A5017344489- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Arsenic contamination and mitigation
- Traditional Chinese Medicine Analysis
- MicroRNA in disease regulation
- Liver Disease and Transplantation
- Cardiac, Anesthesia and Surgical Outcomes
- Mesenchymal stem cell research
- Inflammatory Bowel Disease
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer Mechanisms and Therapy
- Enhanced Recovery After Surgery
- Heavy Metal Exposure and Toxicity
- Hepatitis B Virus Studies
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Folate and B Vitamins Research
- Liver Disease Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Cancer-related molecular mechanisms research
- Kruppel-like factors research
- Liver Diseases and Immunity
- Peptidase Inhibition and Analysis
Suzhou Research Institute
2023-2024
Guangdong Provincial People's Hospital
2024
Guangdong Academy of Medical Sciences
2024
Southern Medical University
2024
Second Military Medical University
2010-2023
Nanjing Medical University
2018-2023
Eastern Hepatobiliary Surgery Hospital
2010-2023
Huazhong University of Science and Technology
1997-2022
Union Hospital
2022
The Ohio State University Wexner Medical Center
2019-2020
Although surgery offers the best chance of a potential cure for patients with localized, resectable intrahepatic cholangiocarcinoma (ICC), prognosis remains dismal largely because high incidence recurrence.To predict very early recurrence (VER) (ie, within 6 months after surgery) following resection ICC in pre- and postoperative setting.Patients who underwent curative-intent between May 1990 July 2016 were identified from an international multi-institutional database. The study was conducted...
Adenosine 5'-triphosphate citrate lyase (ACLY) is a cytosolic enzyme that converts into acetyl-coenzyme A for fatty acid and cholesterol biosynthesis. ACLY up-regulated or activated in many cancers, targeting by inhibitors holds promise as potential cancer therapy. However, the role of immunity regulation remains poorly understood. Here, we show inhibition up-regulates PD-L1 immune checkpoint expression cells induces T cell dysfunction to drive immunosuppression compromise its antitumor...
Purpose To assess the accuracy of magnetic resonance (MR) imaging-based differential diagnosis hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) in a cohort patients with focal liver lesions cirrhosis. Materials Methods This study was institutional review board approved, requirement for informed consent waived. Between January 2009 December 2014, cirrhotic patients, including 71 ICC 612 HCC, underwent unenhanced T1- T2-weighted MR imaging, gadolinium-based contrast...
Background:Whether Crohn's disease [CD] is correlated with brain structural changes unclear. This study examined in grey matter [GM] structures CD patients and their correlation psychological distress.
The rapid increase in carbon black poses threats to human health. We evaluated the effect of CB (Printex 90) on osteogenesis bone-marrow-derived mesenchymal stem cells (MSCs). Mitochondria play an important role MSCs and are potential targets nanomaterials, so we studied mitochondria Printex 90-induced effects osteogenesis. Low doses 90 (3 ng/mL 30 ng/mL) that did not cause deleterious MSCs' viability significantly inhibited MSCs. caused down-regulation osteoblastic markers, reduced activity...
Abstract Arsenicosis induced by chronic exposure to arsenic is recognized as one of the main damaging effects on public health. Exposure can cause hepatic fibrosis, but molecular mechanisms which this occurs are complex and elusive. It not known if miRNAs involved in arsenic‐induced liver fibrosis. We found that livers mice exposed arsenite, there were elevated levels microRNA‐21 (miR‐21), phosphorylated mammalian target rapamycin (p‐mTOR), arginase 1 (Arg1); low phosphatase tensin homolog...
Abstract Background and Objective Financial hardship occurring as a result of cancer treatment has been termed financial toxicity is an established side effect the treatment. We investigated risk among patients undergoing surgery for gastrointestinal cancers. Methods All uninsured privately insured who underwent were identified from National Inpatient Sample. Publicly available government data used estimate income, food expenditure, average maximum out‐of‐pocket expenditure. Risk was defined...
Cadmium is a common environmental pollutant that causes bone damage. However, the effects of cadmium on osteogenic differentiation marrow mesenchymal stem cells (BMMSCs) and its mechanism action in this process are unclear. Here, we determined chloride (CdCl2) BMMSCs potential involved process. As present investigation, CdCl2, concentration-dependent manner, affected viability their cytoskeletons. Exposure to 0.1 or 0.2 µM CdCl2 inhibited BMMSCs, which was reflected down-regulation...
Few data are available regarding the management and outcomes among patients with sarcomatoid hepatocellular carcinoma (HCC) due to its rarity.Patients diagnosed HCC from 2004 through 2015 were identified in National Cancer Data Base. Overall survival (OS) was calculated versus conventional using a 1:3 propensity score matching based on sex, age, American Joint Committee (AJCC) stage of disease.The final analytic cohort included 104 312 HCC. Patients more often had larger median tumor size...
Arsenic is an environmental toxicant and human carcinogen.
microRNAs (miRNAs) participate in the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). However, few reports have discussed effect miRNAs on magnesium chloride (MgCl 2 )-induced promotion BMSCs, a process involved healing tissue. As determined present investigation, MgCl decreased miR-16 levels; increased levels fibroblast growth factor (FGF2), p-p38, and p-ERK; promoted BMSCs. Enhancement by an mimic blocked these -induced changes. Moreover, luciferase reporter...
Background: Obesity, a chronic metabolic disorder, is related to cardiovascular diseases, diabetes, cancer, and reproductive disorders. The relationship between obesity male infertility now well recognized, but the mechanisms involved are unclear. We aimed observe effect of on spermatogenesis investigate role histone ubiquitination acetylation modifications in obesity-induced Methods: Thirty C57BL/6J mice were randomly divided into two groups. control group was fed with general maintenance...
Abstract Elevated mean corpuscular volume (MCV) is common in persons with hemochromatosis associated HFE C282Y homozygosity. We evaluated data from the subset of non‐Hispanic white participants Hemochromatosis and Iron Overload Screening Study to determine if elevated MCV homozygotes related this genotype or serum iron measures. Regression analysis was used model Hb transferrin saturation (TfSat), ferritin (SF), hemoglobin concentration, red blood cell count, age, genotype, Field Center,...