A5101973094- Lymphoma Diagnosis and Treatment
- Head and Neck Cancer Studies
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Retinal and Macular Surgery
- CNS Lymphoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Intraocular Surgery and Lenses
- Head and Neck Surgical Oncology
- Sirtuins and Resveratrol in Medicine
- Salivary Gland Tumors Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Autophagy in Disease and Therapy
- Glaucoma and retinal disorders
- Liver Disease Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Alcohol Consumption and Health Effects
- Cancer Immunotherapy and Biomarkers
- Helicobacter pylori-related gastroenterology studies
- Tryptophan and brain disorders
- Adipose Tissue and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Vascular Malformations Diagnosis and Treatment
- Cutaneous lymphoproliferative disorders research
- Lung Cancer Diagnosis and Treatment
University of South China
2025
Taiyuan University of Technology
2024
Tianjin Medical University Cancer Institute and Hospital
2012-2023
Shanxi Eye Hospital
2014-2022
National Clinical Research
2019-2022
Harbin Medical University
2008-2022
Beijing HuiLongGuan Hospital
2011-2022
Peking University
2022
University of Benin
2022
Nanjing Medical University
2011-2021
Lipotoxicity induced by saturated fatty acids (SFAs) plays a central role in the pathogenesis of nonalcoholic liver disease (NAFLD); however, exact mechanisms remain to be fully elucidated. Sirtuin 3 (SIRT3) is nicotinamide adenine dinucleotide–dependent deacetylase located primarily inside mitochondria. In this study, we demonstrated that an SFA‐rich high‐fat diet (HFD) was more detrimental than isocaloric unsaturated HFD rich acids. Unexpectedly, SIRT3 expression and activity were...
Chronic alcohol consumption leads to hypertriglyceridemia, which is positively associated with alcoholic liver disease (ALD). However, whether and how it contributes the development of fatty injury are largely unknown. In this study we demonstrate that chronic exposure differently regulates expression very-low-density lipoprotein receptor (VLDLR) in adipose tissue liver. Whereas VLDLR significantly down-regulated, its hepatic dramatically increased after feeding. While HepG2 cells stably...
PurposeTelomerase is reactivated in non-small cell lung cancer (NSCLC), and it increases resistance to irradiation through protecting damaged telomeres enhancing DNA damage repair. We investigated the radiosensitizing effect of BIBR1532, a highly selective telomerase inhibitor, its corresponding mechanism NSCLC.Methods MaterialsCell proliferation, activity, telomere dysfunction-induced foci were measured with CCK-8 assay, real-time fluorescent quantitative polymerase chain reaction,...
The objective of the study was to describe age distribution and evaluate role prognostic value on survival in patients diagnosed with olfactory neuroblastoma (ONB). A population-based retrospective analysis conducted.The Surveillance, Epidemiology, End Results (SEER) tumor registry, who were ONB from 1973 2014, retrospectively analyzed.The cohort included 876 a median 54 years. There unimodal ONBs most frequently occurred fifth sixth decades life. Kaplan-Meier demonstrated overall (OS)...
Oxidative stress in adipose tissue plays an etiological role a variety of obesity-related metabolic disorders. We previously reported that increased 4-hydroxynonenal (4-HNE) contents contributed to plasma adiponectin decline mice. In the present study, we investigated effects intracellular 4-HNE accumulation on lipolytic response adipocytes/adipose tissues and underlying mechanisms. both fully-differentiated 3T3-L1 primary adipocytes, 5-hour exposure elevated reaction dose-dependent manner...
Overactive lipolysis in adipose tissue contributes to the pathogenesis of alcoholic liver disease (ALD); however, mechanisms involved have not been elucidated. We previously reported that chronic alcohol consumption produces a hypomethylation state tissue. In this study we investigated role alcohol-induced and whether its correction well-established hepatoprotective effect betaine ALD.Male C57BL/6 mice were divided into four groups started on one treatments for 5 weeks: isocaloric pair-fed...
Treatment options for patients with recurrent/metastatic nasopharyngeal carcinoma (RM-NPC) are not clear after progression on previous treatment PD-(L)1 inhibitor; critical gaps in evidence remain such cases. Immunotherapy combined antiangiogenic therapy has been reported to have synergistic antitumor activity. Therefore, we evaluated the efficacy and safety of camrelizumab plus famitinib RM-NPC who failed PD-1 inhibitor-containing regimens. This multicenter, adaptive Simon minimax...
Abstract Background Rhinitis and asthma are very common diseases involving genetic environmental factors. Most patients with also have rhinitis, which suggests the concept of 'one airway, one disease.' A disintegrin metalloproteinase 33 (ADAM33) is first asthma-susceptible gene to be discovered by positional cloning. To evaluate potential influence ADAM33 polymorphisms on allergic rhinitis (AR) (AS), a case-control study was conducted Han population northeast China. Methods Six polymorphic...
Citrus aurantium L. var. amara Engl. (CAVA) was traditionally used as an edible and medicinal material in China. Total flavonoids (CAVAF), alkaloids (CAVAA), polysaccharides (CAVAP), coumarins (CAVAC), neroli (CAVAO) were extracted from CAVA. Hesperidin, naringin, neohesperidin composed 83.94% of CAVAF, synephrine represented 50.56% CAVAA. On the basis 1,1-diphenyl-2-picrylhydrazyl radical (DPPH•), 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt cation (ABTS• +),...
Objectives: Data on breast squamous cell carcinoma (SCC) are rare. The aim of this study was to analyze the clinical characteristics and explore rational treatment patients with SCC. Patients methods: We conducted a retrospective review SCC cases treated at our center from 1966 2014. majority these received primary surgery followed by adjuvant chemoradiotherapy, whilst four elderly had lumpectomy only. Results: were usually women, large masses, proportion early stage disease, low levels...
Oxidative stress and inflammation are regarded as prime reasons for the progression development of diabetic retinopathy. Currently, nuclear factor erythroid-2-related 2 (Nrf2), thioredoxin interacting protein (TXNIP) NLRP3 inflammasome pathways under increasing focus in research on oxidative inflammation-related diseases. On other hand, tilianin (TN) has received much attention because its various pharmacological properties. Based results these studies, this investigation was performed to...
Purpose Retinal vein occlusion (RVO) is the second most common cause of vision loss after diabetic retinopathy due to retinal vascular disease. nonperfusion (RNP), identified on fluorescein angiograms (FA) and appearing as hypofluorescence regions, one significant characteristics RVO. Quantification RNP crucial for assessing severity progression However, in current clinical practice, it mostly conducted manually, which time‐consuming, subjective, error‐prone. The purpose this study develop...