A5101761968- Effects and risks of endocrine disrupting chemicals
- Carcinogens and Genotoxicity Assessment
- Microplastics and Plastic Pollution
- Cancer-related molecular mechanisms research
- Nanoparticles: synthesis and applications
- Circular RNAs in diseases
- Pesticide Exposure and Toxicity
- MicroRNA in disease regulation
- Hepatitis B Virus Studies
- Toxic Organic Pollutants Impact
- Sperm and Testicular Function
- Mental Health Treatment and Access
- Graphene and Nanomaterials Applications
- Hepatitis C virus research
- Influenza Virus Research Studies
- Air Quality and Health Impacts
- COVID-19 Clinical Research Studies
- Biopolymer Synthesis and Applications
- Animal testing and alternatives
- Cholesterol and Lipid Metabolism
- Suicide and Self-Harm Studies
- Neonatal Respiratory Health Research
- IL-33, ST2, and ILC Pathways
- SARS-CoV-2 and COVID-19 Research
- Child and Adolescent Psychosocial and Emotional Development
Jiangsu Provincial Center for Disease Control and Prevention
2016-2025
Nanjing Medical University
2004-2024
Second Military Medical University
2020-2024
Changhai Hospital
2020-2024
Nanjing Health and Health Commission
2023
Anhui University of Technology
2023
Huaiyin Institute of Technology
2022
Shanghai Mental Health Center
2007-2019
Capital Medical University
2011-2018
Beijing YouAn Hospital
2018
Rationale: Aberrant bronchial epithelium-fibroblast communication is essential for the airway remodeling that contributes to chronic obstructive pulmonary disease (COPD).Exosomes have emerged as novel mediators of intercellular communication, but their role in cigarette smoke (CS)-induced COPD unknown.Here, we investigated exosomal miR-21 dysfunctional cross-talk caused by CS.Methods: Normal or CS extract (CSE)-treated human epithelial (HBE) cells were co-cultured with fibroblasts (MRC-5...
Chinese university students often suffer from acute stress, which can affect their mental health. We measured and evaluated perceived stress in this population using the Simplified version of 10-item Perceived Stress Scale (SCPSS-10). The SCPSS-10, Patient Health Questionnaire (PHQ), Generalized Anxiety Disorder 7-item scale (GAD-7) were conducted 1096 students. Two weeks later, 129 participants re-tested SCPSS-10. Exploratory factor analysis yielded two factors with Eigen values 4.76 1.48,...
Microplastics (MPs) pollution has become a global concern due to its close relation the environment and human health. Recently, more studies have pointed out existence of MPs in air, but potential inhalation toxicity is unclear. Polystyrene (PS-MPs) one representative MPs. Besides, non-coding RNA plays crucial roles regulating gene expression. Therefore, this study aims provide new insights into molecular exploration PS-MPs inhalation. In study, Sprague Dawley(SD)rats were treated with 100...
Transgenerational nanoplastic toxicity could be detected in Caenorhabditis elegans after exposure at the parental generation (P0-G); however, underlying mechanisms remain largely unclear. We aimed to examine role of germline nuclear hormone receptors (NHRs) controlling transgenerational polystyrene nanoparticles (PS-NPs) based on gene expression screening and functional analysis. Among NHR genes, daf-12, nhr-14, nhr-47 expressions were increased nhr-12 was decreased by PS-NPs (1 10 μg/L)....
To determine sperm nuclear DNA integrity and to investigate the relation between fenvalerate (FE) exposure spermatozoa damage.Sperm fragmentation was detected by a modified alkaline single cell gel electrophoresis (Comet) assay terminal deoxynucleotidyl transferase mediated dUTP nick end labelling (TUNEL) assay. The olive tail moment (OTM) percentage were measured Comet assay, positive TUNEL for damage evaluation.The of external internal control groups both significantly greater than that FE...
Mutations and transient conformational movements of the receptor binding domain (RBD) that make neutralizing epitopes momentarily unavailable present immune escape routes for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To mitigate viral escape, we developed a cocktail antibodies (NAbs) targeting located on different domains spike (S) protein. Screening library monoclonal generated from peripheral blood mononuclear cells COVID-19 convalescent patients yielded potent NAbs,...
In nematode Caenorhabditis elegans, exposure to polystyrene nanoparticles (PS-NPs) at predicted environmental concentrations can cause induction of transgenerational toxicity. However, the underlying mechanisms for toxicity formation PS-NP in offspring remain largely unknown. this study, based on high-throughput sequencing, Ephrin ligand EFN-3 was identified as a target KSR-1/2 (two kinase suppressors Ras) germline during control At parental generation (P0-G), 0.1-10 μg/L caused increase...
Microplastics (MPs) are plastic particles < 5 mm in diameter, of which polystyrene microplastics (PS-MPs) representative type. The extracellular matrix (ECM) degradation macrophages is associated with the development emphysema. Additionally, circular RNAs (circRNAs) have a regulatory role epigenetic mechanisms related to lung disease. However, ECM and circRNAs MPs-induced emphysema still unclear. In our study, Sprague-Dawley (SD) rats were treated 0, 0.5, 1.0 2.0 mg/m
Carbaryl, one of the most important insecticides, is widely produced and used. To explore carbaryl-induced genotoxic effects spermatozoa, particularly DNA damage chromosome aberrations (CA), we first examined conventional semen parameters, progression motion parameters spermatozoa among 16 carbaryl-exposed workers 30 internal external control individuals. Sperm represented as positive percentage fragmentation was detected by a modified terminal deoxy-nucleotidyl transferase-mediated...
The recent adoption of China's new national mental health law provides a good opportunity to obtain baseline information about community literacy in the country.Assess knowledge and attitudes disorders among residents Shanghai.A total 1953 aged 15 or above selected from all 19 districts Shanghai completed two self-report questionnaires - Mental Health Knowledge Questionnaire (MHKQ) Case Assessment (CAQ). MHKQ scores range 0 20 (higher indicate better literacy). CAQ presents respondents with...