A5017801656- Immunotherapy and Immune Responses
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- Lung Cancer Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Cancer Genomics and Diagnostics
- T-cell and B-cell Immunology
- Hepatitis B Virus Studies
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Biochemical Analysis and Sensing Techniques
- Cytokine Signaling Pathways and Interactions
- CAR-T cell therapy research
- vaccines and immunoinformatics approaches
- MicroRNA in disease regulation
- Monoclonal and Polyclonal Antibodies Research
- Olfactory and Sensory Function Studies
- Colorectal Cancer Treatments and Studies
- Immune Response and Inflammation
- Paraquat toxicity studies and treatments
Hunan Agricultural University
2025
Northeastern University
2023-2025
Renji Hospital
2010-2024
Shanghai Chest Hospital
1996-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Shanghai Jiao Tong University
2014-2024
Research Institute of Petroleum Exploration and Development
2012-2024
Affiliated Hospital of Nantong University
2009-2024
Nantong University
2009-2024
Royal Prince Alfred Hospital
2024
Age-associated B cells (ABCs) accumulate during infection, aging, and autoimmunity, contributing to lupus pathogenesis. In this study, we screened for transcription factors driving ABC formation found that zinc finger E-box binding homeobox 2 (ZEB2) is required human mouse differentiation in vitro. ABCs are reduced ZEB2 haploinsufficient individuals mice lacking Zeb2 cells. with toll-like receptor 7 (TLR7)–driven lupus, essential autoimmune pathology. binds +20-kb myocyte enhancer factor 2b...
Immunity against phosphopeptide antigens lacking in leukemia patients can be restored with stem cell transplantation.
The activation and recruitment of CD4(+) T cells are critical for the development efficient antitumor immunity may allow optimization current cancer immunotherapy strategies. Searching more optimal selective targets cells, we have investigated phosphopeptides, a new category tumor-derived epitopes linked to proteins with vital cellular functions. Although MHC I-restricted phosphopeptides been identified, it was previously unknown whether human II molecules present specific cell recognition....
Mutation of p53 is the most common genetic change in human cancer, causing complex effects including not only loss wild-type function but also gain novel oncogenic functions (GOF). It increasingly likely that p53-hotspot mutations may confer different types and magnitudes GOF, evidences are mainly supported by cellular transgenic animal models. Here we combine large-scale cancer genomic data to characterize prognostic significance cancers. Unexpectedly, on Arg248 Arg282 positions displayed...
Objective Increasing evidence indicates that the cyclic GMP ‐ AMP synthase/stimulator of interferon genes ( cGAS / STING ) signaling pathway has a critical pathogenic role in systemic lupus erythematosus SLE ). Expression levels (IFN)–inducible gene IFIT 3 are elevated patients. However, it is still not clear how contributes to pathogenesis . This study was undertaken investigate activation human monocytes, and determine expression could contribute overactive patients with SLE. Methods...
A hallmark of systemic lupus erythematosus is high titers circulating autoantibodies. Recently, a novel CD11c+ B-cell subset has been identified that critical for the development autoimmunity. However, role B cells in unclear. Chronic graft-versus-host disease (cGVHD) lupus-like syndrome with autoantibody production. The purpose this study was to explore pathogenesis cGVHD mice.cGVHD induced by an intraperitoneal injection 5 × 107 Bm12 splenocytes into B6 mice. Flow cytometry used analyze...
Type I interferon (IFN) is a critical pathogenic factor during the progression of lupus nephritis (LN). Although microRNAs (miRNAs) have been shown to control IFN response in immune cells LN, role miRNAs resident renal remains unclear. We undertook this study investigate microRNA-130b (miR-130b) pathway as well its therapeutic effect LN.Kidney tissues from patients and (NZB × NZW)F1 lupus-prone mice were collected for detecting miR-130b levels. Primary mesangial (RMCs) used determine...
Objective: Lupus nephritis (LN) is one of the most serious complications systemic lupus erythematosus (SLE). Type I interferon (IFN-I) associated with pathogenesis LN. Long non-coding RNAs (lncRNAs) have been implicated in SLE, however, roles lncRNAs LN are still poorly understood. Here, we identified and investigated function LN-associated lncRNA RP11-2B6.2 regulating IFN-I signaling pathway. Methods: RNA sequencing was used to analyze expression kidney biopsies from patients controls....
Kokumi taste substances exemplified by γ-glutamyl peptides and Maillard Peptides modulate salt umami tastes. However, the underlying mechanism for their action has not been delineated. Here, we investigated effects of a kokumi active inactive peptide fraction (500–10,000 Da) isolated from mature (FIIm) immature (FIIim) Ganjang, typical Korean soy sauce, on responses in humans rodents. Only FIIm (0.1–1.0%) produced biphasic effect rat chorda tympani (CT) nerve to lingual stimulation with 100...
This study aimed to compare the differences in characteristics and prognoses between Asian white patients receiving immunotherapy for nonsmall cell lung cancer (NSCLC). We studied 390 who received atezolizumab as part of POPLAR or OAK trial, analyzed baseline characteristics, outcomes genetic mutations blood samples patients. Overall survival (OS) was longer compared (median OS: 18.7 vs . 11.1 months; p = 0.005). Race identified an independent prognostic factor OS (Asian white: hazard ratio...
T-614 is a novel oral antirheumatic agent for the treatment of rheumatoid arthritis. Whether it has immunomodulatory or disease-modifying properties and its mechanism action are largely undetermined. Rats with collagen-induced arthritis (CIA) were treated (5 20 mg/kg) daily. Animals receiving methotrexate (1 mg/kg every 3 days) nonsteroidal anti-inflammatory nimesulide (10 per day) used as controls. A combination therapy group was both T-614(10 days). Hind paw swelling evaluated radiographic...
Abstract Background Remnant cholesterol (RC) and nonhigh-density lipoprotein (nonHDL-C) are key risk factors for atherosclerotic cardiovascular disease (ASCVD), with apolipoprotein B (apoB) lipoprotein(a) [Lp(a)] also contributing to its residual risk. However, real-world population-based evidence regarding the impact of current clinical LDL-C-centric lipid-lowering therapy (LLT) on achieving RC nonHDL-C goals, as well modifying CVD is limited. Methods This prospective observational study...
The present study investigated the effect of replacement chemical fertilizers by organic on agronomic traits tobacco at maturity as well conventional quality post-roasted leaves. To better understand relationship between metabolites and roasted under nitrogen treatments, post-roasting leaves were analyzed an untargeted metabolomics analytical approach to identify key applicable predicting quality. Methods: Yunyun Tobacco 87 was adopted test material in a field plot experiment with five...
Although dendritic cell (DC) vaccines offer promise as cancer immunotherapy, further improvements are needed to amplify their clinical therapeutic efficacy. The pattern recognition scavenger receptor SRA/CD204 attenuates the ability of DCs activate CD8(+) T-cell responses. Therefore, we examined impact on antitumor responses generated by DC and also evaluated feasibility enhancing vaccine potency blockade. from SRA/CD204-deficient mice were more immunogenic in generating B16 melanoma,...
We have previously reported that adiponectin (AD), an adipokine is secreted by adipocytes, correlates well with progressive bone erosion in rheumatoid arthritis (RA). The exact mechanism of AD promoting joint destruction remains unclear. Osteopontin (OPN) required for osteoclast recruitment. hypothesized exacerbates inducing OPN expression synovial tissue. This study aimed to evaluate a novel role RA. serum levels and were determined 38 patients RA, 40 osteoarthritis (OA), 20 healthy...
Objective To investigate the prognostic significance of 23 matrix metalloproteinase ( MMP) genes in patients diagnosed with ovarian carcinoma. Methods The MMP carcinoma was investigated using Kaplan–Meier plotter (KM plotter), which uses gene expression data and overall survival information cancer that were downloaded from Gene Expression Omnibus, Cancer Biomedical Informatics Grid Genome Atlas datasets. correlation between mRNA levels individual MMPs (MMP2, MMP9, MMP10, MMP12, MMP13 MMP25)...
A significant association between high blood-based tumor mutational burden (bTMB) and improved progression-free survival (PFS) was observed in advanced non-small cell lung cancer (NSCLC) receiving atezolizumab. However, this result unrepeatable a recent prospective study. We hypothesized that there might be non-linear bTMB survival. This study used the clinical genetic data from POPLAR (n = 105, training set) OAK 324, validation trials. The assessed using restricted cubic spline (RCS)....
Disruption of B cell homeostasis and subsequent dominance effector subsets are critical for the development systemic lupus erythematosus (SLE). Revealing key intrinsic regulators involved in homeostatic control cells has important therapeutic value SLE. This study was undertaken to determine regulatory role transcription factor Pbx1 pathogenesis.We constructed mice with cell-specific deletion Pbx1. T cell-dependent cell-independent humoral responses were induced by intraperitoneal injection...