A5101525190- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Cancer-related molecular mechanisms research
- DNA Repair Mechanisms
- Genetic Associations and Epidemiology
- Hedgehog Signaling Pathway Studies
- MicroRNA in disease regulation
- Congenital limb and hand anomalies
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Metabolism, Diabetes, and Cancer
- Cytokine Signaling Pathways and Interactions
- Circular RNAs in diseases
- Microbial Natural Products and Biosynthesis
- Evolution and Genetic Dynamics
- Genetic factors in colorectal cancer
- Genetic and Kidney Cyst Diseases
- HIV-related health complications and treatments
- Renal and related cancers
- interferon and immune responses
- Fungal Biology and Applications
- Nuclear Structure and Function
- Inflammasome and immune disorders
- Pancreatic function and diabetes
- Marine Sponges and Natural Products
Ministry of Education of the People's Republic of China
2019-2025
Harbin Medical University
2016-2025
Jinan University
2024
Hainan Normal University
2022-2024
Wuhan City Chinese Medicine Hospital
2023-2024
Hainan University
2022-2023
Second Affiliated Hospital of Harbin Medical University
2018
Zero to Three
2012
Harbin University
2012
Wellcome Sanger Institute
2009
Virus infection is one of the greatest threats to human life and health. In response viral infection, host’s innate immune system triggers an antiviral mostly mediated by inflammatory processes. Among many pathways involved, nucleotide-binding oligomerization domain (NOD)-like receptor protein 3 (NLRP3) inflammasome has received wide attention in context infection. The NLRP3 intracellular sensor composed three components, including NLRP3, adaptor apoptosis-associated speck-like containing...
The NOD-like receptor (NLR) signaling pathway may influence human immunodeficiency virus (HIV) clearance and CD4+ T cell recovery through inflammatory responses, but its specific mechanism requires further investigation. A deeper understanding of genetic variations can provide new insights into the biological mechanisms underlying occurrence development syndrome (AIDS). By utilizing multiple bioinformatic analyses functional annotations, we identified single-nucleotide polymorphisms (SNPs)...
We have evaluated the extent to which SNPs identified by genomewide surveys as showing unusually high levels of population differentiation in humans experienced recent positive selection, starting from a set 32 nonsynonymous 27 genes highlighted HapMap1 project. These were genotyped again HapMap samples and Human Genome Diversity Project-Centre d'Etude du Polymorphisme Humain (HGDP-CEPH) panel 52 populations representing worldwide diversity; extended haplotype homozygosity was investigated...
Six new polyketides, which includes three lactones (talarotones A–C) (1–3) , one polyketide (talarotide A) (4) two polyenes (talaroyenes A, B) (5, 6) together with meroterpenoid (talaropenoid (7) and 13 known compounds (8–20) were isolated from the mangrove-derived fungus Talaromyces flavus TGGP35. The structure configuration of 1 – 7 elucidated data obtained HR-ESI-MS, IR, 1D/2D NMR spectroscopy, Mo 2 (OAc) 4 -induced electronic circular dichroism (ECD), CD modified Mosher's method....
Infections of hepatotropic viruses cause a wide array liver diseases including acute hepatitis, chronic hepatitis and the consequently developed cirrhosis hepatocellular carcinoma (HCC). Among five classical viruses, B virus (HBV) C (HCV) usually infect human persistently leading to major troubles humanity. Previous studies have revealed that several types inflammasomes are involved in infections HBV HCV. Here, we summarize current knowledge about their roles C. NLRP3 inflammasome can be...
// Haiming Sun 1, 2 , Xuelong Zhang 1 Donglin Xueyuan Jia Lidan Xu Yuandong Qiao and Yan Jin Laboratory of Medical Genetics, Harbin University, 150081, China National Human Genome Research Institute, Institutes Health, Baltimore, MD 21224, USA Correspondence to: Jin, email: jinyan@ems.hrbmu.edu.cn . Keywords: COX-2, ovarian cancer, meta-analysis, prognosis Received: February 24, 2017 Accepted: July 12, Published: October 04, ABSTRACT The prognostic role COX-2 expression in cancer patients...
Objective. It has been reported that some single-nucleotide polymorphisms (-13910C/T, -22018G/A, -13907C/G, -13915T/G, and -14010G/C) within the lactase gene are associated with persistence. In our previous study, we found -13910C/T is not a good predictor of persistence in Chinese populations. To obtain better understanding mechanism persistence, examined frequencies Northern China four other alleles Material methods. We evaluated allele -14010G/C six northern populations (Manchu, Mongol,...
The murine double minute 2 (MDM2) gene encodes a negative regulator of the tumour protein p53. A single nucleotide polymorphism (SNP) in MDM2 promoter, SNP309 T > G, has been showed to influence expression and accelerate formation. To investigate further role this locus, we examined association SNP with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) northeast Han Chinese population.MDM2 was genotyped 310 HBV-related HCC patients, 314 non-HCC subjects HBV infection 480 healthy...
Previous studies have identified three loci (rs4737009, rs515071 and rs516946) in ankyrin 1 (ANK1) that are associated with type 2 diabetes mellitus (T2DM) a number of ethnic groups. However, the impact single nucleotide polymorphisms (SNPs) ANK1 on T2DM Han Chinese population from northeast China has not yet been studied. The present study was undertaken to investigate relationship between gene new-onset northeastern China. Three widely studied variants were genotyped analyzed for...
Heilongjiang Province located in northeast China is a multi-ethnic region with people who have lived cold conditions for several generations. Fatty acids are important to resistance. CPT1A encodes protein that imports long-chain fatty into the mitochondria fatty-acid oxidation. FADS an essential enzyme synthesis of polyunsaturated acids. In present study, we investigated distributions three resistance-related SNPs (rs80356779 G > A CPT1A, rs7115739 T FADS3 and rs174570 C FADS2) from six...
Hepatocyte nuclear factor 1β (HNF1β), a transcription encoded by the 2 gene (TCF2), plays critical role in pancreatic cell formation and glucose homeostasis. It has been suggested that single nucleotide polymorphisms (SNPs) of TCF2 are associated with susceptibility to type diabetes (T2D). However, published results inconsistent inclusive. To further investigate these common variants, we examined association risk T2D Han population northeastern China. We genotyped five SNPs 624 patients 630...
Background Lumbar disc herniation (LDH) is a common spinal disease that can cause severe radicular pain. Massage, also known as Tuina in Chinese, has been indicated to exert an analgesic effect patients with LDH. Nonetheless, the mechanism underlying this of massage on LDH remains unclarified. Methods Forty Sprague-Dawley rats were randomly divided into four groups. A rat model was established by autologous nucleus pulpous (NP) implantation, followed treatment or without massage. toll-like...
Abstract Background Congenital cataract is a Mendelian disorder that frequently causes blindness in infants. To date, various cataract-associated loci have been mapped; more than 30 genes identified by linkage analysis. However, the pathogenic some affected families are still unknown, and new research strategies needed. In this study, we used linkage-exome combinational analysis to further investigate pedigree of four-generation Chinese family with autosomal dominant coralliform cataract....
An Indian study recently observed three new loci: rs9552911 in the SGCG, rs1593304 near PLXNA4 and rs4858889 SCAP associated with type 2 diabetes mellitus (T2DM) a south Asian population. The present aimed to validate these findings Chinese We genotyped above single-nucleotide polymorphisms (SNPs), rs9552911, rs1593304, rs4858889, group of 1,972 individuals, comprising 966 diabetic patients 976 controls. Anthropometric variables biochemical traits were measured all participants. association...