Zhengyuan Shi

ORCID: 0000-0003-4394-6237
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About
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Research Areas
  • Glioma Diagnosis and Treatment
  • Traditional Chinese Medicine Analysis
  • Advanced Neuroimaging Techniques and Applications
  • Cancer, Lipids, and Metabolism
  • Neurological Disease Mechanisms and Treatments
  • Alzheimer's disease research and treatments
  • Advanced biosensing and bioanalysis techniques
  • Seed Germination and Physiology
  • Acute Lymphoblastic Leukemia research
  • Transgenic Plants and Applications
  • Advanced Biosensing Techniques and Applications
  • Rice Cultivation and Yield Improvement
  • Pharmacological Effects of Natural Compounds
  • Hepatitis B Virus Studies
  • Genetic Mapping and Diversity in Plants and Animals
  • Plant tissue culture and regeneration
  • Hepatitis C virus research
  • Ginseng Biological Effects and Applications
  • Drug-Induced Hepatotoxicity and Protection
  • Phytochemistry and Biological Activities
  • Hematopoietic Stem Cell Transplantation
  • Essential Oils and Antimicrobial Activity
  • GABA and Rice Research
  • Biosensors and Analytical Detection
  • Cancer, Hypoxia, and Metabolism

Beijing Shijitan Hospital
2018-2024

Capital Medical University
2018-2024

China International Science and Technology Cooperation
2020

China National Rice Research Institute
2014

Institute of Crop Sciences
2011

Chinese Academy of Agricultural Sciences
2011

Shenyang Pharmaceutical University
2008-2011

Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL Plasma Lipidomics Profiling Identify Signatures of Pediatric Medulloblastoma 18 Pages Posted: 9 Jan 2025 See all articles by Zhengyuan ShiZhengyuan Shiaffiliation not provided SSRNChunjing Yangaffiliation SSRNLi Baoaffiliation SSRNWanshui Wuaffiliation SSRNDechun Jiangaffiliation SSRN Abstract is similar other common tumors the posterior cranial...

10.2139/ssrn.5081485 preprint EN 2025-01-01

Methotrexate (MTX) pharmacokinetics has substantial inter-individual variability and toxicity. In children with medulloblastoma treated high-dose methotrexate (HD-MTX), the pharmacokinetic properties of have not been established. A total 660 serum samples from 105 pediatric patients were included in a population (PPK) analysis by using nonlinear mixed-effects modeling method. The basic one-compartment model was established NONMEM software first-order conditional estimation (FOCE) method,...

10.1002/bdd.2221 article EN Biopharmaceutics & Drug Disposition 2020-02-04

Xueshuantong Lyophilized Powder (XST), consisting of a series saponins extracted from Panax notoginseng, is widely applied to treat acute cerebral infarction, stroke and coronary heart disease in China. However, most adverse drug reactions (ADR) clinic are caused by quality problems XST. In this study, 6 batches certainly abnormal, 4 possibly abnormal XST 8 normal were obtained the clinical practice. Their fluctuations identified ultra-performance liquid chromatography coupled with an...

10.3389/fphar.2018.00633 article EN cc-by Frontiers in Pharmacology 2018-06-15

ABSTRACT Imidol hydrochloride is a novel drug for the treatment of hepatitis B virus infection. A simple, special and sensitive solid‐phase extraction liquid chromatography–tandem mass spectrometry method determination imidol in human plasma urine was developed first time applied to pharmacokinetic study. The chromatographic separation achieved on C 18 column (50 × 2.1 mm, 3.5 µm) using gradient elution with acetonitrile water both containing 0.1% acetic acid at flow rate 0.25 mL/min....

10.1002/bmc.1687 article EN Biomedical Chromatography 2011-08-16

Rapid and simple monitoring of vancomycin (VAN) concentration in blood is a vital strategy for maximizing therapeutic efficacy, minimizing toxicity developing personalized treatment plan. In this work, multicolor immunosensor proposed to enable rapid VAN serum, without using any expensive bulky instrument. The platform system that works based on the principle product cetyltrimethylammonium bromide-blue oxide 3,3',5,5'-tetramethylbenzidine interaction (CTAB/TMB+) TMB+ increases simultaneously...

10.1039/d3ay00873h article EN Analytical Methods 2023-01-01

The cover image is based on the Original Article* Population Pharmacokinetics of High-Dose Methotrexate in Chinese Pediatric Patients with Medulloblastoma by Dan Yan** et al., https://doi.org/10.1002/bdd.2221.***

10.1002/bdd.2225 article EN Biopharmaceutics & Drug Disposition 2020-03-01
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