate cells. findings suggested...
Objective To investigate the association between susceptibility to colorectal cancer (CRC) and a 4-bp insertion/deletion polymorphism (rs10680577) in proximal promoter of EGLN2 gene. Method The first step genotyping was PCR, then PCR products were separated using 7% nondenaturing polyacrylamide gel electrophoresis visualized by silver staining according final product band location quantity determine genotype sample. count done two different pathologists. Result In codominant model, compared...
As a complement to chemotherapy and other control approaches, the development of an effective vaccine is necessary combat Schistosomiasis japonica that remains serious public health problem in China. In present study, mice were vaccinated with purified recombinant protein LHD-Sj23-GST (large hydrophilic domain 23 kDa antigen S. japonicum fused Sj26GST) emulsified Freund's adjuvant (FA), Montanide ISA 206 70 M challenged cercariae, protective efficacy induced by was evaluated,...
Background: Growth arrest specific 5 (GAS5) has been reported as a tumor repressor in multiple cancers, but the role of indel polymorphism rs145204276 within GAS5 cervical squamous cell carcinoma (CSCC) susceptibility not well established yet.Methods: A hospital based case-control study Shehong and Xuzhou centers was performed to evaluate potential association with CSCC risk, further vivo vitro assays were applied confirm plausible association.Results: When taking ins/ins genotype reference...
Colorectal cancer (CRC) is the most common worldwide. Both genetic and environmental factors play an important role in pathogenesis of CRC, susceptibility may be modified by functional polymorphisms receptor tyrosine kinase genes, such as ErbB4. We here evaluated whether a 12-bp insertion/deletion (indel) polymorphism (rs6147150) 3'UTR ErbB4 could potentially affect occurrence CRC Chinese population.We studied genotypic allelic frequencies 399 patients with 419 control participants using...
Hepatocellular carcinoma (HCC) represents the most common primary malignancy of liver with a worldwide increasing incidence. Although risk factors for HCC are well characterized, molecular mechanisms responsible malignant transformation hepatocytes not understood. In this study, case–control study including 291 patients and 294 healthy controls was conducted to investigate association between susceptibility 4-bp insertion/deletion polymorphism (rs66465034) in proximal promoter CD3G. Logistic...
This study's aim consists of evaluating the adhesion and proliferation mesenchymal stem cells (MSCs) derived from rat bone marrow on nanoparticle Titanium (Ti) surface. Hence, passage 3 MSCs were, respectively, seeded Ti pure surfaces then cultured for 32 h. Cell morphology viability were separately examined by scanning electron microscopy 3-(4,5-dimethylthiazsol-2-yl)-2,5-diphenyltetrazolium bromide assay. Moreover, mitotic rate attached was observed through immunocytochemistry. The...
Accumulating evidence has indicated that runt-related transcription factor 3 (RUNX3) gene polymorphism (rs7528484) is associated with an alimentary system cancer risk. However, the role of rs7528484 in colorectal still unclear. The present study aimed to explore association between and susceptibility a Chinese Han population.We firstly investigated effect distal promoter RUNX3 on risk population comprising 427 patients 503 controls. We then carried out phenotype-genotype analysis validate...