A5101898693- Spine and Intervertebral Disc Pathology
- Cardiac Imaging and Diagnostics
- Scoliosis diagnosis and treatment
- Coronary Interventions and Diagnostics
- Cardiac Ischemia and Reperfusion
- Spinal Fractures and Fixation Techniques
- Musculoskeletal pain and rehabilitation
- Cardiac Arrest and Resuscitation
- Acute Myocardial Infarction Research
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Anesthesia and Neurotoxicity Research
- Acupuncture Treatment Research Studies
- Inhalation and Respiratory Drug Delivery
- Advanced Drug Delivery Systems
- Apelin-related biomedical research
- Cervical and Thoracic Myelopathy
- Renin-Angiotensin System Studies
- Total Knee Arthroplasty Outcomes
- Layered Double Hydroxides Synthesis and Applications
- Mechanical Circulatory Support Devices
- Advanced biosensing and bioanalysis techniques
- TGF-β signaling in diseases
- Advanced X-ray and CT Imaging
Nanjing University
2024-2025
Guangxi University
2024
Guangxi University of Chinese Medicine
2024
Nanjing University of Chinese Medicine
2023-2024
University of Copenhagen
2019-2024
XinHua Hospital
2024
Southwest Jiaotong University
2024
Second Hospital of Anhui Medical University
2023
Anhui Medical University
2023
Zoucheng People's Hospital
2023
Abstract Aberrant proliferation of vascular smooth muscle cells (VSMC) is a critical contributor to the pathogenesis atherosclerosis (AS). Our previous studies have demonstrated that apelin‐13/APJ confers proliferative response in VSMC, however, its underlying mechanism remains elusive. In this study, we aimed investigate role mitophagy apelin‐13‐induced VSMC and atherosclerotic lesions apolipoprotein E knockout (ApoE‐/‐) mice. Apelin‐13 enhances human aortic regulator proliferating cell...
CD26 has been reported as a marker for colorectal cancer stem cells endowed with tumor-initiating properties and capable of (CRC) metastasis. In this study, we investigated the functional effect on CRC angiogenesis metastasis, potential underlying mechanism. The effects overexpression or repression were determined by wound healing experiment, cell migration invasion assays in vitro mouse models. Differentially expressed genes regulated identified genome-wide mRNA expression array validated...
Inhaled antibiotic treatment of cystic fibrosis-related bacterial biofilm infections is challenging because the pathological environment lungs. Here, we present an "environment-adaptive" nanoparticle composed a solid poly lactic-co-glycolic acid (PLGA) core and mucus-inert, enzymatically cleavable shell d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) for site-specific delivery antibiotics to biofilms via aerosol administration. The hybrid nanoparticles with ultrasmall size were...
Pulmonary artery hypertension (PAH), a progressive, lethal condition that results in pathologic changes the pulmonary arterial tree, eventually leads to right heart failure. Work identifying mutations Type II Bone morphogenetic protein (Bmp) receptor, BmpRII, families with PAH has implicated Bmp-signaling pathogenesis of PAH. However, effectors downstream BmpRII remain unclear since signals via Smad-dependent and independent mechanisms. We investigated Smad8 function, divergent receptor...
The combination/fusion of quantitative coronary angiography (QCA) and intravascular ultrasound (IVUS)/optical coherence tomography (OCT) depends to a great extend on the co-registration X-ray (XA) IVUS/OCT. In this work new robust three-dimensional (3D) segmentation registration approach is presented validated. starts with standard QCA vessel interest in two angiographic views (either biplane or monoplane views). Next, reconstructed 3D registered corresponding IVUS/OCT pullback series by...
Rheumatoid arthritis (RA) is an immune-mediated disease with the characteristics of progressive joint destruction, deformity, and disability. Epigenetic changes have been implicated in development some autoimmune disorders, resulting alteration gene transcription. Here, we investigated how Jumonji C family histone demethylases (JMJD3) regulated proliferation activation fibroblast-like synoviocytes (FLSs), which are involved RA destruction pathologic process. The JMJD3 expression markers...
Ratiometric afterglow luminescent (AGL) probes are attractive for in vivo imaging due to their high sensitivity and signal self-calibration function. However, there currently few ratiometric AGL available enzymatic activity living organisms. Here, we present an energy diversion (ED) strategy that enables the design of enzyme-activated probe (RAG-RGD) imaging. The ED process provides RAG-RGD with a radiative transition 'always on' 520-nm (AGL
Early detection and precise tumor localization are critical for improving treatment outcomes enabling more targeted minimally invasive therapies as biotechnology evolves. However, endogenous biomarkers from early lesions face significant challenges, such short circulation times blood dilution, which hinder diagnostic efforts. In this study, we present a multimodal nanosensor specifically engineered to target cancer by responding CD44 tumor-associated enzymes within the microenvironment....
Background The clinical application of recombinant tissue plasminogen activator (rt-PA) is significantly constrained by hemorrhagic transformation (HT), a common and severe complication following thrombolysis for ischemic stroke. Notably, the mitochondrial injury-mediated NLRP3 inflammasome plays crucial role in HT after delayed rt-PA acute Although acupuncture has demonstrated antioxidant anti-inflammatory effects cerebral infarction, its impact on thrombolysis, especially concerning...
Low-Dose Chest CT: Optimizing Radiation Protection for PatientsXiaohua Zhu1, Jianqun Yu2 and Zheng Huang3Audio Available | Share
A facile and feasible approach was developed to prepare layered double hydroxide (LDH) composite membranes by using amino acids as intercalation molecules.
Accurate on-line assessments of vessel dimensions are utmost importance for selecting the appropriate stent size in coronary interventions. Recently a new three-dimensional quantitative angiography (3D QCA) analytical software package was developed to accurately assess planning and guidance such This study aimed validate 3D QCA assessing arterial segment length by comparing with intravascular ultrasound (IVUS). In addition, difference two measurements from IVUS curved segments studied.A...
Salivary duct carcinoma (SDC) is a rare high-grade aggressive neoplasm that manifests close histologic features with invasive ductal of the breast (IDC). In contrast to SDC, extensive molecular studies have been performed on IDC and led identification certain biological markers. To investigate underlying biologic characteristics we analyses using microsatellite markers chromosomal arms 6q, 16q, 17p, 17q, DNA flow cytometry immunohistochemical staining for androgen receptor (AR) p53...
The cyclin-dependent kinase inhibitors p27Kip1 and p21WAF1/Cip1 play important roles in cell-cycle regulation. Although alterations of these genes have been linked to tumorigenesis several human carcinomas, their involvement head neck squamous is rarely investigated. To determine the role evolution carcinoma we evaluated protein expression by immunohistochemistry non-dysplastic epithelium, premalignant lesions oral carcinomas. p53 gene Ki-67 expressions were correlated with traditional...
Study Design: Retrospective cohort study. Objective: The purpose of this study is to compare the radiographic and clinical outcomes expandable interbody spacers static spacers. Methods: This a retrospective, institutional review board–exempt chart 62 consecutive patients diagnosed with degenerative disc disease who underwent minimally invasive spine surgery lateral lumbar fusion (MIS LLIF) using or There were 27 treated spacers, 35 Radiographic functional collected. Statistical results...
Previous studies have shown that heat shock protein 90 (HSP90)-mediated mitochondrial import of connexin 43 (Cx43) is critical in preconditioning cardioprotection. The present study was designed to test whether postconditioning has the same effect as promoting Cx43 translocation mitochondria and HSP90 modulates this effect.Cellular models hypoxic (HPC) from rat heart-derived H9c2 cells neonatal cardiomyocytes were employed. effects HPC on apoptosis examined by flow cytometry Hoechst 33342...
A vertically channeled layered double hydroxides membrane was prepared for molecular sieving.
BACKGROUND: Myocardial inflammation mediated by toll-like receptor 4 (TLR4) plays an active role in myocardial ischemia/reperfusion (I/R) injury. Studies show that heat shock protein 90 (HSP90) is involved ischemic postconditioning (IPostC) cardioprotection. This study investigates the roles of TLR4 and HSP90 IPostC. METHODS: Rats were subjected to 30 min ischemia, then 2 h reperfusion. IPostC was applied three cycles s reperfusion, reocclusion at reperfusion onset. Sixty rats randomly...