A5101796132- Histone Deacetylase Inhibitors Research
- T-cell and Retrovirus Studies
- Acute Myeloid Leukemia Research
- Natural product bioactivities and synthesis
- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Chronic Myeloid Leukemia Treatments
- Protein Degradation and Inhibitors
- Traditional Chinese Medicine Analysis
- Hematopoietic Stem Cell Transplantation
- SARS-CoV-2 and COVID-19 Research
- Pharmacological Effects of Natural Compounds
- Circadian rhythm and melatonin
- SARS-CoV-2 detection and testing
- Plant tissue culture and regeneration
- Ubiquitin and proteasome pathways
- Healthcare and Venom Research
- Peptidase Inhibition and Analysis
- Immune Cell Function and Interaction
- COVID-19 epidemiological studies
- Aquatic life and conservation
- Ginseng Biological Effects and Applications
- Aquaculture Nutrition and Growth
- Plant Gene Expression Analysis
- Seed Germination and Physiology
Beijing Center for Disease Prevention and Control
2023-2025
Ruijin Hospital
2023-2024
Hunan University of Traditional Chinese Medicine
2021-2024
Inner Mongolia Medical University
2024
Shanghai Institute of Hematology
2020-2023
Shanghai University of Traditional Chinese Medicine
2022-2023
Shanghai Jiao Tong University
2020-2023
Guangzhou Medical University
2023
Huazhong Agricultural University
2013-2016
Institute of Hematology & Blood Diseases Hospital
2016
Long noncoding RNAs (lncRNAs) are transcripts of at least 200 bp in length, possess no apparent coding capacity and involved various biological regulatory processes. Until now, systematic identification lncRNAs has been reported cotton (Gossypium spp.). Here, we describe the 30 550 long intergenic RNA (lincRNA) loci (50 566 transcripts) 4718 natural antisense transcript (lncNAT) (5826 transcripts). LncRNAs rich repetitive sequences preferentially expressed a tissue-specific manner. The...
Summary As a product of asexual reproduction in plants, the somatic embryo ( SE ) differentiates into new plantlet via zygotic embryogenesis‐like process. Here, we present phenotypic and cellular differences between s embryos ZE s) revealed by histological section scanning using three parallel development stages two types cotton G ossypium hirsutum cv. YZ 1), including globular, torpedo cotyledonary‐stages. To identify molecular characteristics cotton, digital gene expression system was used...
Somatic embryogenesis (S.E.) is a versatile model for understanding the mechanisms of plant and useful tool propagation. To decipher intricate molecular program potentially to control parameters affecting frequency S.E., proteomics approach based on two-dimensional gel electrophoresis (2-DE) combined with MALDI-TOF/TOF was used. A total 149 unique differentially expressed proteins (DEPs) were identified at different stages cotton S.E. compared initial (0 h explants). The expression profile...
Peripheral T-cell lymphoma (PTCL) is a heterogeneous and aggressive disease with poor prognosis. Histone deacetylase (HDAC) inhibitors have shown inhibitory effects on PTCL. A better understanding of the therapeutic mechanism underlying HDAC could help improve treatment strategies. Herein, we found that high expression HDAC3 associated prognosis in inhibition suppressed growth immunocompetent mice but not immunodeficient mice. deletion delayed progression lymphoma, reduced burden thymus,...
Investigating immune memory to vaccinia virus and pre-existing immunity mpox (MPXV) among the population is crucial for global response this ongoing epidemic. Blood was sampled from vaccinees inoculated with Tiantan (VTT) strain born before 1981 unvaccinated control subjects since 1982. After at least 40 years of inoculation, 60% or 5% VTT possess neutralizing antibodies (NAbs) MPXV, 50% having T cell protein antigens. Notably, 46.7% show responses MPXV. Broad CD8+ reactivities MPXV are...
Colon cancer is a highly malignant with poor prognosis. Astragalus membranaceus (Fisch.) Bunge (Huang Qi in Chinese, HQ), well-known Chinese herbal medicine and popular food additive, possesses various biological functions has been frequently used for clinical treatment of colon cancer. However, the underlying mechanism not fully understood. Isoflavonoids, including formononetin (FMNT) calycosin (CS), are main bioactive ingredients isolated from HQ. Thus, this study aimed to explore...
To study the effect of Gupi Xiaoji Prescription (GXP) on hepatitis B virus(HBV)-related liver cancer through network pharmacology coupled with in vitro experiments and explore their related mechanisms. Prescription's chemical constituents action targets its six medicinal components were identified using several databases. These included Traditional Chinese Medicine Systems Pharmacology Database (TCMSP), Bioinformatics Analysis Tool for Molecular mechANism TCM (BATMAN-TCM), Integrated...
Background: Serum pro-gastrin releasing peptide (proGRP) is a well-recognized diagnostic marker for small cell lung cancer (SCLC). Pleural effusion common in patients with advanced SCLC. The accuracy of pleural proGRP malignant (MPE) has not yet been established. This study aimed to evaluate the MPE. Methods: We prospectively recruited undiagnosed effusions from two centers (Hohhot and Changshu). An electrochemiluminescence immunoassay was used detect fluid proGRP. MPE evaluated using...
Abstract Background N6A methylation (m6A) is a significant epigenetic modification that critically impacts post-transcriptional regulation and tumor occurrence development. While previous studies have identified role for in hepatocellular carcinoma (HCC), the potential function of m6A cluster Hepatitis B virus (HBV)-related HCC remains unclear. Methods The related information was downloaded from Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO). Based on expression 20 regulators, we...
Relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) with standard myeloablative conditioning regimens such as fludarabine (Flu) and busulfan (Bu) remains a major concern in patients myeloid malignancies. A low relapse rate has been reported when thiotepa or melphalan (Mel) is added to Flu-Bu, but at possible increased risk of nonrelapse mortality (NRM). Here we evaluated the outcomes 100 (70 acute leukemia, 23 myelodysplastic syndrome, 4 chronic myelomonocytic 3...
The PT-Cy was considered as one of the mainstay protocol for graft verus host disease (GVHD) prophylaxis. Recent study demonstrated that combined with other immunosuppressants could further reduce incidence GVHD and improve relapse free survival (GRFS). In this prospective phase II study, we evaluated effect a new prophylaxis consist tacrolimus low dose anti-thymoglobulin (ATG). A total 23 patients were enrolled including 20 acute lymphoblastic leukemia (ALL) three T cell lymphoma. median...
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This study tried to reveal how the implementation and cancellation of dynamic zero-COVID policy could affect development epidemic through wastewater surveillance SARS-CoV-2 in Beijing during its first COVID-19 surge. A total 443 24 h composite samples were taken from seven manholes 10 treatment plants immediately on December 7, 2022, when new was implemented, for detection SARS-CoV-2. The results showed that surge characterized by a rapid outbreak, short duration (one month), extremely high...
During the COVID-19 pandemic, healthcare systems worldwide faced severe strain. This study, utilizing wastewater virus surveillance, identified that periodic spontaneous avoidance behaviors significantly impacted infectious disease transmission during rapid and intense outbreaks. To incorporate these into analysis, we introduced Su-SEIQR model validated it using data from Beijing Hong Kong. The results demonstrated accurately reflected trends in susceptible populations confirmed cases...
Abstract Background Corosolic acid is a pentacyclic triterpene with hypoglycemic, anti-inflammatory, and anti-cancer effects. However, its potential targets in hepatocellular carcinoma (HCC) are unknown, hindering clinical utilization. Methods Differentially expressed proteins of the Bel-7404 cell line were identified tandem mass tag analysis differentially genes (DEGs) an HCC TCGA dataset using bioinformatics. Gene functions pathways inferred DAVID database. Online databases used to...
<h2>Summary</h2> Internal tandem duplication mutations of the FMS-like tyrosine kinase-3 (FLT3-ITDs) occur in 25%–30% patients with acute myeloid leukemia (AML) and are associated dismal prognosis. Although FLT3 inhibitors have demonstrated initial clinical efficacy, overall outcome FLT3-ITD AML remains poor, highlighting urgency to develop more effective treatment strategies. In this study, we reveal that reduced protein stability anti-cancer p53, resulting drug resistance. Blocking p53...