Roger Hardie

ORCID: 0000-0001-5531-3264
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About
Contact & Profiles
Research Areas
  • Neurobiology and Insect Physiology Research
  • Retinal Development and Disorders
  • Circadian rhythm and melatonin
  • Photoreceptor and optogenetics research
  • Ion Channels and Receptors
  • Insect and Arachnid Ecology and Behavior
  • Physiological and biochemical adaptations
  • Plant and Biological Electrophysiology Studies
  • bioluminescence and chemiluminescence research
  • Receptor Mechanisms and Signaling
  • Ion channel regulation and function
  • Insect Utilization and Effects
  • Antioxidant Activity and Oxidative Stress
  • Biochemical Analysis and Sensing Techniques
  • Insect and Pesticide Research
  • Spaceflight effects on biology
  • Insect Resistance and Genetics
  • Genetics, Aging, and Longevity in Model Organisms
  • Light effects on plants
  • Plant and animal studies
  • Cellular transport and secretion
  • Olfactory and Sensory Function Studies
  • Visual perception and processing mechanisms
  • Neural dynamics and brain function
  • Invertebrate Immune Response Mechanisms

University of Cambridge
2013-2022

Shanghai Center for Brain Science and Brain-Inspired Technology
2018-2019

Fudan University
2018-2019

Bridge University
1988-2017

Wolfson Foundation
2008

Droplet Measurement Technologies (United States)
2008

UCLouvain
2008

University of Wales
2008

Cardiff University
2008

University of Oulu
2006

10.1007/bf00615241 article EN Journal of Comparative Physiology A 1987-01-01

This paper presents a novel maximum posteriori estimator for enhancing the spatial resolution of an image using co-registered high spatial-resolution imagery from auxiliary sensor. Here, we focus on use high-resolution panchomatic data to enhance hyperspectral imagery. However, estimation framework developed allows any number spectral bands in primary and image. The proposed technique is suitable applications where some correlation, either localized or global, exists between being enhanced....

10.1109/tip.2004.829779 article EN IEEE Transactions on Image Processing 2004-08-16

10.1016/0166-2236(86)90136-0 article EN Trends in Neurosciences 1986-01-01

Phototransduction in Drosophila microvillar photoreceptor cells is mediated by a G protein-activated phospholipase C (PLC). PLC hydrolyzes the minor membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP(2)), leading an unknown mechanism to activation of prototypical transient receptor potential (TRP) and TRP-like (TRPL) channels. We found that light exposure evoked rapid PLC-mediated contractions modulated activity mechanosensitive channels introduced into cells. Furthermore, responses...

10.1126/science.1222376 article EN Science 2012-10-11

Cell and organelle membranes consist of a complex mixture phospholipids (PLs) that determine their size, shape, function. Phosphatidylcholine (PC) is the most abundant phospholipid in eukaryotic membranes, yet how cells sense regulate its levels vivo remains unclear. Here we show PCYT1A, rate-limiting enzyme PC synthesis, intranuclear re-locates to nuclear membrane response need for PL synthesis yeast, fly, mammalian cells. By aligning imaging with lipidomic analysis data-driven modeling,...

10.1016/j.devcel.2018.04.012 article EN cc-by Developmental Cell 2018-05-01

Color and motion information are thought to be channeled through separate neural pathways, but it remains unclear whether how these pathways interact improve perception. In insects, such as Drosophila, has long been believed that is fed exclusively by one spectral class of photoreceptor, so-called R1 R6 cells; whereas R7 R8 photoreceptors, which exist in multiple classes, subserve color vision. Here, we report also contribute the pathway. By using electrophysiological, optical, behavioral...

10.1126/science.1215317 article EN Science 2012-05-17
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