The approved intravenous adeno-associated virus (AAV) therapies are limited by the widespread prevalence of pre-existing anti-AAV antibodies in general population, which known to restrict patients' ability receive gene therapy and limit transfection efficacy vivo. To address this challenge, we have developed a novel recombinant human immunoglobulin G degrading enzyme KJ103, characterized low immunogenicity clinical value for elimination transfer. Herein, conducted two randomized, blinded,...

Abstract Objective To establish the population pharmacokinetics (PPK) of magnesium sulfate (MgSO 4 )in women with preeclampsia (PE), and to determine key covariates having an effect in Chinese PE. Methods Pregnant PE prescribed MgSO4 were enrolled this prospective study from April 2021 2023. On initial day administration, patients administered a loading dose 5 g conjunction 10 as maintenance dose. second day, only was maternal blood samples taken at 0, 4, 5, 12 h after day’s The software...

Abstract Background The aim of the present study was to evaluate impact intratumoral metabolic heterogeneity and quantitative 18 F‐FDG PET/CT imaging parameters in predicting patient outcomes thymic epithelial tumors (TETs). Methods This retrospective included 100 patients diagnosed with TETs who underwent pretreatment PET/CT. maximum mean standardized uptake values (SUVmax SUVmean), tumor volume (MTV), total lesion glycolysis (TLG) on were measured. Heterogeneity index‐1 (HI‐1; standard...

Introduction: Alterations in certain microRNAs (miRNAs) and their target genes have reported polycystic ovary syndrome (PCOS) other disease of the female reproductive system, so may be potential biomarkers. We hypothesised alterations prevalence four miRNAs single nucleotide polymorphism (SNP) variants miR-126 rs4636297, miR-146a rs2910164, miR-196a2 rs11614913, miR-499 rs3746444 women with PCOS comparison to healthy controls. Methods: SNPs were determined 385 patients controls by standard...

Abstract Background Magnesium sulfate (MgSO 4 ) is the standard drug for eclampsia prophylaxis and treatment. In China, effective therapeutic serum magnesium level 1.8–3.0 mmol/L. There little information on how to achieve maintain concentrations. This study aimed investigate risk factors sub-therapeutic concentrations of MgSO in patients with severe preeclampsia. Methods Patients preeclampsia who received intravenous infusion were retrospectively reviewed. The maternal demographic...

In the follow-up of patients with differentiated thyroid cancer (DTC), several had elevated serum levels antithyroglobulin antibody (TgAb), undetectable thyroglobulin (Tg), and negative radioiodine whole body scan (131I-WBS). We describe use neck ultrasonography (US) fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) imaging in these to investigate this clinically challenging problem propose treating.A total 49 DTC TgAb (>115IU/mL), Tg 131I-WBS...

<title>Abstract</title> The approved recombinant adeno-associated virus (AAV) intravenous drugs are limited by the high prevalence of pre-existing anti-AAV antibodies in general population, which known to restrict patients’ ability receive gene therapy and limit transfection efficacy vivo. Based on that, we developed a novel low immunogenicity human immunoglobulin G degrading enzyme (KJ103), has clinical value removing anti- AAV vivo transfer. Herein, performed two randomized, blinded,...

Objective: To investigate the value of integrated pancreatic and biliary stents for prevention post-Endoscopic Retrograde Cholangiopancreatography (ERCP) pancreatitis. Methods: The clinical data patients whom had post-ERCP pancreatitis from December 2013 to October 2015 were retrospectively analyzed. effect complication compared between straight group group. Results: A total 214 Among them, 139 received a with average operation time 62.1±9.8 min 75 67.2±12.7 min. was statistically...

Objective To investigate 18F-fluorodeoxyglucose(18F-FDG)positron emission tomography(PET)/computed tomography(CT)multimodal imaging features and clinical manifestations of renal lymphoma. Methods A retrospective study was performed on 99 cases patients with lymphoma who were admitted in the department Nuclear Medicine, first Affiliated Hospital Zhengzhou University underwent 18F-FDG PET/CT from January 2011 to December 2018.There 69 males 30 females, an average age of(45±23)years old,...

Abstract BACKGROUND : Gastric cancer (GC) is one of the most common malignant cancers, with high morbidity and mortality rates worldwide. The present study was to explore whether miR-200b a tumor suppressor in GC unveil potential mechanisms. METHODS: Levels c-Myc, Cyclin D1, MMP-3 MMP-9 expression were detected respectively by qRT-PCR Western blot assay. BrdU proliferation assay, Cell cycle analysis, Wound-healing Transwell assays used role inhibitor, mimics or ZEB1-RNAi TGF-β1-treated...

Abstract Background: Magnesium sulfate (MgSO 4 ) is the standard drug for eclampsia prophylaxis and treatment. In China, effective therapeutic serum magnesium level 1.8–3.0 mmol/L. There little information on how to achieve maintain concentrations. This study aimed investigate risk factors sub-therapeutic concentrations of MgSO in patients with severe preeclampsia. Methods: Patients preeclampsia who received intravenous infusion were retrospectively reviewed. The maternal demographic...

Abstract Background: Magnesium sulfate (MgSO 4 ) is the standard drug for eclampsia prophylaxis and treatment. In China, effective therapeutic serum magnesium level 1.8–3.0 mmol/L. There little information on how to achieve maintain concentrations. This study aimed investigate risk factors sub-therapeutic concentrations of MgSO in patients with severe preeclampsia. Methods: Patients preeclampsia who received intravenous infusion were retrospectively reviewed. The maternal demographic...

Abstract BACKGROUND : Gastric cancer (GC) is one of the most common malignant cancers, with high morbidity and mortality rates worldwide. The present study was to explore whether miR-200b a tumor suppressor in GC unveil potential mechanisms. METHODS: Levels c-Myc, Cyclin D1, MMP-3 MMP-9 expression were detected respectively by qRT-PCR Western blot assay. BrdU proliferation assay, Cell cycle analysis, Wound-healing Transwell assays used role inhibitor, mimics or ZEB1-RNAi TGF-β1-treated...

Abstract Background: Magnesium sulfate (MgSO 4 ) is the standard drug for eclampsia prophylaxis and treatment. In China, effective therapeutic serum magnesium level 1.8–3.0 mmol/L. There little information on how to achieve maintain concentrations. This study aimed investigate risk factors sub-therapeutic concentrations of MgSO in patients with severe preeclampsia. Methods: Patients preeclampsia who received intravenous infusion were retrospectively reviewed. The maternal demographic...

Abstract BACKGROUND : Gastric cancer (GC) is one of the most common malignant cancers, with high morbidity and mortality rates worldwide. The present study was to explore whether miR-200b a tumor suppressor in GC unveil potential mechanisms. METHODS: Levels c-Myc, Cyclin D1, MMP-3 MMP-9 expression were detected respectively by qRT-PCR Western blot assay. BrdU proliferation assay, Cell cycle analysis, Wound-healing Transwell assays used role inhibitor, mimics or ZEB1-RNAi TGF-β1-treated...

Abstract Background: Magnesium sulfate (MgSO4) is the ideal drug for eclampsia prophylaxis and treatment. In China, effective therapeutic serum magnesium level 1.8–3.0 mmol/L. Although there have been individual reports on use of MgSO4 in pregnant women with severe preeclampsia, little information how to achieve maintain concentrations China. This study aimed investigate risk factors sub-therapeutic patients preeclampsia.Methods: Patients preeclampsia who received intravenous (IV) infusion...

Abstract BACKGROUND : Gastric cancer (GC) is one of the most common malignant cancers, with high morbidity and mortality rates worldwide. The present study was to explore whether miR-200b a tumor suppressor in GC unveil potential mechanisms. METHODS: Levels c-Myc, Cyclin D1, MMP-3 MMP-9 expression were detected respectively by qRT-PCR Western blot assay. BrdU proliferation assay, Cell cycle analysis, Wound-healing Transwell assays used role inhibitor, mimics or ZEB1-RNAi TGF-β1-treated...

Abstract BACKGROUND : Gastric cancer (GC) is one of the most common malignant cancers, with high morbidity and mortality rates worldwide. The present study was to explore whether miR-200b a tumor suppressor in GC unveil potential mechanisms. METHODS: Levels c-Myc, Cyclin D1, MMP-3 MMP-9 expression were detected respectively by qRT-PCR Western blot assay. BrdU proliferation assay, Cell cycle analysis, Wound-healing Transwell assays used role inhibitor, mimics or ZEB1-RNAi TGF-β1-treated...