A5022848231- Plant-Microbe Interactions and Immunity
- Plant Pathogenic Bacteria Studies
- Plant Virus Research Studies
- Plant Parasitism and Resistance
- Legume Nitrogen Fixing Symbiosis
- Plant Reproductive Biology
- Experimental Behavioral Economics Studies
- Plant tissue culture and regeneration
- Lung Cancer Treatments and Mutations
- Plant Pathogens and Fungal Diseases
- Corruption and Economic Development
- Gastric Cancer Management and Outcomes
- Plant Gene Expression Analysis
- Biochemical and Molecular Research
- Plant biochemistry and biosynthesis
- Cancer therapeutics and mechanisms
- Plant Molecular Biology Research
- Color Science and Applications
- Advanced Breast Cancer Therapies
- Protein Degradation and Inhibitors
- CRISPR and Genetic Engineering
- Photosynthetic Processes and Mechanisms
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Healthcare Policy and Management
Zhejiang University
2023
Zhejiang Gongshang University
2023
University of British Columbia
2015-2021
John Innes Centre
2020-2021
Norwich Research Park
2020-2021
SihuanPharm (China)
2017
Tianjin Normal University
2015
Salicylic acid (SA) is a plant defense hormone required for immunity. Arabidopsis NPR1 and NPR3/NPR4 were previously shown to bind SA all three proteins proposed as receptors. functions transcriptional co-activator, whereas suggested function E3 ligases that promote degradation. Here we report co-repressors inhibits their activities the expression of downstream immune regulators. npr4-4D, gain-of-function npr4 allele renders NPR4 unable SA, constitutively represses SA-induced responses. In...
Spontaneous degradation in hormone synthesis The phytohormone salicylic acid (SA) helps plants respond to biological and physical stresses. Rekhter et al. identified the biosynthetic pathway that produces SA response pathogens. A precursor, isochorismic acid, is formed chloroplast then exported cytosol. There, enzymatically produced isochorismate-9-glutamate spontaneously decomposes release plus a by-product. results clarify key steps mechanisms involved synthesizing this important regulator...
Abstract Recognition of pathogens by host plants leads to rapid transcriptional reprogramming and activation defence responses. The expression many regulators is induced in this process, but the mechanisms how they are controlled transcriptionally largely unknown. Here we use chromatin immunoprecipitation sequencing show that transcription factors SARD1 CBP60g bind promoter regions a large number genes encoding key plant immunity. Among them positive systemic immunity signalling components...
The plant defense hormone salicylic acid (SA) is perceived by two classes of receptors, NPR1 and NPR3/NPR4. They function in parallel pathways to regulate SA-induced gene expression. To better understand the roles SA receptors defense, we systematically analyzed their contributions different aspects Arabidopsis (Arabidopsis thaliana) immunity using SA-insensitive npr1-1 npr4-4D double mutant. We found that perception NPR4 required for activation N-hydroxypipecolic biosynthesis, which...
Systemic acquired resistance (SAR) is an immune response induced in the distal parts of plants following defense activation local tissue. Pipecolic acid (Pip) accumulation orchestrates SAR and responses. Here, we report identification characterization SAR-DEFICIENT4 (SARD4), which encodes a critical enzyme for Pip biosynthesis Arabidopsis thaliana Loss function SARD4 leads to reduced levels precursor, Δ1-piperideine-2-carboxylic (P2C). In Escherichia coli, expression aminotransferase ALD1...
604 Background: KRAS G12C mutation is an oncogenic driver and a validated therapeutic target in solid tumors. Glecirasib, highly selective, covalent oral inhibitor, has demonstrated promising clinical activity NSCLC CRC; however, the efficacy safety of glecirasib are unknown PDAC other tumors with mutation. Methods: Two phase 1/2 trials (NCT05009329 China; NCT05002270 US, Europe Israel) evaluating patients (pts) tumor harboring mutations. As both have similar inclusion exclusion criteria, we...
SARD1 and CBP60g are two master regulators in plant immunity. They required for the constitutive defense responses Arabidopsis snc2-1D mutant, which carries a gain-of-function mutation receptor-like protein. Here we report that WRKY54 WRKY70 activation of expression snc2-1D. In addition, induction by bacterial pathogen Pseudomonas syringae pv. maculicola is significantly reduced sid2 wrky54 wrky70 triple mutants compared to single mutants, suggesting positively regulate SID2-independent...
Abstract The phytohormone salicylic acid (SA) is a central regulator of plant immunity. Despite such functional importance, our knowledge its biosynthesis incomplete. Previous work showed that SA synthesized from chorismic in plastids. bulk pathogen-induced derives isochorismate generated by the catalytic activity ISOCHORISMATE SYNTHASE1 (ICS1). How and which cellular compartment converted to unknown. Here we show pathway downstream requires only two additional proteins: plastidial exporter...
Introduction This study investigated the impact of competition on supplier-induced demand in medical markets theoretically and experimentally. Methods We employed framework credence goods to describe information asymmetry between physicians patients, derives predictions physicians' behaviors monopolistic competitive markets. Then we conducted behavioral experiments empirically test hypotheses. Results The theoretical analysis revealed that an honest equilibrium would not exist a market,...
2565 Background: KBP-5209 is a novel potent and irreversible inhibitor of tyrosine kinases the human epidermal growth factor receptor (EGFR) family that preclinically has demonstrated antitumor activities in esophageal gastric cancers NSCLC. Methods: This first-in-human study (NCT02442414) was conducted to determine tolerability, safety, pharmacokinetics activity administered QD or BID patients (pts) with advanced solid tumors. Dose escalation (DE) initially based on modified accelerated...