A5068567744- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Neuroimaging Techniques and Applications
- Neurogenesis and neuroplasticity mechanisms
- Alzheimer's disease research and treatments
- Barrier Structure and Function Studies
- Ginkgo biloba and Cashew Applications
- Axon Guidance and Neuronal Signaling
- Cerebrovascular and Carotid Artery Diseases
- Botulinum Toxin and Related Neurological Disorders
- Acute Ischemic Stroke Management
- Cerebral Palsy and Movement Disorders
- Flavonoids in Medical Research
- Neonatal and fetal brain pathology
- Bioactive Compounds in Plants
- Moyamoya disease diagnosis and treatment
- Advanced MRI Techniques and Applications
- Phytochemical Studies and Bioactivities
Beijing Shijitan Hospital
2022-2025
Capital Medical University
2018-2025
2,3,5,6-Tetramethylpyrazine (TMP) as an active ingredient extracted from a traditional Chinese herbal medicine Ligusticum chuanxiong Hort . has been proved to penetrate blood-brain barrier (BBB) and show neuroprotective effects on cerebral ischemia. However, whether TMP could regulate astrocytic reactivity facilitate neurovascular restoration in the subacute ischemic stroke needs be urgently verified. In this research, permanent occlusion of middle artery (MCAO) model was conducted (10, 20,...
Enriched environment (EE) with a complex combination of sensorimotor, cognitive and social stimulations has been shown to enhance brain plasticity improve recovery functions in animal models stroke. The present study extended these findings by assessing whether the three-phase EE intervention paradigm would neurovascular remodeling following ischemic Male Sprague-Dawley rats were subjected permanent middle cerebral artery occlusion (MCAO). A was designed terms different periods ischemia...
Identifying the alterations of cerebral gray and white matter is an important prerequisite for developing potential pharmacological therapy stroke. This study aimed to assess changes after permanent middle artery occlusion (pMCAO) in rats using magnetic resonance imaging (MRI), correlate them with behavior performance. Rats were subjected pMCAO or sham surgery reared 30 days. Motor cognitive function examined by gait Morris water maze (MWM) tests, respectively. Multimodal MRI was conducted...
Xiaoshuan enteric-coated capsule (XSEC) is a Chinese medicinal compound widely used for treatment of ischemic cerebrovascular diseases. Enriched environment (EE) an effective rehabilitative protocol designed to enhance sensorimotor, cognitive and social stimulation. This study aimed apply magnetic resonance imaging (MRI) noninvasively assess whether EE could augment the therapeutic benefits XSEC on post-ischemic neurovascular remodeling. Male Sprague-Dawley rats were subjected permanent...
Xiaoshuan enteric-coated capsule (XSEC) is a compound Chinese medicine widely used for the treatment of ischemic stroke. Enriched environment (EE) rehabilitative intervention designed to facilitate physical, cognitive, and social activity after brain injury. This study aimed assess whether XSEC EE combination could provide synergistic efficacy in axonal remodeling compared that with single stroke using magnetic resonance imaging (MRI) followed by histological analysis. Rats were subjected...
Ischemic stroke elicits white matter injury typically signed by axonal disintegration and demyelination; thus, the development of reorganization is needed. 2,3,5,6-Tetramethylpyrazine (TMP) widely used to treat ischemic stroke. This study was aimed investigate whether TMP could protect promote repair after cerebral ischemia. Male Sprague-Dawley rats were subjected permanent middle artery occlusion (MCAO) treated with (10, 20, 40 mg/kg) intraperitoneally for 14 days. The motor function...
Abstract Chronic cerebral hypoperfusion (CCH) is identified as a critical risk factor of dementia in patients with cerebrovascular disease. Xiaoshuan enteric-coated capsule (XSECC) compound Chinese medicine approved by State Food and Drug Administration for promoting brain remodeling plasticity after stroke. The present study aimed to explore the potential XSECC improve cognitive function CCH further investigate underlying mechanisms. was induced bilateral common carotid artery occlusion...
Xiaoshuan enteric-coated capsule (XSECC) is a drug approved by the Chinese State Food and Drug Administration for treatment of stroke. This study was to investigate effects XSECC on white gray matter injury in rat model ischemic stroke diffusion tensor imaging (DTI) histopathological analyses. The ischemia induced middle cerebral artery occlusion (MCAO). blood flow measured arterial spin labeling improved with 3rd, 7th, 14th 30th days after MCAO. Spatiotemporal changes MCAO rats were...
Trillium tschonoskii Maxim. (TTM), is a perennial herb from Liliaceae, that has been widely used as traditional Chinese medicine treating cephalgia and traumatic hemorrhage. The present work was designed to investigate whether the total saponins (TSTT) would promote brain remodeling improve gait impairment in chronic phase of ischemic stroke. A focal model male Sprague-Dawley (SD) rats established by permanent middle cerebral artery occlusion (MCAO). Six hours later, were intragastrically...