A5101600632- Apelin-related biomedical research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Nuclear Receptors and Signaling
- Advanced biosensing and bioanalysis techniques
- Building materials and conservation
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Gut microbiota and health
- Mitochondrial Function and Pathology
- Probiotics and Fermented Foods
- Immune cells in cancer
- MicroRNA in disease regulation
- Lipid metabolism and disorders
- Adipose Tissue and Metabolism
- Cultural Heritage Materials Analysis
- Conservation Techniques and Studies
- Circular RNAs in diseases
- Pregnancy and preeclampsia studies
- Cancer-related molecular mechanisms research
- Heme Oxygenase-1 and Carbon Monoxide
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Biosensors and Analytical Detection
- Concrete and Cement Materials Research
Nanjing Normal University
2025
First Affiliated Hospital of University of South China
2016-2025
University of South China
2015-2025
Huazhong University of Science and Technology
2024-2025
Tongji Hospital
2024-2025
State Administration of Cultural Heritage
2022-2024
Northwest University
2009-2024
Wannan Medical College
2024
Nanjing Drum Tower Hospital
2022-2024
Southwest Medical University
2022-2024
Abstract Aberrant proliferation of vascular smooth muscle cells (VSMC) is a critical contributor to the pathogenesis atherosclerosis (AS). Our previous studies have demonstrated that apelin‐13/APJ confers proliferative response in VSMC, however, its underlying mechanism remains elusive. In this study, we aimed investigate role mitophagy apelin‐13‐induced VSMC and atherosclerotic lesions apolipoprotein E knockout (ApoE‐/‐) mice. Apelin‐13 enhances human aortic regulator proliferating cell...
Overexpression of structural maintenance chromosomes 4 (SMC4) has been reported to be involved in tumor cell growth, migration and invasion, correlated with poor prognosis cancer patient. However, its clinical significance biological role glioma remain unknown. Herein, we found that SMC4 expression at both mRNA protein level was markedly increased cells tissues it prognosis. overexpression promoted the proliferation rate invasive capability vitro vivo, whereas downregulation reduced it....
Apelin is highly expressed in rat left ventricular hypertrophy Sprague Dawley models, and it plays a crucial role the cardiovascular system. The aim this study was to clarify whether apelin-13 promotes H9c2 cardiomyocytes investigate its underlying mechanism. cardiomyocyte observed by measuring diameter, volume, protein content of cells. activation autophagy evaluated observing morphology autophagosomes transmission electron microscopy, subcellular localization LC3 light detecting...
A localized catalytic hairpin assembly-based DNA nanomachine (LCHA nanomachine) was developed for the rapid, efficient and reliable fluorescence resonance energy transformation (FRET) imaging of miRNA-21 in living cells.
Background: Heart failure (HF) is a serious public health concern. Baicalin one of the major active ingredients traditional Chinese herbal medicine, Huang Qin, which used to treat patients with chest pain or cardiac discomfort. However, underlying mechanism(s) cardioprotective effect baicalin are still not fully understood. Methods: Isoprenaline injection transverse aortic constriction-induced animal models and isoprenaline angiotensin 2 administration-induced cell heart were established....
Abstract Aim Pyroptosis is a type of programmed cell death characterized by pro‐inflammatory activity and an important factor in pre‐eclampsia (PE). Trimethylamine N‐oxide (TMAO) gut microbial metabolite closely associated with pyroptosis PE. This study aims to investigate the role TMAO trophoblast explore possible mechanisms. Methods Western blot qRT‐polymerase chain reaction (PCR) were used detect expression levels ten‐eleven translocation 2 (TET2), cytochrome b (CYTB), pyroptosis‐related...
Summary Adipocytokines apelin peptide, the ligand of APJ (putative receptor related to angiotensin AT 1 ), plays key roles in pathogenesis and deterioration cancer. In lung cancer, elevating microvessel densities has been reported. Our previous research characterized that apelin‐13 promoted adenocarcinoma cell proliferation. However, effect on metastasis underlying mechanisms remain unclear. This study shows induced human migration via receptor. Apelin‐13 phosphorylated PAK cofilin increase...