A5100337081- Vasculitis and related conditions
- Monoclonal and Polyclonal Antibodies Research
- Systemic Lupus Erythematosus Research
- Pain Mechanisms and Treatments
- Renal Diseases and Glomerulopathies
- Atherosclerosis and Cardiovascular Diseases
- Tracheal and airway disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Obstructive Sleep Apnea Research
- Liver Disease Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Salivary Gland Disorders and Functions
- Spine and Intervertebral Disc Pathology
- HER2/EGFR in Cancer Research
- Management of metastatic bone disease
- Congenital Diaphragmatic Hernia Studies
- Neuroscience and Neuropharmacology Research
- Gut microbiota and health
- Vascular Malformations and Hemangiomas
- Renal and Vascular Pathologies
- Lysosomal Storage Disorders Research
- Pharmacological Effects of Natural Compounds
- Systemic Sclerosis and Related Diseases
- Neuropeptides and Animal Physiology
- Respiratory Support and Mechanisms
Air Force Medical University
2015-2025
Peking Union Medical College Hospital
2016-2025
General Hospital of Shenyang Military Region
2015-2025
Wangjing Hospital of China Academy of Chinese Medical Sciences
2025
Henan Cancer Hospital
2025
Zhengzhou University
2020-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Ministry of Education of the People's Republic of China
2014-2025
National Clinical Research Center for Digestive Diseases
2020-2025
The University of Texas MD Anderson Cancer Center
2017-2025
Aim . Based on the previously established method, we developed a better and stable animal model of type 2 diabetes mellitus by high‐fat diet combined with multiple low‐dose STZ injections. Meanwhile, this new was used to evaluate antidiabetic effect berberine. Method Wistar male rats fed regular chow for 4 weeks received vehicle (control groups), different amounts once or twice intraperitoneal injection (diabetic diabetic were treated berberine (100 mg/kg, treatment group). Intraperitoneal...
The human salivary microbiome may play a role in diseases of the oral cavity and interact with microbiomes from other parts body (in particular, intestinal tract), but little is known about normal variation microbiome. We analyzed 14,115 partial (∼500 bp) 16S ribosomal RNA (rRNA) sequences saliva samples 120 healthy individuals (10 each 12 worldwide locations). These could be assigned to 101 bacterial genera, which 39 were not previously reported cavity; phylogenetic analysis suggests that...
To characterize the clinical features of IgG4-related disease (IgG4-RD) in China.A prospective cohort study IgG4-RD was carried out Peking Union Medical College Hospital between 2011 and 2013. Patients with newly diagnosed were enrolled.A total 118 patients enrolled, including 82 males 36 females, aged 53.1 (s.d. 13.6) years. The most common symptom at onset lacrimal gland swelling (38/32.2%). A range organs involved: 77 (65.3%) had lymphadenopathy, 76 (64.4%) sialadenitis, 60 (50.8%)...
To compare the efficacy and safety of Tripterygium wilfordii Hook F (TwHF) with methotrexate (MTX) in treatment active rheumatoid arthritis (RA).Design: a multicentre, open-label, randomised controlled trial. All patients were assessed by trained investigators who unaware therapeutic regimen.207 RA randomly allocated (1:1:1) to MTX 12.5 mg once week, or TwHF 20 three times day, two combination. At week 12, if reduction 28-joint count Disease Activity Score (DAS28) was <30% monotherapy...
To investigate the clinical features of adult patients with hemophagocytic lymphohistiocytosis (HLH) and to explore possible risk factors for death, we retrospectively reviewed medical records 103 HLH hospitalized from 1997 2012. We analyzed underlying diseases, characteristics, 1aboratory findings, outcomes, prognostic factors. The most common cause was hematologic malignancies (n = 49), followed by infectious diseases 24) autoimmune disorders 14); 24 cases were unknown etiology. Eight had...
Abstract First-line systemic therapeutic options for advanced esophageal squamous cell carcinoma (ESCC) are limited. In this multicenter, double-blind phase 3 trial, a total of 551 patients with previously untreated, locally or metastatic ESCC and PD-L1 combined positive score ≥1 were randomized (2:1) to receive serplulimab (an anti-PD-1 antibody; mg/kg) placebo (on day 1), plus cisplatin (50 mg/m 2 ) 1) continuous infusion 5-fluorouracil (1,200 days 1 2), once every weeks. The study met the...
The ERK-MAPK signaling pathway plays a pivotal role during mesenchymal stem cell (MSC) differentiation. Studies have demonstrated that promotes adipogenesis and osteogenesis through the phosphorylation of differentiation-associated transcription factors it is only active in all three lineages (adipogenic, chondrogenic, osteogenic) MSC Recent studies pointed to significant roles microRNA-21 (miR-21) several physiological pathological processes, especially fate determination. miR-21 expression...
Subcutaneous (SC) delivery is a common route of administration for therapeutic monoclonal antibodies (mAbs) with pharmacokinetic (PK)/pharmacodynamic (PD) properties requiring long-term or frequent drug administration. An ideal in vivo preclinical model predicting human PK following SC may be one which the skin and overall physiological characteristics are similar to that humans. In this study, series mAbs intravenous (IV) Göttingen minipigs were compared data obtained previously from The...
Primary Sjögren syndrome (pSS) is a systemic autoimmune disease associated with dysregulated immune cells, no efficient therapy. There need to study potential therapeutic approaches.To investigate the efficacy, safety, and response of low-dose interleukin 2 (LD-IL-2) in treatment pSS.A double-blind, placebo-controlled randomized clinical trial was conducted 2-group superiority design from June 2015 August 2017. Sixty patients, aged 18 70 years, were recruited Peking University People's...
This phase 2b, randomised, double-blind, placebo-controlled trial evaluated the efficacy and safety of telitacicept, a novel fusion protein that neutralises signals B lymphocyte stimulator proliferation-inducing ligand, in active systemic lupus erythematosus (SLE).
Abstract Background Nurses play an important role in healthcare development. The increasing demands for nurses mean that nursing schools at the undergraduate level have responsibility to ensure patient safety and quality care through a well-designed curriculum. This research aimed evaluate effect of teaching method combined with situational awareness case-based seminars comprehensive skills practice course on self-directed learning, professional identity, academic self-efficacy, theoretical...
Advances in treatment have swiftly alleviated systemic inflammation of Takayasu's arteritis (TAK), while subclinical vascular and the ensuing arterial remodeling continue to present unresolved challenges TAK. The phenotypic switching smooth muscle cells (VSMC) is regarded as first step pathology contributes remodeling. Exosomes facilitate transfer exchange proteins specific nucleic acids, thereby playing a significant role intercellular communication. Little known about modulatory serum...
We describe the saliva microbiome diversity in Batwa Pygmies, a former hunter-gatherer group from Uganda, using next-generation sequencing of partial 16S rRNA sequences. Microbial community is significantly higher than agricultural groups Sierra Leone and Democratic Republic Congo. found 40 microbial genera Batwa, which have previously not been described human oral cavity. The distinctive composition salvia may influenced by their recent different lifestyle diet.
As the population ages, medical and socioeconomic impact of age-related bone disorders will further increase. An imbalance between osteogenesis adipogenesis mesenchymal stem cells (MSCs) can lead to various metabolic diseases such as osteoporosis. Thus, understanding molecular mechanisms underlying MSC osteogenic adipogenic differentiation is important for discovery novel therapeutic paradigms these diseases. miR-10b has been widely reported in tumorigenesis, cancer invasion metastasis....
Epitope mapping the specific residues of an antibody/antigen interaction can be used to support mechanistic interpretation, antibody optimization, and epitope novelty assessment. Thus, there is a strong need for methods, particularly integrative ones. Here, we report identification energetic by determining interfacial hot-spot that dominates binding affinity anti-interleukin-23 (anti-IL-23) using complementary approaches hydrogen/deuterium exchange mass spectrometry (HDX-MS), fast...
Objective: To determine the prophylactic efficacy of short-term intensive preoperative inspiratory muscle training on incidence postoperative pulmonary complications in patients scheduled for cardiac surgery. Design: Single-blind, randomized controlled pilot study. Setting: TEDA International Cardiovascular Hospital, China. Subjects: In total, 197 subjects aged ⩾50 years surgery were selected. Intervention: The intervention group ( n = 98) received five days top usual care by control 99)....
Bladder cancer (BC) and Renal cell carcinoma(RCC) are the two most frequent genitourinary cancers in China. In this study, a comprehensive liquid chromatography-mass spectrometry (LC-MS) based method, which utilizes both plasma metabolomics lipidomics platform, has been carried out to discriminate global profiles of 64 patients with BC, 74 RCC, 141 healthy controls. Apparent separation was observed between (BC RCC) samples The area under receiving operator characteristic curve (AUC) 0.985...